ZEP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZEP3_HUMAN
• UniProt AC: Q5T1R4
• Protein Name: Transcription factor HIVEP3
• Gene Name: HIVEP3
• Organism: Homo sapiens (Human).
• Sequence Length: 2406
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation..
• Protein Sequence: MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPGEEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRRSASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEALKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEERRGEPEEDAPASQRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEDEDEEESQDELSRPSSEAPPPGPPHALRADSSPILGPQPPDAPASGTEATRGSSVSEAERLTASSCSMSSQSMPGLPWLGPAPLGSVEKDTGSALSYKPVSPRRPWSPSKEAGSRPPLARKHSLTKNDSSPQRCSPAREPQASAPSPPGLHVDPGRGMGALPCGSPRLQLSPLTLCPLGRELAPRAHVLSKLEGTTDPGLPRYSPTRRWSPGQAESPPRSAPPGKWALAGPGSPSAGEHGPGLGLDPRVLFPPAPLPHKLLSRSPETCASPWQKAESRSPSCSPGPAHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRAPCPLIPIGGIQMVQARPGAHPTLLPGPTAAWVSGFSGGGSDLTGAREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEGGDYPKERERTGGGPGRPPDWTPHGTGAPAEPTPTHSPCTPPDTLPRPPQGRRAAQSWSPRLESPRAPTNPEPSATPPLDRSSSVGCLAEASARFPARTRNLSGEPRTRQDSPKPSGSGEPRAHPHQPEDRVPPNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	GTKKAEGSPRKRLTK CCCCCCCCCCCCCCC	17.03	23403867
93	Phosphorylation	IEASVHISQLPQHPL CCCEEEHHHCCCCCC	15.70	28258704
101	Phosphorylation	QLPQHPLTPAFMSPG HCCCCCCCCCCCCCC	19.61	28258704
182	Acetylation	PTEEAHKKERKPQKP CCHHHHHHCCCCCCC	53.54	18530771
215	Phosphorylation	QKHIRSHTGERPYPC HHHHHHCCCCCCCCC	41.82	21712546
228	Phosphorylation	PCGPCGFSFKTKSNL CCCCCCCEEECCCCH	15.89	24719451
277	Phosphorylation	GEEFEEPTEGESTDS CCCCCCCCCCCCCCC	60.96	26074081
281	Phosphorylation	EEPTEGESTDSEEET CCCCCCCCCCCHHHH	48.66	26074081
282	Phosphorylation	EPTEGESTDSEEETS CCCCCCCCCCHHHHC	38.96	26074081
284	Phosphorylation	TEGESTDSEEETSAT CCCCCCCCHHHHCCC	47.17	26074081
313	Phosphorylation	LLSSGLYSSGSHSSS CCCCCCCCCCCCCCC	33.01	28348404
314	Phosphorylation	LSSGLYSSGSHSSSH CCCCCCCCCCCCCCC	30.66	28348404
316	Phosphorylation	SGLYSSGSHSSSHER CCCCCCCCCCCCCCC	23.34	28348404
318	Phosphorylation	LYSSGSHSSSHERCS CCCCCCCCCCCCCCC	34.92	28348404
319	Phosphorylation	YSSGSHSSSHERCSL CCCCCCCCCCCCCCC	30.23	28348404
