S12A3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S12A3_MOUSE
• UniProt AC: P59158
• Protein Name: Solute carrier family 12 member 3
• Gene Name: Slc12a3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1002
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein.
• Protein Description: Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (By similarity). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1. [PubMed: 26099046]
• Protein Sequence: MAELPVTELPGDALCSGRFTISTLMGGDEPPPAACDSSQPSHLTHGSTLYMRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRQGRELTDGLVEDETGTNSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASEDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTMTPGPGPCEGLACGYGWNFTECSQQRSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNREPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIGPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKRNWQSAHPATVEDYIGVLHDAFDFNYGVCVMRMREGLNVSEALQTHTTPEALIQEEQASTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQAEHTKRFEDMIAPFRLNDGFKDEATVTEMRRDCPWKISDEEINKNRIKSLRQVRLSEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLRPPVLLIRGNQENVLTFYCQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	PPPAACDSSQPSHLT CCCCCCCCCCCCCCC	30.66	19060867
38	Phosphorylation	PPAACDSSQPSHLTH CCCCCCCCCCCCCCC	32.62	19060867
41	Phosphorylation	ACDSSQPSHLTHGST CCCCCCCCCCCCCCE	24.40	22817900
44	Phosphorylation	SSQPSHLTHGSTLYM CCCCCCCCCCCEEEE	20.83	22817900
47	Phosphorylation	PSHLTHGSTLYMRTF CCCCCCCCEEEEEEC	13.97	22817900
48	Phosphorylation	SHLTHGSTLYMRTFG CCCCCCCEEEEEECC	26.88	22342722
50	Phosphorylation	LTHGSTLYMRTFGYN CCCCCEEEEEECCCC	5.66	22817900
53	Phosphorylation	GSTLYMRTFGYNTID CCEEEEEECCCCCEE	12.60	19570885
56	Phosphorylation	LYMRTFGYNTIDVVP EEEEECCCCCEEEEE	12.63	21183079
58	Phosphorylation	MRTFGYNTIDVVPAY EEECCCCCEEEEECH	15.29	19570885
65	Phosphorylation	TIDVVPAYEHYANSA CEEEEECHHHHHCCC	9.36	21082442
68	Phosphorylation	VVPAYEHYANSALPG EEECHHHHHCCCCCC	8.78	21082442
71	Phosphorylation	AYEHYANSALPGEPR CHHHHHCCCCCCCCC	24.02	19570885
79	Ubiquitination	ALPGEPRKVRPTLAD CCCCCCCCCCCCHHH	54.00	22790023
83	Phosphorylation	EPRKVRPTLADLHSF CCCCCCCCHHHHHHH	24.82	22817900
89	Phosphorylation	PTLADLHSFLKQEGS CCHHHHHHHHHHCCC	39.30	22817900
96	Phosphorylation	SFLKQEGSHLHALAF HHHHHCCCCEEEEEE	23.32	21082442
120	Phosphorylation	DGLVEDETGTNSEKS CCCEECCCCCCCCCC	62.72	21082442
122	Phosphorylation	LVEDETGTNSEKSPG CEECCCCCCCCCCCC	42.88	22817900
124	Phosphorylation	EDETGTNSEKSPGEP ECCCCCCCCCCCCCC	46.36	22817900
126	Ubiquitination	ETGTNSEKSPGEPVR CCCCCCCCCCCCCCC	62.87	22790023
127	Phosphorylation	TGTNSEKSPGEPVRF CCCCCCCCCCCCCCC	33.80	21082442
197	Ubiquitination	ISTNGKVKSGGTYFL EEECCEECCCCEEEE	47.04	22790023
307	Phosphorylation	VGTLIPASEDKASKG HHCCCCCCCCCHHCC	40.76	-
404	N-linked_Glycosylation	RDASGDVNDTMTPGP ECCCCCCCCCCCCCC	43.72	-
424	N-linked_Glycosylation	LACGYGWNFTECSQQ CCCCCCCCCHHHHCC	29.60	-
542	N-linked_Glycosylation	LCSYALINFSCFHAS HHHHHHHCHHHEECC	24.51	-
704	Ubiquitination	WLNKRKIKAFYSDVI HHCHHHHHHHHHHHH	35.16	22790023
726	Phosphorylation	VQILMQASGLGRMKP HHHHHHHCCCCCCCC	20.05	25263469
779	N-linked_Glycosylation	MRMREGLNVSEALQT EHHCCCCCHHHHHHH	46.23	-
809	Ubiquitination	IFQSEQGKKTIDIYW HHHCCCCCCEEEEEE	46.57	22790023
858	Ubiquitination	NRMDEERKAIISLLS CCCCHHHHHHHHHHH	47.41	22790023
865	Phosphorylation	KAIISLLSKFRLGFH HHHHHHHHHHCCCCC	34.73	29109428
883	Ubiquitination	VLPDINQKPQAEHTK ECCCCCCCCCHHHHH	34.31	22790023
890	Ubiquitination	KPQAEHTKRFEDMIA CCCHHHHHHHHHHCC	57.93	22790023
906	Ubiquitination	FRLNDGFKDEATVTE CCCCCCCCCCCCHHH	61.25	22790023
921	Ubiquitination	MRRDCPWKISDEEIN HHHHCCCCCCHHHHH	19.92	22790023
929	Ubiquitination	ISDEEINKNRIKSLR CCHHHHHHHHHHHHH	53.95	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
48	T	Phosphorylation	Kinase	WNK4	Q96J92	PSP
58	T	Phosphorylation	Kinase	STLK3	Q9Z1W9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S12A3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S12A3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP74_HUMAN	HSPA4	physical	22027832
OS9_HUMAN	OS9	physical	26721884

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.