SNPC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNPC3_HUMAN
• UniProt AC: Q92966
• Protein Name: snRNA-activating protein complex subunit 3
• Gene Name: SNAPC3
• Organism: Homo sapiens (Human).
• Sequence Length: 411
• Subcellular Localization: Nucleus.
• Protein Description: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box..
• Protein Sequence: MAEGSRGGPTCSGVGGRQDPVSGSGGCNFPEYELPELNTRAFHVGAFGELWRGRLRGAGDLSLREPPASALPGSQAADSDREDAAVARDLDCSLEAAAELRAVCGLDKLKCLEDGEDPEVIPENTDLVTLGVRKRFLEHREETITIDRACRQETFVYEMESHAIGKKPENSADMIEEGELILSVNILYPVIFHKHKEHKPYQTMLVLGSQKLTQLRDSIRCVSDLQIGGEFSNTPDQAPEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTARMEDFTFNDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDRTLYPLLIKKHWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGEFLAYPYVDPGTFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MAEGSRGGPTCSG --CCCCCCCCCCCCC	66.01	115917337
62	Phosphorylation	LRGAGDLSLREPPAS CCCCCCCCCCCCCCC	30.07	24719451
74	Phosphorylation	PASALPGSQAADSDR CCCCCCCCCCCCCCH	18.08	17525332
93	Phosphorylation	VARDLDCSLEAAAEL HHHHHHCHHHHHHHH	28.98	30576142
108	Ubiquitination	RAVCGLDKLKCLEDG HHHHCCCHHCCCCCC	55.69	22817900
110	Ubiquitination	VCGLDKLKCLEDGED HHCCCHHCCCCCCCC	42.38	21963094
161	Phosphorylation	TFVYEMESHAIGKKP CEEEEEHHHHCCCCC	19.53	25849741
244	Ubiquitination	QAPEHISKDLYKSAF CCCHHHCHHHHHHHH	51.67	22505724
287	Ubiquitination	SHDRGYGKFQTARME HCCCCCCCCCCCEEC	26.30	22817900
287	Acetylation	SHDRGYGKFQTARME HCCCCCCCCCCCEEC	26.30	26051181
338	Phosphorylation	HDDCLDRTLYPLLIK CHHHCHHCHHHHHHH	30.25	-
345	Ubiquitination	TLYPLLIKKHWLWTR CHHHHHHHHHHHHCC	38.26	21890473
345	Acetylation	TLYPLLIKKHWLWTR CHHHHHHHHHHHHCC	38.26	26051181
346	Ubiquitination	LYPLLIKKHWLWTRK HHHHHHHHHHHHCCC	32.78	-
395	Ubiquitination	HYDSEGNKLGEFLAY EECCCCCCCCEECCC	69.59	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNPC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNPC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNPC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB_HUMAN	RB1	physical	11094070
SNPC1_HUMAN	SNAPC1	physical	9003788
DHB14_HUMAN	HSD17B14	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.
PubMed: 17525332