MTHSD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTHSD_HUMAN
• UniProt AC: Q2M296
• Protein Name: Methenyltetrahydrofolate synthase domain-containing protein
• Gene Name: MTHFSD
• Organism: Homo sapiens (Human).
• Sequence Length: 383
• Protein Sequence: MEPRAVGVSKQDIREQIWGYMESQNLADFPRPVHHRIPNFKGSYLACQNIKDLDVFARTQEVKVDPDKPLEGVRLLVLQSKKTLLVPTPRLRTGLFNKITPPPGATKDILRKCATSQGVRNYSVPIGLDSRVLVDLVVVGSVAVSEKGWRIGKGEGYADLEYAMMVSMGAVSKETPVVTIVHDCQVVDIPEELVEEHDITVDYILTPTRVIATGCKRPKPMGITWFKISLEMMEKIPILRSLRAREQQAGKDVTLQGEHQHLPEPGCQQTVPLSVGRRPPDTPGPETNSMEAAPGSPPGEGAPLAADVYVGNLPGDARVSDLKRALRELGSVPLRLTWQGPRRRAFLHYPDSAAAQQAVSCLQGLRLGTDTLRVALARQQRDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Methylation	HHRIPNFKGSYLACQ CCCCCCCCCCEEEEC	54.29	-
51	Ubiquitination	YLACQNIKDLDVFAR EEEECCCCCCEEEEE	60.84	-
63	Ubiquitination	FARTQEVKVDPDKPL EEEEEEEECCCCCCC	39.92	-
80	Phosphorylation	VRLLVLQSKKTLLVP EEEEEEECCCEEEEE	31.77	22496350
83	Phosphorylation	LVLQSKKTLLVPTPR EEEECCCEEEEECCC	29.12	20393185
88	Phosphorylation	KKTLLVPTPRLRTGL CCEEEEECCCCCCCC	17.35	-
122	Phosphorylation	TSQGVRNYSVPIGLD HCCCCCCCCCCCCCC	10.65	26552605
123	Phosphorylation	SQGVRNYSVPIGLDS CCCCCCCCCCCCCCH	25.60	26552605
130	Phosphorylation	SVPIGLDSRVLVDLV CCCCCCCHHHEEEEE	29.36	26552605
172	Phosphorylation	MVSMGAVSKETPVVT EHHHCCCCCCCCCEE	25.00	23532336
206	Phosphorylation	ITVDYILTPTRVIAT CEEEEEECCCEEEEC	17.04	24719451
296	Phosphorylation	SMEAAPGSPPGEGAP CCCCCCCCCCCCCCC	27.19	25159151
309	Phosphorylation	APLAADVYVGNLPGD CCCCCEEEECCCCCC	11.82	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTHSD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTHSD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTHSD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S23IP_HUMAN	SEC23IP	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.