320	Phosphorylation	SSGSHSSSHERCSLS CCCCCCCCCCCCCCC	32.17	24961811
363	Ubiquitination	DTHTIKQKLALRLSE CHHHHHHHHHHHHHH	30.63	-
382	Phosphorylation	IDEQAFLSPGSKGST CCCHHCCCCCCCCCC	22.29	24905233
385	Phosphorylation	QAFLSPGSKGSTESG HHCCCCCCCCCCCCC	36.91	27251275
393	Phosphorylation	KGSTESGYFSRSESA CCCCCCCCCCCCCCH	13.99	24275569
395	Phosphorylation	STESGYFSRSESAEQ CCCCCCCCCCCCHHC	26.81	29759185
397	Phosphorylation	ESGYFSRSESAEQQV CCCCCCCCCCHHCCC	34.40	29759185
399	Phosphorylation	GYFSRSESAEQQVSP CCCCCCCCHHCCCCC	38.05	28348404
405	Phosphorylation	ESAEQQVSPPNTNAK CCHHCCCCCCCCCHH	30.24	30108239
409	Phosphorylation	QQVSPPNTNAKSYAE CCCCCCCCCHHHHHH	42.18	30108239
455	Phosphorylation	KPSLVPLSVPRTQVI CCCCCCCCCCHHHHH	24.81	24719451
489	Phosphorylation	DSVKPRRSSLSRRSS CCCCCCCCCCHHHHC	36.59	18691976
490	Phosphorylation	SVKPRRSSLSRRSSM CCCCCCCCCHHHHCC	28.66	20068231
492	Phosphorylation	KPRRSSLSRRSSMES CCCCCCCHHHHCCCC	27.82	21406692
495	Phosphorylation	RSSLSRRSSMESPKS CCCCHHHHCCCCCCH	32.69	28985074
496	Phosphorylation	SSLSRRSSMESPKSS CCCHHHHCCCCCCHH	25.43	24719451
540	Phosphorylation	PPVPLLRSHSMPSAA CCCCCCCCCCCCCCC	21.63	30108239
542	Phosphorylation	VPLLRSHSMPSAACT CCCCCCCCCCCCCCE	33.37	30108239
545	Phosphorylation	LRSHSMPSAACTIST CCCCCCCCCCCEECC	21.62	30108239
549	Phosphorylation	SMPSAACTISTPHHP CCCCCCCEECCCCCC	17.15	23312004
551	Phosphorylation	PSAACTISTPHHPFR CCCCCEECCCCCCCC	20.10	23312004
552	Phosphorylation	SAACTISTPHHPFRG CCCCEECCCCCCCCC	23.84	23312004
560	Phosphorylation	PHHPFRGSYSFDDHI CCCCCCCCCCCCCCC	17.22	28348404
562	Phosphorylation	HPFRGSYSFDDHITD CCCCCCCCCCCCCCC	24.73	28348404
611	Acetylation	EEPGPSSKDTASKPS CCCCCCCCCCCCCCC	64.53	7431223
613	Phosphorylation	PGPSSKDTASKPSDE CCCCCCCCCCCCCCC	36.25	26074081
615	Phosphorylation	PSSKDTASKPSDEVE CCCCCCCCCCCCCCC	47.38	26074081
618	Phosphorylation	KDTASKPSDEVEPKE CCCCCCCCCCCCCCH	50.57	26074081
624	Acetylation	PSDEVEPKESELTKK CCCCCCCCHHHHCHH	61.44	7431233
626	Phosphorylation	DEVEPKESELTKKTK CCCCCCHHHHCHHHH	43.99	26074081
629	Phosphorylation	EPKESELTKKTKKGL CCCHHHHCHHHHHCC	26.83	26074081
632	Phosphorylation	ESELTKKTKKGLKTK HHHHCHHHHHCCCCC	39.27	26074081
634	Acetylation	ELTKKTKKGLKTKGV HHCHHHHHCCCCCCE	74.77	7429283
637	Acetylation	KKTKKGLKTKGVIYE HHHHHCCCCCCEEEE	57.78	7429293
