NR5A2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR5A2_MOUSE
• UniProt AC: P45448
• Protein Name: Nuclear receptor subfamily 5 group A member 2
• Gene Name: Nr5a2
• Organism: Mus musculus (Mouse).
• Sequence Length: 560
• Subcellular Localization: Nucleus .
• Protein Description: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development..
• Protein Sequence: MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRLVMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASKGLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSPESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAALLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSASLDTGD ------CCCCCCCCC	26.94	23984901
4	Phosphorylation	----MSASLDTGDFQ ----CCCCCCCCCHH	21.33	23984901
7	Phosphorylation	-MSASLDTGDFQEFL -CCCCCCCCCHHHHH	43.90	23984901
23	Phosphorylation	HGLTAIASAPGSETR CCCHHHHCCCCCCCC	28.96	29472430
27	Phosphorylation	AIASAPGSETRHSPK HHHCCCCCCCCCCCH	34.43	29472430
29	Phosphorylation	ASAPGSETRHSPKRE HCCCCCCCCCCCHHH	35.07	29472430
32	Phosphorylation	PGSETRHSPKREEQL CCCCCCCCCHHHHHH	28.91	29472430
173	Sumoylation	KCIDVGMKLEAVRAD HHCHHCCCHHHHHHH	36.93	-
229	Phosphorylation	QAMPSDLTSAIQNIH HHCCCHHHHHHHHHH	22.54	28576409
257	Phosphorylation	PPTDYDRSPFVTSPI CCCCCCCCCCCCCCC	21.57	29119230
261	Phosphorylation	YDRSPFVTSPISMTM CCCCCCCCCCCCCCC	29.21	29119230
262	Phosphorylation	DRSPFVTSPISMTMP CCCCCCCCCCCCCCC	18.22	29119230
265	Phosphorylation	PFVTSPISMTMPPHS CCCCCCCCCCCCCCH	16.16	29119230
267	Phosphorylation	VTSPISMTMPPHSSL CCCCCCCCCCCCHHC	21.53	29119230
272	Phosphorylation	SMTMPPHSSLHGYQP CCCCCCCHHCCCCCC	40.13	29119230
273	Phosphorylation	MTMPPHSSLHGYQPY CCCCCCHHCCCCCCC	22.73	29119230
277	Phosphorylation	PHSSLHGYQPYGHFP CCHHCCCCCCCCCCC	8.79	29119230
280	Phosphorylation	SLHGYQPYGHFPSRA HCCCCCCCCCCCCCH	14.01	29119230
285	Phosphorylation	QPYGHFPSRAIKSEY CCCCCCCCCHHCCCC	33.14	29119230
289	Sumoylation	HFPSRAIKSEYPDPY CCCCCHHCCCCCCCC	35.93	-
308	Phosphorylation	ESMMGYSYMDGYQTN HHHCCCCCCCCCCCC	7.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NR5A2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
289	K	Sumoylation	Sumoylated by SUMO1 at Lys-289 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR5A2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR1H4_MOUSE	Nr1h4	physical	20483916

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.