GEN_HUMAN - dbPTM
GEN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GEN_HUMAN
UniProt AC Q17RS7
Protein Name Flap endonuclease GEN homolog 1
Gene Name GEN1
Organism Homo sapiens (Human).
Sequence Length 908
Subcellular Localization Nucleus .
Protein Description Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. [PubMed: 19020614]
Protein Sequence MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKPHLRNLFFRISYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQKTGRSHFKSVLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRWNETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRIKPKENNLPEPDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNAQEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPAIQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHLLSGITDLCLQDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLSKDLPGIPLQNESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRKVDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKLSSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQRLKLRFQST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14UbiquitinationWQILEPVKQHIPLRN
HHHHHHHHHHCCCCC		47.04-
43AcetylationCEAQTVKKMMGSVMK
HHHHHHHHHHCHHCH		29.778258263
47PhosphorylationTVKKMMGSVMKPHLR
HHHHHHCHHCHHHHH		10.9224275569
88UbiquitinationLKADVISKRNQSRYG
CCEEHHCCCCHHHCC		44.2229967540
99UbiquitinationSRYGSSGKSWSQKTG
HHCCCCCCCHHHHHC		51.1827667366
104UbiquitinationSGKSWSQKTGRSHFK
CCCCHHHHHCHHHHH		47.6429967540
111UbiquitinationKTGRSHFKSVLRECL
HHCHHHHHHHHHHHH		33.94-
175UbiquitinationRNFTMNTKDPHVDCY
CCCCCCCCCCCCEEE		65.34-
188UbiquitinationCYTMSSIKSKLGLDR
EEEHHHHHHHHCCCH		43.4129967540
190UbiquitinationTMSSIKSKLGLDRDA
EHHHHHHHHCCCHHH		41.3929967540
219UbiquitinationKGVPGVGKEQALKLI
CCCCCCCHHHHHHHH		44.2227667366
224UbiquitinationVGKEQALKLIQILKG
CCHHHHHHHHHHHCC		46.7029967540
230AcetylationLKLIQILKGQSLLQR
HHHHHHHCCHHHHHH		57.4420167786
230UbiquitinationLKLIQILKGQSLLQR
HHHHHHHCCHHHHHH		57.4421890473
244PhosphorylationRFNRWNETSCNSSPQ
HHHHCCCCCCCCCCC		35.0525850435
245PhosphorylationFNRWNETSCNSSPQL
HHHCCCCCCCCCCCE		12.7225850435
248PhosphorylationWNETSCNSSPQLLVT
CCCCCCCCCCCEEEE		47.9625850435
249PhosphorylationNETSCNSSPQLLVTK
CCCCCCCCCCEEEEE		11.5925850435
256UbiquitinationSPQLLVTKKLAHCSV
CCCEEEEEECCCCCC		38.01-
257UbiquitinationPQLLVTKKLAHCSVC
CCEEEEEECCCCCCC		41.3529967540
262PhosphorylationTKKLAHCSVCSHPGS
EEECCCCCCCCCCCC		19.1123927012
265PhosphorylationLAHCSVCSHPGSPKD
CCCCCCCCCCCCCCC		30.4823927012
269PhosphorylationSVCSHPGSPKDHERN
CCCCCCCCCCCCCCC		32.9730576142
292PhosphorylationKYCEPHDYEYCCPCE
CCCCCCCCCCCCCCH		13.0322817900
294PhosphorylationCEPHDYEYCCPCEWH
CCCCCCCCCCCCHHH		7.9822817900
348PhosphorylationKLVKVIRYQRPDLLL
HHHHEEECCCCCEEE		9.5729496907
370PhosphorylationKMEWPNHYACEKLLV
HCCCCCHHHHHHHHH		21.4223663014
380PhosphorylationEKLLVLLTHYDMIER
HHHHHHHHHHHHHHH		17.7723663014
382PhosphorylationLLVLLTHYDMIERKL
HHHHHHHHHHHHHHH		11.2823663014
438PhosphorylationHGEFALLTIEEESLF
CCEEEEEEECHHHHH		27.48-
509PhosphorylationKQNSKLNSGISPDPT
HCCCCCCCCCCCCCC		48.1922199227
512PhosphorylationSKLNSGISPDPTLPQ
CCCCCCCCCCCCCCH		27.1222199227
516PhosphorylationSGISPDPTLPQESIS
CCCCCCCCCCHHHHH		59.4522199227
521PhosphorylationDPTLPQESISASLNS
CCCCCHHHHHHHHHH		19.3222199227