639	Acetylation	TKKGLKTKGVIYECN HHHCCCCCCEEEECC	49.98	7431243
667	Phosphorylation	AHKKYYCSELQIAKP HHHHHHCCCCEECCC	25.81	30108239
676	Phosphorylation	LQIAKPISAGTHTSP CEECCCCCCCCCCCH	29.22	30108239
679	Phosphorylation	AKPISAGTHTSPEAE CCCCCCCCCCCHHHH	23.00	29255136
681	Phosphorylation	PISAGTHTSPEAEKS CCCCCCCCCHHHHHH	45.90	29255136
682	Phosphorylation	ISAGTHTSPEAEKSQ CCCCCCCCHHHHHHH	17.09	29255136
710	Phosphorylation	LGTTLELTPLRKRRK HCCCEECCCHHHHHH	15.76	24719451
720	Phosphorylation	RKRRKEKSLGDEEEP HHHHHHHCCCCCCCC	38.38	23401153
732	Phosphorylation	EEPPAFESTKSQFGS CCCCCHHCHHHHCCC	34.38	25159151
733	Phosphorylation	EPPAFESTKSQFGSP CCCCHHCHHHHCCCC	27.76	25159151
735	Phosphorylation	PAFESTKSQFGSPGP CCHHCHHHHCCCCCC	30.72	30108239
739	Phosphorylation	STKSQFGSPGPSDAA CHHHHCCCCCCCHHH	28.15	30108239
743	Phosphorylation	QFGSPGPSDAARNLP HCCCCCCCHHHHCCC	45.88	30108239
753	Phosphorylation	ARNLPLESTKSPAEP HHCCCCCCCCCCCCC	49.14	28348404
754	Phosphorylation	RNLPLESTKSPAEPS HCCCCCCCCCCCCCC	26.60	28348404
756	Phosphorylation	LPLESTKSPAEPSKS CCCCCCCCCCCCCCC	29.45	28348404
763	O-linked_Glycosylation	SPAEPSKSVPSLEGP CCCCCCCCCCCCCCC	43.53	28657654
763	Phosphorylation	SPAEPSKSVPSLEGP CCCCCCCCCCCCCCC	43.53	29449344
766	O-linked_Glycosylation	EPSKSVPSLEGPTGF CCCCCCCCCCCCCCC	36.58	28657654
766	Phosphorylation	EPSKSVPSLEGPTGF CCCCCCCCCCCCCCC	36.58	29449344
777	Phosphorylation	PTGFQPRTPKPGSGS CCCCCCCCCCCCCCC	42.20	20860994
782	Phosphorylation	PRTPKPGSGSESGKE CCCCCCCCCCCCCCC	47.90	-
784	Phosphorylation	TPKPGSGSESGKERR CCCCCCCCCCCCCCC	30.22	18452278
786	Phosphorylation	KPGSGSESGKERRTT CCCCCCCCCCCCCCC	57.79	18452278
788	Acetylation	GSGSESGKERRTTSK CCCCCCCCCCCCCCC	58.28	7407687
792	Phosphorylation	ESGKERRTTSKEISV CCCCCCCCCCCEEEE	41.46	29449344
793	Phosphorylation	SGKERRTTSKEISVI CCCCCCCCCCEEEEE	35.67	29449344
794	Phosphorylation	GKERRTTSKEISVIQ CCCCCCCCCEEEEEE	27.90	29449344
798	Phosphorylation	RTTSKEISVIQHTSS CCCCCEEEEEEECCC	17.79	28348404
803	Phosphorylation	EISVIQHTSSFEKSD EEEEEEECCCCCCCC	15.08	30266825
804	Phosphorylation	ISVIQHTSSFEKSDS EEEEEECCCCCCCCC	30.79	30266825
805	Phosphorylation	SVIQHTSSFEKSDSL EEEEECCCCCCCCCC	38.28	25849741
809	Phosphorylation	HTSSFEKSDSLEQPS ECCCCCCCCCCCCCC	25.82	25002506
