SEBP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEBP2_HUMAN
• UniProt AC: Q96T21
• Protein Name: Selenocysteine insertion sequence-binding protein 2
• Gene Name: SECISBP2
• Organism: Homo sapiens (Human).
• Sequence Length: 854
• Subcellular Localization: Isoform 1: Nucleus .; Isoform 2: Mitochondrion .
• Protein Description: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB..
• Protein Sequence: MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSVGAVPVLSKECASGERGRRMSQMKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERKQRLQENAVSPAFTSDDTQDGESGGDDQFPEQAELSGPEGMDELISTPSVEDKSEEPPGTELQRDTEASHLAPNHTTFPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLKKLKCVIISPNCEKIQSKGGLDDTLHTIIDYACEQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTVAARQAYKTMLENVQQELVGEPRPQAPPSLPTQGPSCPAEDGPPALKEKEEPHYIEIWKKHLEAYSGCTLELEESLEASTSQMMNLNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASEGPREP ------CCCCCCCCC	19.11	-
15	Acetylation	EPESEGIKLSADVKP CCCCCCCCCCCCCCC	47.44	12433889
21	Ubiquitination	IKLSADVKPFVPRFA CCCCCCCCCCCCCCC	33.03	-
26	Methylation	DVKPFVPRFAGLNVA CCCCCCCCCCCCEEE	28.84	115493599
58	Ubiquitination	YPFVQEPPVTEQKIY CCCCCCCCCCCCEEE	44.93	-
60	Phosphorylation	FVQEPPVTEQKIYTE CCCCCCCCCCEEECC	38.17	29759185
65	Phosphorylation	PVTEQKIYTEDMAFG CCCCCEEECCCCCCC	15.88	29759185
66	Phosphorylation	VTEQKIYTEDMAFGA CCCCEEECCCCCCCC	29.05	29759185
90	Ubiquitination	SEITLHPYAYSPYTL CCEEECCCCCCCCCC	13.87	-
105	Ubiquitination	DSTQNVYSVPGSQYL CCCCCEEECCHHHHH	19.97	-
126	Ubiquitination	YRGFQTVKHRNENTC HCCCCCCCCCCCCCC	39.99	-
140	Ubiquitination	CPLPQEMKALFKKKT CCCCHHHHHHHCCCC	40.98	-
158	Ubiquitination	KKTYDQQKFDSERAD CCCCCHHHHCHHHCC	45.57	-
173	Ubiquitination	GTISSEIKSARGSHH CCCHHHHHHCCCCCC	33.73	-
174	Phosphorylation	TISSEIKSARGSHHL CCHHHHHHCCCCCCE	28.94	20044836
176	Methylation	SSEIKSARGSHHLSI HHHHHHCCCCCCEEE	54.99	115493607
184	Phosphorylation	GSHHLSIYAENSLKS CCCCEEEEEECCCCC	12.41	25159151
199	Ubiquitination	DGYHKRTDRKSRIIA CCCCCCCCCCCCEEE	61.10	-
238	Ubiquitination	NNMSEIQKQPKWGPV CCHHHHHHCCCCCCC	74.38	-
247	Phosphorylation	PKWGPVHSVSTDISL CCCCCCCCCCCCHHH	20.28	23186163
249	Phosphorylation	WGPVHSVSTDISLLR CCCCCCCCCCHHHHH	24.31	25954137
250	Phosphorylation	GPVHSVSTDISLLRE CCCCCCCCCHHHHHH	34.89	25954137
253	Phosphorylation	HSVSTDISLLREVVK CCCCCCHHHHHHHHC	24.94	23186163
260	Ubiquitination	SLLREVVKPAAVLSK HHHHHHHCHHHEECC	33.83	-
267	Ubiquitination	KPAAVLSKGEIVVKN CHHHEECCCEEEECC	57.30	-
273	Ubiquitination	SKGEIVVKNNPNESV CCCEEEECCCCCCCC	39.86	-
285	Ubiquitination	ESVTANAATNSPSCT CCCEEECCCCCCCCC	13.71	-
286	Phosphorylation	SVTANAATNSPSCTR CCEEECCCCCCCCCC	33.54	25159151
288	Phosphorylation	TANAATNSPSCTREL EEECCCCCCCCCCEE	17.52	25159151
290	Phosphorylation	NAATNSPSCTRELSW ECCCCCCCCCCEECC	28.13	21712546
292	Phosphorylation	ATNSPSCTRELSWTP CCCCCCCCCEECCCC	31.36	29978859
