S6A20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S6A20_HUMAN
• UniProt AC: Q9NP91
• Protein Name: Sodium- and chloride-dependent transporter XTRP3
• Gene Name: SLC6A20
• Organism: Homo sapiens (Human).
• Sequence Length: 592
• Subcellular Localization: Apical cell membrane; Multi-pass membrane protein. Located in the apical brush border membrane of kidney proximal tubule cells..
• Protein Description: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine..
• Protein Sequence: MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	GQRMRQGSIGAWRTI HHHHHCCCCCCHHHC	14.98	29970186
131	N-linked_Glycosylation	SVCPLNGNHTGYDEE CCCCCCCCCCCCCHH	28.59	UniProtKB CARBOHYD
189	Phosphorylation	YLCILRGTESTGKVV HHHHHHCCCCCCCEE	21.96	23663014
191	Phosphorylation	CILRGTESTGKVVYF HHHHCCCCCCCEEEE	42.15	23663014
192	Phosphorylation	ILRGTESTGKVVYFT HHHCCCCCCCEEEEE	34.49	23663014
197	Phosphorylation	ESTGKVVYFTASLPY CCCCCEEEEECCHHH	9.74	23663014
199	Phosphorylation	TGKVVYFTASLPYCV CCCEEEEECCHHHHH	9.54	23663014
201	Phosphorylation	KVVYFTASLPYCVLI CEEEEECCHHHHHHH	27.15	23663014
204	Phosphorylation	YFTASLPYCVLIIYL EEECCHHHHHHHHHH	10.65	23663014
210	Phosphorylation	PYCVLIIYLIRGLTL HHHHHHHHHHHCHHH	6.78	23663014
221	Phosphorylation	GLTLHGATNGLMYMF CHHHHCCCCCCHHCC	34.12	27251275
229	Phosphorylation	NGLMYMFTPKIEQLA CCCHHCCCHHHHHHC	13.72	27251275
303	Phosphorylation	SIYGFKATFNYENCL HHHCHHEEECHHHHH	17.01	-
306	Phosphorylation	GFKATFNYENCLKKV CHHEEECHHHHHHHH	12.34	-
339	Phosphorylation	NLEQVKGYLASAYPS CHHHHHHHHHHHCCH	8.06	-
342	Phosphorylation	QVKGYLASAYPSKYS HHHHHHHHHCCHHHH	26.24	-
357	N-linked_Glycosylation	EMFPQIKNCSLESEL HHCHHHCCCCCHHHH	23.41	UniProtKB CARBOHYD
379	Phosphorylation	GLAFIVYTEAIKNME CEEEEEEHHHHHCCC	14.19	26074081
388	Phosphorylation	AIKNMEVSQLWSVLY HHHCCCHHHHHHHHH	13.27	26074081
392	Phosphorylation	MEVSQLWSVLYFFML CCHHHHHHHHHHHHH	15.73	26074081
497	Phosphorylation	ESDLKAMTGRAVSWY HHHHHHHHCCHHHHH	28.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S6A20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S6A20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S6A20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.