811	Phosphorylation	SSFEKSDSLEQPSGL CCCCCCCCCCCCCCC	40.68	25002506
816	Phosphorylation	SDSLEQPSGLEGEDK CCCCCCCCCCCCCCC	56.56	30108239
830	Phosphorylation	KPLAQFPSPPPAPHG CCHHHCCCCCCCCCC	51.86	30108239
916	Phosphorylation	RLAEMAQSSGESSFE HHHHHHHHCCCCCCC	30.67	28348404
917	Phosphorylation	LAEMAQSSGESSFES HHHHHHHCCCCCCCC	34.20	28348404
920	Phosphorylation	MAQSSGESSFESSVP HHHHCCCCCCCCCCC	43.80	28348404
921	Phosphorylation	AQSSGESSFESSVPL HHHCCCCCCCCCCCC	28.82	28348404
931	Phosphorylation	SSVPLSRSPSQESNV CCCCCCCCCCCCCCE	26.06	25849741
933	Phosphorylation	VPLSRSPSQESNVSL CCCCCCCCCCCCEEC	48.07	29255136
936	Phosphorylation	SRSPSQESNVSLSGS CCCCCCCCCEECCCC	34.59	26852163
939	Phosphorylation	PSQESNVSLSGSSRS CCCCCCEECCCCCCC	22.52	-
943	Phosphorylation	SNVSLSGSSRSASFE CCEECCCCCCCCCCC	21.14	-
944	Phosphorylation	NVSLSGSSRSASFER CEECCCCCCCCCCCC	33.51	-
946	Phosphorylation	SLSGSSRSASFERDD ECCCCCCCCCCCCCC	30.16	27251275
948	Phosphorylation	SGSSRSASFERDDHG CCCCCCCCCCCCCCC	28.96	28102081
961	Phosphorylation	HGKAEAPSPSSDMRP CCCCCCCCCCCCCCC	44.45	28348404
977	Phosphorylation	PLGTHMLTVPSHHPH CCCCCCCCCCCCCHH	23.85	30576142
991	Phosphorylation	HAREMRRSASEQSPN HHHHHHHHHHHCCCC	26.28	28450419
993	Phosphorylation	REMRRSASEQSPNVS HHHHHHHHHCCCCCC	37.10	25849741
996	Phosphorylation	RRSASEQSPNVSHSA HHHHHHCCCCCCCCC	17.87	29978859
1000	Phosphorylation	SEQSPNVSHSAHMTE HHCCCCCCCCCCCCC	20.54	24114839
1002	Phosphorylation	QSPNVSHSAHMTETR CCCCCCCCCCCCCCC	16.62	27732954
1006	Phosphorylation	VSHSAHMTETRSKSF CCCCCCCCCCCCCCC	25.08	23312004
1008	Phosphorylation	HSAHMTETRSKSFDY CCCCCCCCCCCCCCC	30.95	23312004
1010	Phosphorylation	AHMTETRSKSFDYGS CCCCCCCCCCCCCCC	39.82	23663014
1012	Phosphorylation	MTETRSKSFDYGSLS CCCCCCCCCCCCCCC	25.29	22115753
1015	Phosphorylation	TRSKSFDYGSLSLTG CCCCCCCCCCCCCCC	13.45	23663014
1017	Phosphorylation	SKSFDYGSLSLTGPS CCCCCCCCCCCCCCC	14.46	23663014
1019	Phosphorylation	SFDYGSLSLTGPSAP CCCCCCCCCCCCCCC	26.11	23663014
1021	Phosphorylation	DYGSLSLTGPSAPAP CCCCCCCCCCCCCCC	43.61	23663014
1024	Phosphorylation	SLSLTGPSAPAPVAP CCCCCCCCCCCCCCC	48.51	30108239
1050	Phosphorylation	CFLVRQASLSRPPES EEEEEEHHCCCCCHH	20.66	29255136
1052	Phosphorylation	LVRQASLSRPPESEL EEEEHHCCCCCHHHC	40.00	29255136
1057	Phosphorylation	SLSRPPESELEVAPK HCCCCCHHHCEECCC	53.94	27486199
