KCTD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCTD1_HUMAN
• UniProt AC: Q719H9
• Protein Name: BTB/POZ domain-containing protein KCTD1
• Gene Name: KCTD1
• Organism: Homo sapiens (Human).
• Sequence Length: 257
• Subcellular Localization: Nucleus .
• Protein Description: May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent..
• Protein Sequence: MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELRRTPRVPSVIRIKQEPLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRPLITRS ------CCCCCCCCC	42.48	22199227
7	Phosphorylation	-MSRPLITRSPASPL -CCCCCCCCCCCCCC	32.55	22199227
9	Phosphorylation	SRPLITRSPASPLNN CCCCCCCCCCCCCCC	19.03	28355574
12	Phosphorylation	LITRSPASPLNNQGI CCCCCCCCCCCCCCC	33.05	28355574
15	Phosphorylation	RSPASPLNNQGIPTP CCCCCCCCCCCCCCH	42.01	27251275
17	Phosphorylation	PASPLNNQGIPTPAQ CCCCCCCCCCCCHHH	50.55	27251275
20	Phosphorylation	PLNNQGIPTPAQLTK CCCCCCCCCHHHHCC	38.87	27251275
21	Phosphorylation	LNNQGIPTPAQLTKS CCCCCCCCHHHHCCC	29.36	20068231
26	Phosphorylation	IPTPAQLTKSNAPVH CCCHHHHCCCCCCEE	21.98	20873877
43	Phosphorylation	VGGHMYTSSLATLTK ECCCEEECCHHHHHC	13.08	-
44	Phosphorylation	GGHMYTSSLATLTKY CCCEEECCHHHHHCC	17.77	-
47	Phosphorylation	MYTSSLATLTKYPES EEECCHHHHHCCCHH	40.01	-
247	Phosphorylation	RRTPRVPSVIRIKQE HCCCCCCCEEEEECC	27.59	24719451
252	Sumoylation	VPSVIRIKQEPLD-- CCCEEEEECCCCC--	38.47	-
617	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		18669648
620	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		18669648
629	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
634	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
855	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
860	Sumoylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCTD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCTD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCTD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2A_HUMAN	TFAP2A	physical	19115315
AP2B_HUMAN	TFAP2B	physical	19115315
AP2C_HUMAN	TFAP2C	physical	19115315
CTNB1_HUMAN	CTNNB1	physical	24736394
APC_HUMAN	APC	genetic	24736394
KCTD1_HUMAN	KCTD1	physical	25416956
UBC9_HUMAN	UBE2I	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 181270: Scalp-ear-nipple syndrome (SENS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-12, AND MASSSPECTROMETRY.
PubMed: 18669648