CBPC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBPC2_HUMAN
• UniProt AC: Q5U5Z8
• Protein Name: Cytosolic carboxypeptidase 2
• Gene Name: AGBL2
• Organism: Homo sapiens (Human).
• Sequence Length: 902
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ci
• Protein Description: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin..
• Protein Sequence: MFPALETHLKQTIPDPYEDFMYRHLQYYGYFKAQRGSLPNSATHQHVRKNNPQCLLNGSLGEKDDLIPDTLQKEKLLWPISLSSAVHRQIEAINRDFHSCLGWMQWRGLSSLQPPPPRFKDSPASAFRVAGITDSHMLSLPHLRSRQLLYDELDEVNPRLREPQELFSILSTKRPLQAPRWPIECEVIKENIHHIEWAPPQPEYFYQPKGNEKVPEIVGEKKGTVVYQLDSVPIEGSYFTSSRVGGKRGIVKELAVTLQGPEDNTLLFESRFESGNLQKAVRVDTYEYELTLRTDLYTNKHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYTVGMKPLLYSQLDANTRNIGWRREGNEIKYYKNNTDDGQQPFYCLTWTIQFPYDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAAAKKAVVLSARVHPGESNGSWVMKGFLDFILSNSPDAQLLRDIFVFKVLPMLNPDGVIVGNYRCSLAGRDLNRHYKTILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCNNNNRKYWLHERVFPLMLCKNAPDKFSFHSCNFKVQKCKEGTGRVVMWRMGILNSYTMESTFGGSTLGNKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQMKFTQCLAELKELLRQEIHKKFHELGQDVDLEGSWSDISLSDIESSTSGSDSSLSDGLPVHLANIADELTQKKKMFKKKKKKSLQTRKQRNEQYQKKNLMQKLKLTEDTSEKAGFASTLQKQPTFFKNSENSSFLPMKNENPRLNETNLNRRDKDTPLDPSMATLILPKNKGRMQNKKPGFTVSCSPKRTINSSQEPAPGMKPNWPRSRYPATKRGCAAMAAYPSLHIYTYP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MFPALETHLKQTIP -CCCHHHHHHHHHCC	33.10	28634298
12	Phosphorylation	LETHLKQTIPDPYED HHHHHHHHCCCCHHH	32.65	28634298
17	Phosphorylation	KQTIPDPYEDFMYRH HHHCCCCHHHHHHHH	35.20	28634298
22	Phosphorylation	DPYEDFMYRHLQYYG CCHHHHHHHHHHHHC	8.55	28634298
111	Phosphorylation	MQWRGLSSLQPPPPR HHHCCHHHCCCCCCC	35.75	46160297
171	Phosphorylation	QELFSILSTKRPLQA HHHHHHHHCCCCCCC	30.16	24719451
257	Phosphorylation	IVKELAVTLQGPEDN EEEEEEEEEECCCCC	14.04	30622161
524	Phosphorylation	GRDLNRHYKTILKES CCCHHHHHHHHHHHH	13.44	113320523
526	Phosphorylation	DLNRHYKTILKESFP CHHHHHHHHHHHHCC	25.11	28348404
537	Phosphorylation	ESFPCIWYTRNMIKR HHCCHHHHCHHHHHH	3.95	27251275
538	Phosphorylation	SFPCIWYTRNMIKRL HCCHHHHCHHHHHHH	10.69	28348404
563	Acetylation	DFHGHSRKNNIFLYG CCCCCCCCCCEEEEE	58.31	7962689
577	Acetylation	GCNNNNRKYWLHERV ECCCCCCEEEEECCH	42.79	7962699
636	Phosphorylation	MESTFGGSTLGNKRD EEECCCCCCCCCCCC	22.34	68737177
644	Phosphorylation	TLGNKRDTHFTIEDL CCCCCCCCCEEHHHH	23.95	46160307
647	Phosphorylation	NKRDTHFTIEDLKSL CCCCCCEEHHHHHHC	18.82	46160313
847	Acetylation	NKGRMQNKKPGFTVS CCCCCCCCCCCCEEE	43.37	7338887
858	Acetylation	FTVSCSPKRTINSSQ CEEECCCCCCCCCCC	45.97	7338897
864	Phosphorylation	PKRTINSSQEPAPGM CCCCCCCCCCCCCCC	33.79	46160301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBPC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBPC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBPC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPM2_HUMAN	TPM2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.