1069	Phosphorylation	APKGRQESEEPQPSS CCCCCCCCCCCCCCC	38.63	-
1075	O-linked_Glycosylation	ESEEPQPSSSKPSAK CCCCCCCCCCCCCHH	41.83	28657654
1076	O-linked_Glycosylation	SEEPQPSSSKPSAKS CCCCCCCCCCCCHHH	49.41	28657654
1077	O-linked_Glycosylation	EEPQPSSSKPSAKSS CCCCCCCCCCCHHHH	53.58	28657654
1080	O-linked_Glycosylation	QPSSSKPSAKSSLSQ CCCCCCCCHHHHHHH	52.65	28657654
1270	Phosphorylation	TSLAPLATGSAGLSP HHHHHCCCCCCCCCC	39.08	28348404
1272	Phosphorylation	LAPLATGSAGLSPST HHHCCCCCCCCCCCC	18.14	28348404
1276	Phosphorylation	ATGSAGLSPSTEYSS CCCCCCCCCCCCCCC	18.84	28348404
1401	O-linked_Glycosylation	PYLRVPVTLPERKGT CCEECEECCCCCCCC	30.44	28657654
1414	Phosphorylation	GTSLSSESILSLEGS CCCCCCCCEEEECCC	30.67	25954137
1417	Phosphorylation	LSSESILSLEGSSST CCCCCEEEECCCCCC	23.78	25954137
1422	Phosphorylation	ILSLEGSSSTAGGSK EEEECCCCCCCCCCC	42.43	22468782
1423	Phosphorylation	LSLEGSSSTAGGSKR EEECCCCCCCCCCCE	24.79	22468782
1424	Phosphorylation	SLEGSSSTAGGSKRV EECCCCCCCCCCCEE	31.13	25954137
1428	Phosphorylation	SSSTAGGSKRVLSPA CCCCCCCCCEEECCC	19.17	22468782
1433	Phosphorylation	GGSKRVLSPAGSLEL CCCCEEECCCCCEEE	15.17	29255136
1437	Phosphorylation	RVLSPAGSLELTMET EEECCCCCEEEEHHH	22.30	29255136
1456	Phosphorylation	RVKEEEASKADEKLE HHHHHHHHHHHHHHH	31.49	-
1501	Phosphorylation	RELEMLSSLSSDPSD HHHHHHHHCCCCCCC	28.45	28348404
1503	Phosphorylation	LEMLSSLSSDPSDTK HHHHHHCCCCCCCCC	34.34	28348404
1504	Phosphorylation	EMLSSLSSDPSDTKE HHHHHCCCCCCCCCC	59.85	28348404
1547	Phosphorylation	KPHRRGLTPLSVKKE CCCCCCCCCCCCCCC	25.63	-
1550	Phosphorylation	RRGLTPLSVKKEDSK CCCCCCCCCCCCCCC	32.85	-
1658	Phosphorylation	LRSKQKVSKETYTMA HHHCCCCCCCEEEEC	31.63	24719451
1661	Phosphorylation	KQKVSKETYTMATAP CCCCCCCEEEECCCC	28.20	24719451
1692	Phosphorylation	MTEVHLPSLVSPEGQ CEEEECCCCCCCCCH	48.00	24719451
1695	Phosphorylation	VHLPSLVSPEGQKDL EECCCCCCCCCHHHH	23.64	24961811
1737	Phosphorylation	IKIFEGGYKSNEEYV EEEEECCCCCCCEEE	23.31	18083107
1739	Phosphorylation	IFEGGYKSNEEYVYV EEECCCCCCCEEEEE	40.78	21815630
1743	Phosphorylation	GYKSNEEYVYVRGRG CCCCCCEEEEECCCC	7.30	28796482
1745	Phosphorylation	KSNEEYVYVRGRGRG CCCCEEEEECCCCCC	5.41	28796482
1767	Phosphorylation	GIRCKKPSMLKKHIR CCCCCCHHHHHHHHH	45.70	22210691
