dbPTM

IL7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IL7_HUMAN
UniProt AC	P13232
Protein Name	Interleukin-7
Gene Name	IL7
Organism	Homo sapiens (Human).
Sequence Length	177
Subcellular Localization	Secreted.
Protein Description	Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation..
Protein Sequence	MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	EGKDGKQYESVLMVS CCCCCCEEEEEEEEE	17.41	26853621
39	Phosphorylation	KDGKQYESVLMVSID CCCCEEEEEEEEEHH	18.67	26853621
44	Phosphorylation	YESVLMVSIDQLLDS EEEEEEEEHHHHHHH	13.39	26853621
51	Phosphorylation	SIDQLLDSMKEIGSN EHHHHHHHHHHHCHH	31.55	26853621
95	N-linked_Glycosylation	LRQFLKMNSTGDFDL HHHHHHCCCCCCCCE	34.53	UniProtKB CARBOHYD
116	N-linked_Glycosylation	EGTTILLNCTGQVKG CCCEEEEECCCCCCC	20.19	UniProtKB CARBOHYD
141	N-linked_Glycosylation	PTKSLEENKSLKEQK CCCCHHHCCCHHHHH	29.82	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IL7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IL7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IL7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IL7_HUMAN

Related Literatures of Post-Translational Modification