dbPTM

SEP14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEP14_HUMAN
UniProt AC	Q6ZU15
Protein Name	Septin-14
Gene Name	14-Sep
Organism	Homo sapiens (Human).
Sequence Length	432
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton . Colocalizes with actin stress fibers.
Protein Description	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)..
Protein Sequence	MAERTMAMPTQIPADGDTQKENNIRCLTTIGHFGFECLPNQLVSRSIRQGFTFNILCVGETGIGKSTLIDTLFNTNLKDNKSSHFYSNVGLQIQTYELQESNVQLKLTVVETVGYGDQIDKEASYQPIVDYIDAQFEAYLQEELKIKRSLFEYHDSRVHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKADTISKNDLQTFKNKIMSELISNGIQIYQLPTDEETAAQANSSVSGLLPFAVVGSTDEVKVGKRMVRGRHYPWGVLQVENENHCDFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLQKMGFTDVGPNNQPVSFQEIFEAKRQEFYDQCQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEIRKLEEEKKQLEGEIIDFYKMKAASEALQTQLSTDTKKDKHRKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	PNQLVSRSIRQGFTF CHHHHHCHHHCCCCE	18.02	-
52	Phosphorylation	RSIRQGFTFNILCVG CHHHCCCCEEEEEEE	23.69	-
61	Phosphorylation	NILCVGETGIGKSTL EEEEEECCCCCHHHH	28.33	-
181	Ubiquitination	SLDLLTMKNLDSKVN HHCCEEECCCCCCCC	49.47	27667366
186	Ubiquitination	TMKNLDSKVNIIPLI EECCCCCCCCCHHHE	38.68	23503661
195	Ubiquitination	NIIPLIAKADTISKN CCHHHEECCCCCCHH	39.54	-
217	Phosphorylation	KIMSELISNGIQIYQ HHHHHHHHCCCEEEE	41.44	-
366	Phosphorylation	RVKEKEATFKEAEKE HHHHHHHHHHHHHHH	36.01	-
368	Ubiquitination	KEKEATFKEAEKELQ HHHHHHHHHHHHHHH	52.22	30230243
391	Ubiquitination	IQQEEIRKLEEEKKQ HCHHHHHHHHHHHHH	66.95	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SEP14_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEP14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEP14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SEP14_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEP14_HUMAN

Related Literatures of Post-Translational Modification