FOXF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXF2_HUMAN
• UniProt AC: Q12947
• Protein Name: Forkhead box protein F2
• Gene Name: FOXF2
• Organism: Homo sapiens (Human).
• Sequence Length: 444
• Subcellular Localization: Nucleus.
• Protein Description: Probable transcription activator for a number of lung-specific genes..
• Protein Sequence: MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	APSAACKSAGGGGAG CCCHHCHHCCCCCCC	31.84	23403867
85	Phosphorylation	GGGAGAGSGGAKKAS CCCCCCCCCCCCCCC	33.25	23403867
104	Phosphorylation	RPEKPPYSYIALIVM CCCCCCCCEEEHHHH	18.81	-
153	Phosphorylation	NSVRHNLSLNECFIK HHHHHCCCHHHEEEE	34.17	20873877
160	Sumoylation	SLNECFIKLPKGLGR CHHHEEEECCCCCCC	38.18	-
160	Acetylation	SLNECFIKLPKGLGR CHHHEEEECCCCCCC	38.18	18525493
160	Sumoylation	SLNECFIKLPKGLGR CHHHEEEECCCCCCC	38.18	-
160	Ubiquitination	SLNECFIKLPKGLGR CHHHEEEECCCCCCC	38.18	29967540
163	Acetylation	ECFIKLPKGLGRPGK HEEEECCCCCCCCCC	76.76	18525501
188	Phosphorylation	EFMFEEGSFRRRPRG HHCCCCCCCCCCCCH	20.89	24719451
204	Acetylation	RRKCQALKPMYHRVV HHHHHHHHHHHHHHH	30.65	22424773
350	Sumoylation	PGASPYLKQPPALTP CCCCCCCCCCCCCCC	55.72	-
390	Phosphorylation	QNAREDLSVGLPRYQ HHHHHHHHCCCCCCC	26.85	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOXF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_HUMAN	TBP	physical	9722567
TF2B_HUMAN	GTF2B	physical	9722567

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.