523PhosphorylationTLPQESISASLNSLL
CCCHHHHHHHHHHHH		22.5327251275
525PhosphorylationPQESISASLNSLLLP
CHHHHHHHHHHHHCC		22.6927251275
528PhosphorylationSISASLNSLLLPKNT
HHHHHHHHHHCCCCC		26.2027251275
557UbiquitinationPLAIQQIKAVSKSLI
HHHHHHHHHHHHHHH		38.1029967540
611UbiquitinationNTFSHDLKSEVESEL
CCCCCCHHHHHHHHH		51.10-
644UbiquitinationERYTANIKKVLDEDS
CEEEHHHHHHHCCCC		36.3127667366
645UbiquitinationRYTANIKKVLDEDSD
EEEHHHHHHHCCCCC		44.2129967540
675UbiquitinationCLQDLPLKERIFTKL
HHCCCCCCHHHHHHC		42.9029967540
680PhosphorylationPLKERIFTKLSYPQD
CCCHHHHHHCCCCCC		28.8029978859
681UbiquitinationLKERIFTKLSYPQDN
CCHHHHHHCCCCCCC		25.3729967540
683PhosphorylationERIFTKLSYPQDNLQ
HHHHHHCCCCCCCCC		36.0029978859
696UbiquitinationLQPDVNLKTLSILSV
CCCCCCCCEEEEEEE		42.06-
697PhosphorylationQPDVNLKTLSILSVK
CCCCCCCEEEEEEEH		28.98-
702PhosphorylationLKTLSILSVKESCIA
CCEEEEEEEHHHHHC		29.4924719451
704UbiquitinationTLSILSVKESCIANS
EEEEEEEHHHHHCCC		40.3029967540
717PhosphorylationNSGSDCTSHLSKDLP
CCCCCHHHHHCCCCC		28.85-
721UbiquitinationDCTSHLSKDLPGIPL
CHHHHHCCCCCCCCC		70.42-
739UbiquitinationSRDSKILKGDQLLQE
CCCCCCCCHHHHHHC		65.0129967540
749UbiquitinationQLLQEDYKVNTSVPY
HHHHCCCCCCCCCCC		41.1329967540
764UbiquitinationSVSNTVVKTCNVRPP
CCCCEEEEECCCCCC		42.9229967540
765PhosphorylationVSNTVVKTCNVRPPN
CCCEEEEECCCCCCC		9.5626074081
773PhosphorylationCNVRPPNTALDHSRK
CCCCCCCCCCCCCCC		34.0826074081
778PhosphorylationPNTALDHSRKVDMQT
CCCCCCCCCCCCHHH		33.2026074081
780UbiquitinationTALDHSRKVDMQTTR
CCCCCCCCCCHHHHH		45.6729967540
785PhosphorylationSRKVDMQTTRKILMK
CCCCCHHHHHHHHHH		23.1826074081
786PhosphorylationRKVDMQTTRKILMKK
CCCCHHHHHHHHHHH		17.0526074081
794PhosphorylationRKILMKKSVCLDRHS
HHHHHHHCHHCCCCC		16.7329978859
794O-linked_GlycosylationRKILMKKSVCLDRHS
HHHHHHHCHHCCCCC		16.7330379171
801PhosphorylationSVCLDRHSSDEQSAP
CHHCCCCCCCCCCCC		40.1430576142
802PhosphorylationVCLDRHSSDEQSAPV
HHCCCCCCCCCCCCC		38.7629978859
806PhosphorylationRHSSDEQSAPVFGKA
CCCCCCCCCCCCCCC		32.2829978859
812UbiquitinationQSAPVFGKAKYTTQR
CCCCCCCCCHHHHHH		30.1829967540
814UbiquitinationAPVFGKAKYTTQRMK
CCCCCCCHHHHHHCH		46.76-
817PhosphorylationFGKAKYTTQRMKHSS
CCCCHHHHHHCHHHH		15.8724719451
841PhosphorylationESGHNKLSSPKIHIK
HCCCCCCCCCCEEEE		46.3223312004
842PhosphorylationSGHNKLSSPKIHIKE
CCCCCCCCCCEEEEH		40.4223312004
856PhosphorylationETEQCVRSYETAENE
HHHHHHHHHHHHCCC		13.6129978859
857PhosphorylationTEQCVRSYETAENEE
HHHHHHHHHHHCCCC		13.5129978859
872UbiquitinationSCFPDSTKSSLSSLQ
CCCCCCCHHHHHHCC		41.8429967540
882UbiquitinationLSSLQCHKKENNSGT
HHHCCCCCCCCCCCC		70.2129967540
887PhosphorylationCHKKENNSGTCLDSP
CCCCCCCCCCCCCCC		47.2427794612
889PhosphorylationKKENNSGTCLDSPLP
CCCCCCCCCCCCCCC		15.0927794612
893PhosphorylationNSGTCLDSPLPLRQR
CCCCCCCCCCCHHHH		18.5229255136
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseDCAF11Q8TEB1
PMID:31409866
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GEN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GEN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GEN_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GEN_HUMAN

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Related Literatures of Post-Translational Modification

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