NOE3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOE3_HUMAN
• UniProt AC: Q96PB7
• Protein Name: Noelin-3
• Gene Name: OLFM3
• Organism: Homo sapiens (Human).
• Sequence Length: 478
• Subcellular Localization: Secreted. Cell junction, synapse.
• Protein Sequence: MSPPLLKLGAVLSTMAMISNWMSQTLPSLVGLNTTRLSTPDTLTQISPKEGWQVYSSAQDPDGRCICTVVAPEQNLCSRDAKSRQLRQLLEKVQNMSQSIEVLNLRTQRDFQYVLKMETQMKGLKAKFRQIEDDRKTLMTKHFQELKEKMDELLPLIPVLEQYKTDAKLITQFKEEIRNLSAVLTGIQEEIGAYDYEELHQRVLSLETRLRDCMKKLTCGKLMKITGPVTVKTSGTRFGAWMTDPLASEKNNRVWYMDSYTNNKIVREYKSIADFVSGAESRTYNLPFKWAGTNHVVYNGSLYFNKYQSNIIIKYSFDMGRVLAQRSLEYAGFHNVYPYTWGGFSDIDLMADEIGLWAVYATNQNAGNIVISQLNQDTLEVMKSWSTGYPKRSAGESFMICGTLYVTNSHLTGAKVYYSYSTKTSTYEYTDIPFHNQYFHISMLDYNARDRALYAWNNGHQVLFNVTLFHIIKTEDDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPPLLKLG ------CCCCHHHHH	34.91	21815630
4 (in isoform 6)	Phosphorylation	-	42.91	22496350
4 (in isoform 5)	Phosphorylation	-	42.91	22496350
4 (in isoform 4)	Phosphorylation	-	42.91	24043423
4 (in isoform 3)	Phosphorylation	-	42.91	24043423
5 (in isoform 4)	Phosphorylation	-	8.17	24043423
5 (in isoform 3)	Phosphorylation	-	8.17	24043423
14 (in isoform 4)	Phosphorylation	-	12.56	24043423
14 (in isoform 3)	Phosphorylation	-	12.56	24043423
22 (in isoform 4)	Phosphorylation	-	2.20	24043423
22 (in isoform 3)	Phosphorylation	-	2.20	24043423
33	N-linked_Glycosylation	LPSLVGLNTTRLSTP HHHHCCCCCCCCCCC	33.21	UniProtKB CARBOHYD
95	N-linked_Glycosylation	QLLEKVQNMSQSIEV HHHHHHHHHHHHEEE	34.75	UniProtKB CARBOHYD
97	Phosphorylation	LEKVQNMSQSIEVLN HHHHHHHHHHEEEEE	28.46	30622161
99	Phosphorylation	KVQNMSQSIEVLNLR HHHHHHHHEEEEECC	17.26	24043423
137	Phosphorylation	QIEDDRKTLMTKHFQ HHHHHHHHHHHHHHH	23.74	29449344
140	Phosphorylation	DDRKTLMTKHFQELK HHHHHHHHHHHHHHH	25.20	19413330
149	Acetylation	HFQELKEKMDELLPL HHHHHHHHHHHHHHH	50.49	20167786
179	N-linked_Glycosylation	QFKEEIRNLSAVLTG HHHHHHHHHHHHHHH	43.97	UniProtKB CARBOHYD
230	Phosphorylation	MKITGPVTVKTSGTR EEEECCEEEEECCCC	21.30	23403867
233	Phosphorylation	TGPVTVKTSGTRFGA ECCEEEEECCCCCEE	28.22	23403867
234	Phosphorylation	GPVTVKTSGTRFGAW CCEEEEECCCCCEEE	32.23	23403867
236	Phosphorylation	VTVKTSGTRFGAWMT EEEEECCCCCEEEEC	23.69	23403867
259	Phosphorylation	NRVWYMDSYTNNKIV CEEEEEECCCCCHHH	19.82	30576142
299	N-linked_Glycosylation	GTNHVVYNGSLYFNK CCCEEEEECEEEEEC	23.20	UniProtKB CARBOHYD
465	N-linked_Glycosylation	NGHQVLFNVTLFHII CCEEEEEEEEEEEEE	23.00	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOE3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOE3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOE3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYOC_HUMAN	MYOC	physical	12019210
A4_HUMAN	APP	physical	21832049
NOE2_HUMAN	OLFM2	physical	28514442
BRE1A_HUMAN	RNF20	physical	28514442
LRP1B_HUMAN	LRP1B	physical	28514442
EHD4_HUMAN	EHD4	physical	28514442
AGRIN_HUMAN	AGRN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140, AND MASSSPECTROMETRY.
PubMed: 19413330