RU1C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RU1C_MOUSE
• UniProt AC: Q62241
• Protein Name: U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}
• Gene Name: Snrpc {ECO:0000255|HAMAP-Rule:MF_03153}
• Organism: Mus musculus (Mouse).
• Sequence Length: 159
• Subcellular Localization: Nucleus .
• Protein Description: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region..
• Protein Sequence: MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPAPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MPKFYCDYCD -----CCCCCCCCCC	47.90	22826441
5	Phosphorylation	---MPKFYCDYCDTY ---CCCCCCCCCCCE	7.19	25777480
8	Phosphorylation	MPKFYCDYCDTYLTH CCCCCCCCCCCEECC	6.67	25159016
11	Phosphorylation	FYCDYCDTYLTHDSP CCCCCCCCEECCCCC	19.50	25159016
12	Phosphorylation	YCDYCDTYLTHDSPS CCCCCCCEECCCCCH	9.06	25159016
14	Phosphorylation	DYCDTYLTHDSPSVR CCCCCEECCCCCHHH	17.14	25159016
17	Phosphorylation	DTYLTHDSPSVRKTH CCEECCCCCHHHHCC	16.09	21082442
19	Phosphorylation	YLTHDSPSVRKTHCS EECCCCCHHHHCCCC	38.21	27600695
35	Succinylation	RKHKENVKDYYQKWM CCCHHHHHHHHHHHH	52.15	23954790
37	Phosphorylation	HKENVKDYYQKWMEE CHHHHHHHHHHHHHH	11.32	29514104
48	Phosphorylation	WMEEQAQSLIDKTTA HHHHHHHHHHHHHHH	30.24	14729942
52	Ubiquitination	QAQSLIDKTTAAFQQ HHHHHHHHHHHHHHC	40.56	-
52	Acetylation	QAQSLIDKTTAAFQQ HHHHHHHHHHHHHHC	40.56	-
151	Dimethylation	RPMMVPTRPGMTRPD CCCCCCCCCCCCCCC	21.50	-
151	Methylation	RPMMVPTRPGMTRPD CCCCCCCCCCCCCCC	21.50	58856461
156	Dimethylation	PTRPGMTRPDR---- CCCCCCCCCCC----	23.41	-
156	Methylation	PTRPGMTRPDR---- CCCCCCCCCCC----	23.41	58856467

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RU1C_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RU1C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RU1C_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WBP4_HUMAN	WBP4	physical	9724750
RSMB_HUMAN	SNRPB	physical	9724750

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.