DNJB8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJB8_HUMAN
• UniProt AC: Q8NHS0
• Protein Name: DnaJ homolog subfamily B member 8
• Gene Name: DNAJB8
• Organism: Homo sapiens (Human).
• Sequence Length: 232
• Protein Description: Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins..
• Protein Sequence: MANYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTPYHSPFDTGYTFRNPEDIFREFFGGLDPFSFEFWDSPFNSDRGGRGHGLRGAFSAGFGEFPAFMEAFSSFNMLGCSGGSHTTFSSTSFGGSSSGSSGFKSVMSSTEMINGHKVTTKRIVENGQERVEVEEDGQLKSVTVNGKEQLKWMDSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	EVLGVQASASPEDIK EHHCCCCCCCHHHHH	16.52	30622161
15	Phosphorylation	LGVQASASPEDIKKA HCCCCCCCHHHHHHH	26.74	30622161
50	Phosphorylation	EKKFKLVSEAYEVLS HHHHHHHHHHHHHHC	27.26	30622161
53	Phosphorylation	FKLVSEAYEVLSDSK HHHHHHHHHHHCHHH	11.52	30622161
57	Phosphorylation	SEAYEVLSDSKKRSL HHHHHHHCHHHCCCH	45.04	30622161
59	Phosphorylation	AYEVLSDSKKRSLYD HHHHHCHHHCCCHHH	36.38	30622161
61	Acetylation	EVLSDSKKRSLYDRA HHHCHHHCCCHHHHC	51.69	20159555
80	Phosphorylation	WRAGGGASTPYHSPF CCCCCCCCCCCCCCC	32.94	30622161
81	Phosphorylation	RAGGGASTPYHSPFD CCCCCCCCCCCCCCC	27.60	30622161
83	Phosphorylation	GGGASTPYHSPFDTG CCCCCCCCCCCCCCC	18.28	30622161
85	Phosphorylation	GASTPYHSPFDTGYT CCCCCCCCCCCCCCC	22.78	30622161
89	Phosphorylation	PYHSPFDTGYTFRNP CCCCCCCCCCCCCCH	32.25	30622161
91	Phosphorylation	HSPFDTGYTFRNPED CCCCCCCCCCCCHHH	12.56	25693802
92	Phosphorylation	SPFDTGYTFRNPEDI CCCCCCCCCCCHHHH	19.91	30622161
181	Phosphorylation	SGSSGFKSVMSSTEM CCCCCCCHHHHCCCE	22.31	30622161
184	Phosphorylation	SGFKSVMSSTEMING CCCCHHHHCCCEECC	31.77	30622161
185	Phosphorylation	GFKSVMSSTEMINGH CCCHHHHCCCEECCE	15.42	30622161
186	Phosphorylation	FKSVMSSTEMINGHK CCHHHHCCCEECCEE	23.43	30622161
216	Acetylation	VEEDGQLKSVTVNGK ECCCCCEEEEEECCH	34.68	20159555
219	Phosphorylation	DGQLKSVTVNGKEQL CCCEEEEEECCHHHH	18.49	24719451
223	Acetylation	KSVTVNGKEQLKWMD EEEEECCHHHHHCCC	36.76	20159555
231	Phosphorylation	EQLKWMDSK------ HHHHCCCCC------	24.94	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJB8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJB8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJB8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC4_HUMAN	HDAC4	physical	20159555
HDAC6_HUMAN	HDAC6	physical	20159555
SIR2_HUMAN	SIRT2	physical	20159555
DNJB2_HUMAN	DNAJB2	physical	26186194
SG2A1_HUMAN	SCGB2A1	physical	26186194
CI040_HUMAN	C9orf40	physical	26186194
MLF1_HUMAN	MLF1	physical	26186194
DGC14_HUMAN	DGCR14	physical	26186194
DNJB2_HUMAN	DNAJB2	physical	28514442
CI040_HUMAN	C9orf40	physical	28514442
MLF1_HUMAN	MLF1	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
SG2A1_HUMAN	SCGB2A1	physical	28514442
LCN1_HUMAN	LCN1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.