DDIAS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDIAS_HUMAN
• UniProt AC: Q8IXT1
• Protein Name: DNA damage-induced apoptosis suppressor protein
• Gene Name: DDIAS
• Organism: Homo sapiens (Human).
• Sequence Length: 998
• Subcellular Localization: Cytoplasm. Nucleus. Accumulates in the nucleus in response to stress..
• Protein Description: May be an anti-apoptotic protein involved in DNA repair or cell survival..
• Protein Sequence: MNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKCGSTGESGNANYRYKLSLKVAESNKLFVITVFGSCLDTFFGLTATGLHRYIQDPNKIPETLDNDTTQNLLTKAVETCFVGQSFIFGVTNFENQPGQGSDASNFLQQCSDHKRKAKALVACQIVLPDPGIAGFTVIDYFHQLLQTFNFRKLQCDSQAPNNHLLALDHSNSDLSSIYTSDSTSDFFKSCSKDTFSKFWQPSLEFTCIVSQLTDNDDFSASEQSKAFGTLQQNRKSISIAEATGSSSCHDPIQDSWSLVSYMDKKSTAEKLGKELGLQAKELSAVHSSHHEIGVNDSNLFSLEMREPLESSNTKSFHSAVEIKNRSQHELPCFQHHGIDTPTSLQKRSACCPPSLLRLEETASSSQDGDPQIWDDLPFSESLNKFLAVLESEIAVTQADVSSRKHHVDNDIDKFHADHSRLSVTPQRTTGALHTPPIALRSSQVIVKANCSKDDFLFNCKGNLSPSVEKESQPDNKVEAVSVNHNGRDMSEYFLPNPYLSALSSSSKDLETIVTLKKTIRISPHRESDHSSLNNKYLNGCGEISVSEMNEKLTTLCYRKYNDVSDLCKLENKQYCRWSKNQDDSFTICRKLTYPLETLCNSPNRSTNTLKEMPWGHINNNVTQSYSIGYEGSYDASADLFDDIAKEMDIATEITKKSQDILLKWGTSLAESHPSESDFSLRSLSEDFIQPSQKLSLQSLSDSRHSRTCSPTPHFQSDSEYNFENSQDFVPCSQSTPISGFHQTRIHGINRAFKKPVFYSDLDGNYEKIRIFPENDKQQASPSCPKNIKTPSQKIRSPIVSGVSQPDVFNHYPFAECHETDSDEWVPPTTQKIFPSDMLGFQGIGLGKCLAAYHFPDQQELPRKKLKHIRQGTNKGLIKKKLKNMLAAVVTKKKTHKYNCKSSGWISKCPDIQVLAAPQLHPILGPDSCSEVKCCLPFSEKGPPSVCETRSAWSPELFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RRKFLLASVLALQNS HHHHHHHHHHHHHCC		-
22	Phosphorylation	LQNSSFIYPSCQKCF HHCCCCCCHHHHHHH		22817900
24	Phosphorylation	NSSFIYPSCQKCFSR CCCCCCHHHHHHHHH		-
39	Phosphorylation	IILVSKRSNCPKCGS HEEEECCCCCCCCCC		-
46	Phosphorylation	SNCPKCGSTGESGNA CCCCCCCCCCCCCCC		-
47	Phosphorylation	NCPKCGSTGESGNAN CCCCCCCCCCCCCCC		-
60	Phosphorylation	ANYRYKLSLKVAESN CCCEEEEEEEEECCC		29083192
66	Phosphorylation	LSLKVAESNKLFVIT EEEEEECCCCEEEEE		29083192
73	Phosphorylation	SNKLFVITVFGSCLD CCCEEEEEEEHHHHH		29083192
355	Phosphorylation	LESSNTKSFHSAVEI CCCCCCCCCCEEEEE		25159151
358	Phosphorylation	SNTKSFHSAVEIKNR CCCCCCCEEEEECCC		25159151
386	Ubiquitination	DTPTSLQKRSACCPP CCCCHHHHHHCCCCH		-
462	Phosphorylation	HADHSRLSVTPQRTT CCCCCCEECCCCCCC		24719451
464	Phosphorylation	DHSRLSVTPQRTTGA CCCCEECCCCCCCCC		24719451
468	Phosphorylation	LSVTPQRTTGALHTP EECCCCCCCCCCCCC		22210691
469	Phosphorylation	SVTPQRTTGALHTPP ECCCCCCCCCCCCCC		22210691
474	Phosphorylation	RTTGALHTPPIALRS CCCCCCCCCCEEEEC		22210691
492	Ubiquitination	IVKANCSKDDFLFNC EEECCCCCCCEEEEC		-
