S22AB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S22AB_HUMAN
• UniProt AC: Q9NSA0
• Protein Name: Solute carrier family 22 member 11
• Gene Name: SLC22A11
• Organism: Homo sapiens (Human).
• Sequence Length: 550
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds..
• Protein Sequence: MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	N-linked_Glycosylation	PSQMLLENFSAAIPG CHHHHHHHHHHHCCC	35.82	UniProtKB CARBOHYD
56	N-linked_Glycosylation	CWTHMLDNGSAVSTN CEEECCCCCCCCCCC	42.21	UniProtKB CARBOHYD
65	Phosphorylation	SAVSTNMTPKALLTI CCCCCCCCCCEEEEE	24.57	-
99	N-linked_Glycosylation	QWQLLDPNATATSWS CCEECCCCCCCCCCC	49.98	UniProtKB CARBOHYD
174	Phosphorylation	FGRKPMLSWCCLQLA HCCCHHHHHHHHHHH	16.30	27732954
185	Phosphorylation	LQLAVAGTSTIFAPT HHHHHHCCCCCCCCH	16.98	27732954
186	Phosphorylation	QLAVAGTSTIFAPTF HHHHHCCCCCCCCHH	20.70	27732954
187	Phosphorylation	LAVAGTSTIFAPTFV HHHHCCCCCCCCHHH	21.69	27732954
192	Phosphorylation	TSTIFAPTFVIYCGL CCCCCCCHHHHHHCH	27.40	27732954
196	Phosphorylation	FAPTFVIYCGLRFVA CCCHHHHHHCHHHHH	3.83	27732954
318	Phosphorylation	LTIEVLMSSVKEEVA CHHHHHHHHHHHHHH	28.02	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S22AB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S22AB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S22AB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NED4L_HUMAN	NEDD4L	physical	26740304

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.