| UniProt ID | SNPC2_HUMAN | |
|---|---|---|
| UniProt AC | Q13487 | |
| Protein Name | snRNA-activating protein complex subunit 2 | |
| Gene Name | SNAPC2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 334 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.. | |
| Protein Sequence | MKPPPRRRAAPARYLGEVTGPATWSAREKRQLVRLLQARQGQPEPDATELARELRGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEVWTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQEDPAPEIPSSAPAAPSSAPRTPDPAPEKPSESSAGPSTEEDFAVDFEKIYKYLSSVSRSGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPIPAGGSLGPAAEGDGAGSKAPEETPPATEKAEHSELKSPWQAAGICPLNPFLVPLELLGRAATPAR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | RRAAPARYLGEVTGP CCCCCCHHCCCCCCC | 22.59 | 26074081 | |
| 19 | Phosphorylation | ARYLGEVTGPATWSA CHHCCCCCCCCCCCH | 32.90 | 26074081 | |
| 23 | Phosphorylation | GEVTGPATWSAREKR CCCCCCCCCCHHHHH | 24.08 | 26074081 | |
| 25 | Phosphorylation | VTGPATWSAREKRQL CCCCCCCCHHHHHHH | 17.06 | 26074081 | |
| 70 | Ubiquitination | RVFLQQLKGRVAREA HHHHHHHCHHHHHHH | 40.09 | - | |
| 80 | Ubiquitination | VAREAIQKVHPGGLQ HHHHHHHHHCCCCCC | 36.08 | 29967540 | |
| 181 | Phosphorylation | APSSAPRTPDPAPEK CCCCCCCCCCCCCCC | 30.86 | 23663014 | |
| 190 | Phosphorylation | DPAPEKPSESSAGPS CCCCCCCCCCCCCCC | 62.27 | 27732954 | |
| 192 | Phosphorylation | APEKPSESSAGPSTE CCCCCCCCCCCCCCH | 29.80 | 27732954 | |
| 193 | Phosphorylation | PEKPSESSAGPSTEE CCCCCCCCCCCCCHH | 32.94 | 27732954 | |
| 212 | Phosphorylation | DFEKIYKYLSSVSRS CHHHHHHHHHHHCCC | 8.54 | - | |
| 214 | Phosphorylation | EKIYKYLSSVSRSGR HHHHHHHHHHCCCCC | 26.13 | - | |
| 292 | Phosphorylation | GSKAPEETPPATEKA CCCCCCCCCCCCHHH | 32.67 | 21815630 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNPC2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNPC2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNPC2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBP_HUMAN | TBP | physical | 8633057 | |
| SNPC4_HUMAN | SNAPC4 | physical | 9418884 | |
| TBP_HUMAN | TBP | physical | 8524284 | |
| SNPC4_HUMAN | SNAPC4 | physical | 8524284 | |
| SNPC1_HUMAN | SNAPC1 | physical | 8524284 | |
| SNPC3_HUMAN | SNAPC3 | physical | 8524284 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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