500	Ubiquitination	DDFLFNCKGNLSPSV CCEEEECCCCCCCCC		-
504	Phosphorylation	FNCKGNLSPSVEKES EECCCCCCCCCCCCC		-
506	Phosphorylation	CKGNLSPSVEKESQP CCCCCCCCCCCCCCC		-
511	Phosphorylation	SPSVEKESQPDNKVE CCCCCCCCCCCCCEE		-
521	Phosphorylation	DNKVEAVSVNHNGRD CCCEEEEEECCCCCC		25159151
530	Phosphorylation	NHNGRDMSEYFLPNP CCCCCCHHHHCCCCH		28634298
532	Phosphorylation	NGRDMSEYFLPNPYL CCCCHHHHCCCCHHH		28634298
538	Phosphorylation	EYFLPNPYLSALSSS HHCCCCHHHHHHHCC		28634298
540	Phosphorylation	FLPNPYLSALSSSSK CCCCHHHHHHHCCCC		28634298
543	Phosphorylation	NPYLSALSSSSKDLE CHHHHHHHCCCCCHH		28634298
544	Phosphorylation	PYLSALSSSSKDLET HHHHHHHCCCCCHHH		22817900
545	Phosphorylation	YLSALSSSSKDLETI HHHHHHCCCCCHHHH		22817900
546	Phosphorylation	LSALSSSSKDLETIV HHHHHCCCCCHHHHH		22817900
551	Phosphorylation	SSSKDLETIVTLKKT CCCCCHHHHHEEEEE		28634298
554	Phosphorylation	KDLETIVTLKKTIRI CCHHHHHEEEEEEEE		28634298
584	Phosphorylation	LNGCGEISVSEMNEK CCCCCEECHHHHHHH		26074081
586	Phosphorylation	GCGEISVSEMNEKLT CCCEECHHHHHHHHH		26074081
604	Phosphorylation	YRKYNDVSDLCKLEN HHHCCCHHHHHHHCC		21815630
619	Ubiquitination	KQYCRWSKNQDDSFT CCCCCCCCCCCCCCC		-
624	Phosphorylation	WSKNQDDSFTICRKL CCCCCCCCCCHHHHC		21815630
641	Phosphorylation	PLETLCNSPNRSTNT CHHHHCCCCCCCCCC		25159151
733	Ubiquitination	DFIQPSQKLSLQSLS CCCCHHHCCCHHHHC		-
794	Ubiquitination	GINRAFKKPVFYSDL CCHHHHCCCEEEECC		-
799	Phosphorylation	FKKPVFYSDLDGNYE HCCCEEEECCCCCCE		27642862
805	Phosphorylation	YSDLDGNYEKIRIFP EECCCCCCEEEEECC		27642862
807	Ubiquitination	DLDGNYEKIRIFPEN CCCCCCEEEEECCCC		-
918	Acetylation	GTNKGLIKKKLKNML CCCHHHHHHHHHHHH		7696649
931	Methylation	MLAAVVTKKKTHKYN HHHHHHCCCCCCCCC		-
931	Trimethylation	MLAAVVTKKKTHKYN HHHHHHCCCCCCCCC		-
993	Phosphorylation	CETRSAWSPELFS-- CCCCCCCCHHHCC--		25159151
998	Phosphorylation	AWSPELFS------- CCCHHHCC-------		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDIAS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDIAS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDIAS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	28079882
FBLN3_HUMAN	EFEMP1	physical	28079882
ECM1_HUMAN	ECM1	physical	28079882
FBLN1_HUMAN	FBLN1	physical	28079882
CBY1_HUMAN	CBY1	physical	28079882
MI4GD_HUMAN	MIF4GD	physical	28079882
ACTN4_HUMAN	ACTN4	physical	28079882
ACTN1_HUMAN	ACTN1	physical	28079882
MAF1_HUMAN	MAF1	physical	28079882
PLS1_HUMAN	PLSCR1	physical	28079882
ACLY_HUMAN	ACLY	physical	28079882
HSP74_HUMAN	HSPA4	physical	28079882

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.