| UniProt ID | MFGM_HUMAN | |
|---|---|---|
| UniProt AC | Q08431 | |
| Protein Name | Lactadherin | |
| Gene Name | MFGE8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 387 | |
| Subcellular Localization |
Membrane Peripheral membrane protein . Secreted . |
|
| Protein Description | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.; Medin is the main constituent of aortic medial amyloid.. | |
| Protein Sequence | MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 42 | Phosphorylation | GGLCEEISQEVRGDV CCHHHHHHHHHCCCC | 24.46 | 24670416 | |
| 59 | Ubiquitination | SYTCTCLKGYAGNHC CCCEEEEECCCCCCC | 52.61 | - | |
| 69 | Ubiquitination | AGNHCETKCVEPLGM CCCCCCCEEEEECCC | 17.62 | - | |
| 84 | Phosphorylation | ENGNIANSQIAASSV CCCCCCCHHHHHHHE | 17.59 | 28450419 | |
| 89 | Phosphorylation | ANSQIAASSVRVTFL CCHHHHHHHEEEEEE | 21.97 | 22468782 | |
| 90 | Phosphorylation | NSQIAASSVRVTFLG CHHHHHHHEEEEEEC | 14.82 | 28450419 | |
| 94 | Phosphorylation | AASSVRVTFLGLQHW HHHHEEEEEECCHHH | 11.54 | 22468782 | |
| 112 | Ubiquitination | LARLNRAGMVNAWTP HHHCCCCCCEEEECC | 19.82 | - | |
| 133 | Ubiquitination | PWIQVNLLRRMWVTG CCHHHHHHHHHHHHH | 2.48 | - | |
| 156 | Ubiquitination | LASHEYLKAFKVAYS HHCHHHHHHHEEEHH | 51.37 | 21890473 | |
| 156 | Ubiquitination | LASHEYLKAFKVAYS HHCHHHHHHHEEEHH | 51.37 | 21890473 | |
| 156 | Ubiquitination | LASHEYLKAFKVAYS HHCHHHHHHHEEEHH | 51.37 | 21890473 | |
| 177 | Ubiquitination | DFIHDVNKKHKEFVG EEEEECCHHHHHHHC | 56.98 | - | |
| 228 | N-linked_Glycosylation | ELLGCELNGCANPLG HHHCCEECCCCCCCC | 22.62 | 18780401 | |
| 238 | N-linked_Glycosylation | ANPLGLKNNSIPDKQ CCCCCCCCCCCCCCE | 53.15 | 18780401 | |
| 247 | Phosphorylation | SIPDKQITASSSYKT CCCCCEEECCCCCCE | 20.28 | 20166139 | |
| 249 | Phosphorylation | PDKQITASSSYKTWG CCCEEECCCCCCEEE | 15.92 | 20166139 | |
| 250 | Phosphorylation | DKQITASSSYKTWGL CCEEECCCCCCEEEE | 34.91 | 20166139 | |
| 252 | Phosphorylation | QITASSSYKTWGLHL EEECCCCCCEEEEEE | 17.87 | 20166139 | |
| 261 | Phosphorylation | TWGLHLFSWNPSYAR EEEEEEEEECHHHEE | 32.10 | 26091039 | |
| 265 | Phosphorylation | HLFSWNPSYARLDKQ EEEEECHHHEEECCC | 28.36 | 26091039 | |
| 266 | Phosphorylation | LFSWNPSYARLDKQG EEEECHHHEEECCCC | 9.30 | 26091039 | |
| 325 | N-linked_Glycosylation | SYKVAYSNDSANWTE EEEEEECCCCCCCCE | 34.28 | 18780401 | |
| 329 | N-linked_Glycosylation | AYSNDSANWTEYQDP EECCCCCCCCEECCC | 50.59 | 18780401 | |
| 350 | N-linked_Glycosylation | IFPGNWDNHSHKKNL CCCCCCCCCCCCCCC | 30.12 | 18780401 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 42 | S | Phosphorylation | Kinase | FAM20C | Q8IXL6 | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MFGM_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MFGM_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YTHD1_HUMAN | YTHDF1 | physical | 26186194 | |
| ITB5_HUMAN | ITGB5 | physical | 26186194 | |
| ITB5_HUMAN | ITGB5 | physical | 28514442 | |
| YTHD1_HUMAN | YTHDF1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Identification of N-linked glycoproteins in human milk by hydrophilicinteraction liquid chromatography and mass spectrometry."; Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.; Proteomics 8:3833-3847(2008). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-228; ASN-238; ASN-325;ASN-329 AND ASN-350, AND MASS SPECTROMETRY. | |