296	Phosphorylation	PSCTRELSWTPMGYV CCCCCEECCCCCCCC	24.93	28857561
307	Phosphorylation	MGYVVRQTLSTELSA CCCCHHHHHCHHHCC	16.47	-
326	Ubiquitination	VTSMINLKTIASSAD CCCCEEHHHHHCCCC	33.14	-
335	Ubiquitination	IASSADPKNVSIPSS HHCCCCCCCCCCCCH	71.21	-
338	Phosphorylation	SADPKNVSIPSSEAL CCCCCCCCCCCHHHH	37.87	29978859
341	Phosphorylation	PKNVSIPSSEALSSD CCCCCCCCHHHHCCC	38.86	29978859
341	O-linked_Glycosylation	PKNVSIPSSEALSSD CCCCCCCCHHHHCCC	38.86	30379171
342	Phosphorylation	KNVSIPSSEALSSDP CCCCCCCHHHHCCCC	22.87	28985074
346	Phosphorylation	IPSSEALSSDPSYNK CCCHHHHCCCCCCCC	39.48	29978859
347	Phosphorylation	PSSEALSSDPSYNKE CCHHHHCCCCCCCCC	55.16	29978859
350	Phosphorylation	EALSSDPSYNKEKHI HHHCCCCCCCCCCCC	46.45	29978859
351	Phosphorylation	ALSSDPSYNKEKHII HHCCCCCCCCCCCCC	35.32	29978859
353	Ubiquitination	SSDPSYNKEKHIIHP CCCCCCCCCCCCCCH	60.96	-
355	Ubiquitination	DPSYNKEKHIIHPTQ CCCCCCCCCCCCHHH	41.53	-
361	Phosphorylation	EKHIIHPTQKSKASQ CCCCCCHHHHCCCCC	34.17	25690035
364	Phosphorylation	IIHPTQKSKASQGSD CCCHHHHCCCCCCCH	24.52	25247763
367	Phosphorylation	PTQKSKASQGSDLEQ HHHHCCCCCCCHHHH	38.52	30108239
370	Phosphorylation	KSKASQGSDLEQNEA HCCCCCCCHHHHHHH	31.24	25159151
378	Phosphorylation	DLEQNEASRKNKKKK HHHHHHHHHHHHHHH	37.29	21406692
384	Ubiquitination	ASRKNKKKKEKSTSK HHHHHHHHHCCCCCC	68.71	-
388	Phosphorylation	NKKKKEKSTSKYEVL HHHHHCCCCCCCEEE	38.72	26657352
392	Phosphorylation	KEKSTSKYEVLTVQE HCCCCCCCEEEECCC	15.84	28796482
396	Phosphorylation	TSKYEVLTVQEPPRI CCCCEEEECCCCCCC	25.89	28796482
424	Phosphorylation	ERRDRIETPKFQSKQ HHHHCCCCCCCCCCC	29.43	29978859
429	Phosphorylation	IETPKFQSKQQPQDN CCCCCCCCCCCCCCC	35.25	29978859
499	Phosphorylation	GERGRRMSQMKTPHN CCCHHCHHHCCCCCC	25.88	24719451
533	Acetylation	AKKPTSLKKIILKER CCCCCCHHHHHHHHH	41.51	24431589
609	Phosphorylation	GTELQRDTEASHLAP CCCCCCCCHHHHCCC	35.32	24732914
612	Phosphorylation	LQRDTEASHLAPNHT CCCCCHHHHCCCCCC	16.89	24732914
619	Phosphorylation	SHLAPNHTTFPKIHS HHCCCCCCCCCCHHH	36.45	24732914
620	Phosphorylation	HLAPNHTTFPKIHSR HCCCCCCCCCCHHHH	30.32	24732914
632	Ubiquitination	HSRRFRDYCSQMLSK HHHHHHHHHHHHHHH	6.97	-
646	Phosphorylation	KEVDACVTDLLKELV HHHHHHHHHHHHHHH	22.33	28258704
650	Ubiquitination	ACVTDLLKELVRFQD HHHHHHHHHHHHHHH	57.19	-
660	Phosphorylation	VRFQDRMYQKDPVKA HHHHHHHHCCCCCCH	17.19	18083107
662	Ubiquitination	FQDRMYQKDPVKAKT HHHHHHCCCCCCHHH	46.65	-
803	Glutathionylation	LPTQGPSCPAEDGPP CCCCCCCCCCCCCCC	4.10	22833525
815	Ubiquitination	GPPALKEKEEPHYIE CCCCCCCCCCCCHHH	66.83	-
820	Phosphorylation	KEKEEPHYIEIWKKH CCCCCCCHHHHHHHH	15.80	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEBP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEBP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEBP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 609698: Abnormal thyroid hormone metabolism (ATHYHM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330