CE112_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CE112_HUMAN
• UniProt AC: Q8N8E3
• Protein Name: Centrosomal protein of 112 kDa
• Gene Name: CEP112
• Organism: Homo sapiens (Human).
• Sequence Length: 955
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes around spindle poles in some cells.
• Protein Sequence: MEVGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRTERQRCALWIRKLCEPSGTGAGIMGRKNRNLYAKLLLHMLKRGALEGPFTHRPEPGTLKILPSYMSIYFDEPNPARAKGSSPEGLPAWVLGELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	IRKLCEPSGTGAGIM HHHHCCCCCCCCCCC	27.05	29038488
114	Phosphorylation	NPARAKGSSPEGLPA CCCCCCCCCCCCCCH	41.85	27251275
115	Phosphorylation	PARAKGSSPEGLPAW CCCCCCCCCCCCCHH	35.32	25627689
139	Ubiquitination	HKLNESWKLSSGEDN CCCCCCCCCCCCCCC	48.01	-
141	Phosphorylation	LNESWKLSSGEDNTL CCCCCCCCCCCCCCC	32.35	30624053
142	Phosphorylation	NESWKLSSGEDNTLV CCCCCCCCCCCCCCC	57.55	30624053
147	Phosphorylation	LSSGEDNTLVQSPTD CCCCCCCCCCCCCCC	40.40	30624053
151	Phosphorylation	EDNTLVQSPTDVYSR CCCCCCCCCCCCCCC	23.45	28857561
153	Phosphorylation	NTLVQSPTDVYSREQ CCCCCCCCCCCCCHH	43.26	28857561
157	Phosphorylation	QSPTDVYSREQYTGK CCCCCCCCCHHHCCC	29.23	29523821
169	Phosphorylation	TGKLRVRSHSLSPTH CCCEEEECCCCCCCC	17.99	28176443
171	Phosphorylation	KLRVRSHSLSPTHRE CEEEECCCCCCCCCC	31.61	28176443
173	Phosphorylation	RVRSHSLSPTHREDG EEECCCCCCCCCCCC	30.66	28176443
175	Phosphorylation	RSHSLSPTHREDGQN ECCCCCCCCCCCCCC	30.14	23663014
184	Phosphorylation	REDGQNITPKICEVY CCCCCCCCHHHHHHH	26.53	23403867
191	Phosphorylation	TPKICEVYSKKSPVS CHHHHHHHCCCCCCC	7.77	29496907
192	Phosphorylation	PKICEVYSKKSPVSL HHHHHHHCCCCCCCC	38.49	29214152
194	Ubiquitination	ICEVYSKKSPVSLDD HHHHHCCCCCCCCCH	54.79	-
195	Phosphorylation	CEVYSKKSPVSLDDS HHHHCCCCCCCCCHH	33.98	23403867
198	Phosphorylation	YSKKSPVSLDDSDIE HCCCCCCCCCHHHHH	29.48	23403867
202	Phosphorylation	SPVSLDDSDIEARLN CCCCCCHHHHHHHHH	39.91	23403867
210	Phosphorylation	DIEARLNSWNLGIEN HHHHHHHHCCCCCCC	23.18	28857561
236	Phosphorylation	SLMTPKFSLRKSSSF CCCCCCCCCCCCCCC	33.13	25394399
240	Phosphorylation	PKFSLRKSSSFHDDH CCCCCCCCCCCCCHH	25.44	23927012
241	Phosphorylation	KFSLRKSSSFHDDHF CCCCCCCCCCCCHHH	39.81	23927012
242	Phosphorylation	FSLRKSSSFHDDHFL CCCCCCCCCCCHHHH	33.42	23927012
250	Phosphorylation	FHDDHFLSRIREKEL CCCHHHHHHHHHHHC	25.39	23403867
303	Phosphorylation	ELKTLYRSKQHETEE HHHHHHHHCCCCHHH	24.10	29083192
308	Phosphorylation	YRSKQHETEETIRKL HHHCCCCHHHHHHHH	36.68	29083192
311	Phosphorylation	KQHETEETIRKLEKK CCCCHHHHHHHHHHH	21.61	29083192
333	Acetylation	CQVIRETKEDQIAEL CHHHHHCCHHHHHHH	55.32	7662525
342	Acetylation	DQIAELKKICEQSTE HHHHHHHHHHHHHHH	66.27	7662533
350	Phosphorylation	ICEQSTESLNNDWEK HHHHHHHHHCHHHHH	36.16	25106551
637	Phosphorylation	ADLTRSKSLREKQSK HHHHCCHHHHHHHHH	33.63	-
717	Methylation	NQIQEFKKRDAQVIA HHHHHHHHHCHHHHH	61.91	23644510
801	Phosphorylation	MTLEKANSKLKQIEK HHHHHHHHHHHHHHH	44.20	24719451
829	Phosphorylation	AELQTTISSLKEENS HHHHHHHHHHCHHCH	27.76	24719451
830	Phosphorylation	ELQTTISSLKEENSQ HHHHHHHHHCHHCHH	39.34	24719451
928	Phosphorylation	QELEDTISSLKSQVN HHHHHHHHHHHHHHH	31.54	24719451
929	Phosphorylation	ELEDTISSLKSQVNF HHHHHHHHHHHHHHH	35.65	24719451
942	Phosphorylation	NFLQKRASILQEELT HHHHHHHHHHHHHHH	28.06	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CE112_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CE112_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CE112_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CE112_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.