DLK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLK2_HUMAN
• UniProt AC: Q6UY11
• Protein Name: Protein delta homolog 2
• Gene Name: DLK2
• Organism: Homo sapiens (Human).
• Sequence Length: 383
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Regulates adipogenesis..
• Protein Sequence: MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQVSMLPAGLPLPRDLPPEPGKTTAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
157	N-linked_Glycosylation	DDQGFALNFTCRCLV CCCCCCCEEEEHHHH	27.10	UniProtKB CARBOHYD
275	O-linked_Glycosylation	SAVVVPATGPAPHSA EEEEEECCCCCCCCC	37.31	OGP
281	O-linked_Glycosylation	ATGPAPHSAGAGLLR CCCCCCCCCCCCEEE	27.60	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DLK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
A4_HUMAN	APP	physical	21832049
RN213_HUMAN	RNF213	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442
RBG10_HUMAN	RABGAP1L	physical	28514442
RBG1L_HUMAN	RABGAP1L	physical	28514442
TARB1_HUMAN	TARBP1	physical	28514442
S22AN_HUMAN	SLC22A23	physical	28514442
VEZA_HUMAN	VEZT	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
NOTC3_HUMAN	NOTCH3	physical	28514442
NOTC1_HUMAN	NOTCH1	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
CTR2_HUMAN	SLC7A2	physical	28514442
LDLR_HUMAN	LDLR	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
LRC8A_HUMAN	LRRC8A	physical	28514442
LRC8E_HUMAN	LRRC8E	physical	28514442
RBGP1_HUMAN	RABGAP1	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442
ALG5_HUMAN	ALG5	physical	28514442
GBF1_HUMAN	GBF1	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
LRBA_HUMAN	LRBA	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
LRP2_HUMAN	LRP2	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.