GPR22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPR22_HUMAN
• UniProt AC: Q99680
• Protein Name: Probable G-protein coupled receptor 22
• Gene Name: GPR22
• Organism: Homo sapiens (Human).
• Sequence Length: 433
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Orphan receptor..
• Protein Sequence: MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSEIREKCLVPQVVTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	N-linked_Glycosylation	INMQSESNITVRDDI EECCCCCCCEECCCH	29.87	UniProtKB CARBOHYD
192	N-linked_Glycosylation	QSGNTWENKTLLCVS CCCCCCCCCEEEEEE	33.89	UniProtKB CARBOHYD
241	Methylation	ILQALNIRIGTRFST HHHHHCCCCCCCCCC	21.88	-
259	Phosphorylation	KKARKKKTISLTTQH CCCCCCCEEEEEECC	25.36	24043423
261	Phosphorylation	ARKKKTISLTTQHEA CCCCCEEEEEECCCC	25.54	24043423
263	Phosphorylation	KKKTISLTTQHEATD CCCEEEEEECCCCCC	20.02	24043423
264	Phosphorylation	KKTISLTTQHEATDM CCEEEEEECCCCCCC	32.97	24043423
269	Phosphorylation	LTTQHEATDMSQSSG EEECCCCCCCHHHCC	29.29	24043423
272	Phosphorylation	QHEATDMSQSSGGRN CCCCCCCHHHCCCCC	29.71	24043423
274	Phosphorylation	EATDMSQSSGGRNVV CCCCCHHHCCCCCEE	24.52	24043423
275	Phosphorylation	ATDMSQSSGGRNVVF CCCCHHHCCCCCEEE	37.32	24043423
419	Phosphorylation	KKITFEDSEIREKCL CCCCCCCHHHHHHHC	27.94	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPR22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPR22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPR22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFAC4_HUMAN	NFATC4	physical	21988832
AP2C_HUMAN	TFAP2C	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.