1775	Phosphorylation	MLKKHIRTHTDVRPY HHHHHHHHCCCCHHH	28.64	-
1777	Phosphorylation	KKHIRTHTDVRPYVC HHHHHHCCCCHHHHH	35.26	-
1894	Phosphorylation	PHALRADSSPILGPQ CCCCCCCCCCCCCCC	36.71	30624053
1895	Phosphorylation	HALRADSSPILGPQP CCCCCCCCCCCCCCC	19.26	30108239
1927	Phosphorylation	EAERLTASSCSMSSQ HHHHHHHHHCCCCCC	27.00	22210691
1954	Phosphorylation	LGSVEKDTGSALSYK CCCCCCCCCCCCCCC	44.07	23312004
1956	Phosphorylation	SVEKDTGSALSYKPV CCCCCCCCCCCCCCC	28.29	22210691
1959	Phosphorylation	KDTGSALSYKPVSPR CCCCCCCCCCCCCCC	30.72	30266825
1960	Phosphorylation	DTGSALSYKPVSPRR CCCCCCCCCCCCCCC	21.84	30266825
1964	Phosphorylation	ALSYKPVSPRRPWSP CCCCCCCCCCCCCCC	22.63	25849741
1970	Phosphorylation	VSPRRPWSPSKEAGS CCCCCCCCCCCCCCC	23.21	24719451
1986	Phosphorylation	PPLARKHSLTKNDSS CCCHHHCCCCCCCCC	40.55	-
2006	Phosphorylation	PAREPQASAPSPPGL CCCCCCCCCCCCCCC	35.15	29255136
2009	Phosphorylation	EPQASAPSPPGLHVD CCCCCCCCCCCCCCC	43.36	29255136
2028	Phosphorylation	MGALPCGSPRLQLSP CCCCCCCCCCCCCCC	17.35	33259812
2034	Phosphorylation	GSPRLQLSPLTLCPL CCCCCCCCCCCCCCC	12.61	30108239
2037	Phosphorylation	RLQLSPLTLCPLGRE CCCCCCCCCCCCCCH	29.69	30108239
2053	Phosphorylation	APRAHVLSKLEGTTD HHCHHHHHHCCCCCC	33.82	27174698
2058	Phosphorylation	VLSKLEGTTDPGLPR HHHHCCCCCCCCCCC	20.74	27174698
2059	Phosphorylation	LSKLEGTTDPGLPRY HHHCCCCCCCCCCCC	51.56	27174698
2066	Phosphorylation	TDPGLPRYSPTRRWS CCCCCCCCCCCCCCC	19.64	27174698
2067	Phosphorylation	DPGLPRYSPTRRWSP CCCCCCCCCCCCCCC	22.52	27174698
2069	Phosphorylation	GLPRYSPTRRWSPGQ CCCCCCCCCCCCCCC	27.25	27174698
2073	Phosphorylation	YSPTRRWSPGQAESP CCCCCCCCCCCCCCC	19.83	30108239
2079	Phosphorylation	WSPGQAESPPRSAPP CCCCCCCCCCCCCCC	43.13	30108239
2125	Phosphorylation	PLPHKLLSRSPETCA CCCHHHHCCCCCCCC	40.94	28450419
2127	Phosphorylation	PHKLLSRSPETCASP CHHHHCCCCCCCCCH	24.58	28450419
2130	Phosphorylation	LLSRSPETCASPWQK HHCCCCCCCCCHHHH	19.43	28450419
2133	Phosphorylation	RSPETCASPWQKAES CCCCCCCCHHHHHHC	28.90	21712546
2142	Phosphorylation	WQKAESRSPSCSPGP HHHHHCCCCCCCCCC	30.37	27732954
2144	Phosphorylation	KAESRSPSCSPGPAH HHHCCCCCCCCCCCC	28.59	27732954
2146	Phosphorylation	ESRSPSCSPGPAHPL HCCCCCCCCCCCCCC	36.91	27732954
2245	Phosphorylation	AQERGRWSPTESSSA HHHHCCCCCCCCCCC	22.15	23927012
2247	Phosphorylation	ERGRWSPTESSSASV HHCCCCCCCCCCCCC	42.88	30108239
2249	Phosphorylation	GRWSPTESSSASVSP CCCCCCCCCCCCCCC	31.88	30108239
2250	Phosphorylation	RWSPTESSSASVSPV CCCCCCCCCCCCCCC	24.56	28450419
2251	Phosphorylation	WSPTESSSASVSPVA CCCCCCCCCCCCCCE	33.57	28450419
2253	Phosphorylation	PTESSSASVSPVAKV CCCCCCCCCCCCEEE	25.69	30108239
2255	Phosphorylation	ESSSASVSPVAKVSK CCCCCCCCCCEEEEE	15.91	23927012
2281	Phosphorylation	YPKERERTGGGPGRP CCCHHHCCCCCCCCC	35.11	25002506
2292	Phosphorylation	PGRPPDWTPHGTGAP CCCCCCCCCCCCCCC	16.88	25002506
2296	Phosphorylation	PDWTPHGTGAPAEPT CCCCCCCCCCCCCCC	27.43	25002506
2303	Phosphorylation	TGAPAEPTPTHSPCT CCCCCCCCCCCCCCC	32.12	25002506
2305	Phosphorylation	APAEPTPTHSPCTPP CCCCCCCCCCCCCCC	37.15	25002506
2307	Phosphorylation	AEPTPTHSPCTPPDT CCCCCCCCCCCCCCC	24.93	25002506
2310	Phosphorylation	TPTHSPCTPPDTLPR CCCCCCCCCCCCCCC	41.04	25002506
2314	Phosphorylation	SPCTPPDTLPRPPQG CCCCCCCCCCCCCCC	44.42	25002506
2327	Phosphorylation	QGRRAAQSWSPRLES CCCHHHHCCCCCCCC	25.46	27732954
2329	Phosphorylation	RRAAQSWSPRLESPR CHHHHCCCCCCCCCC	12.85	24719451
2331	Methylation	AAQSWSPRLESPRAP HHHCCCCCCCCCCCC	45.64	115478727
2346	Phosphorylation	TNPEPSATPPLDRSS CCCCCCCCCCCCCCC	29.76	-
2352	Phosphorylation	ATPPLDRSSSVGCLA CCCCCCCCCCCCHHH	26.99	23401153
2353	Phosphorylation	TPPLDRSSSVGCLAE CCCCCCCCCCCHHHH	29.91	28450419
2354	Phosphorylation	PPLDRSSSVGCLAEA CCCCCCCCCCHHHHH	24.63	28450419
2362	Phosphorylation	VGCLAEASARFPART CCHHHHHHHCCCCCC	16.10	27486199
2373	Phosphorylation	PARTRNLSGEPRTRQ CCCCCCCCCCCCCCC	44.66	24719451
2378	Phosphorylation	NLSGEPRTRQDSPKP CCCCCCCCCCCCCCC	43.32	27794612
2382	Phosphorylation	EPRTRQDSPKPSGSG CCCCCCCCCCCCCCC	26.87	27794612
2386	Phosphorylation	RQDSPKPSGSGEPRA CCCCCCCCCCCCCCC	52.28	27794612
2388	Phosphorylation	DSPKPSGSGEPRAHP CCCCCCCCCCCCCCC	44.30	27794612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZEP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZEP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZEP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF1_HUMAN	TRAF1	physical	11804591
TRAF2_HUMAN	TRAF2	physical	11804591
WWP1_HUMAN	WWP1	physical	16728642

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2037, AND MASSSPECTROMETRY.
PubMed: 17081983