GIMA8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIMA8_HUMAN
• UniProt AC: Q8ND71
• Protein Name: GTPase IMAP family member 8
• Gene Name: GIMAP8
• Organism: Homo sapiens (Human).
• Sequence Length: 665
• Subcellular Localization: Endoplasmic reticulum. Golgi apparatus. Mitochondrion. Cytoplasm, cytosol .
• Protein Description: Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections..
• Protein Sequence: MSEQSCQMSELRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELSAPSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEKNKPLKQLVQDYEGRYCIFNNKTNSKDEQITQVLELLRKVESLVNTNGGPYHVNFKTEGSRFQDCVNEAASQEGDKPQGPRERQLQSTGPEQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHICTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFNYRATGEEEQRQADELLEKIESMVHQNGNKHCVFREKETLNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSFNQMLDVEKDPSRLEEEVKRCLSCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDNKALRRIFKKCGRRVCAFNNKETGQAQETQVKALLTKVNDLRKESGWSGYPHTQENVSKLIKNVQEMSQAEKLLKNLIGILQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEQSCQMS ------CCHHHHHHH	44.32	28857561
9	Phosphorylation	SEQSCQMSELRLLLL CHHHHHHHHHHHHHH	13.96	30631047
44	Phosphorylation	KSKFSDQTVIKMCQR HCCCCCHHHHHHHHC	29.23	22617229
53	Phosphorylation	IKMCQRESWVLRERK HHHHHCCCHHHCCCE	25.36	28857561
71	Phosphorylation	IDTPDLFSSIACAED ECCCHHHHHCCCHHH	28.29	-
150	Ubiquitination	LLQDFIEKNKPLKQL HHHHHHHHCCCHHHH	66.51	-
220	Phosphorylation	DCVNEAASQEGDKPQ HHHHHHHHHCCCCCC	35.49	23401153
266	Phosphorylation	GKSAAGNSILGRQAF CCCCCCCCHHCHHHH	20.48	-
299	Phosphorylation	SWRKKKVSIIDAPDI HHHCCCEEEEECCCH	23.78	28857561
307	Phosphorylation	IIDAPDISSLKNIDS EEECCCHHHHCCCCH	36.68	24719451
421	Phosphorylation	ELLEKIESMVHQNGN HHHHHHHHHHHHCCC	29.58	28509920
452	Phosphorylation	GRSGTGKSATGNSIL ECCCCCCCCCCCHHH	32.20	27307780
454	Phosphorylation	SGTGKSATGNSILGS CCCCCCCCCCHHHHH	43.94	27307780
457	Phosphorylation	GKSATGNSILGSLVF CCCCCCCHHHHHHHH	22.12	27307780
461	Phosphorylation	TGNSILGSLVFTSRL CCCHHHHHHHHCCCC	20.22	27307780
465	Phosphorylation	ILGSLVFTSRLRAQP HHHHHHHCCCCEEEC	12.88	27307780
466	Phosphorylation	LGSLVFTSRLRAQPV HHHHHHCCCCEEECC	20.18	27307780
557	Phosphorylation	AIFGADFTKYAIMLF HHHCCCHHHHHHHHE	24.56	25849741
628	Phosphorylation	VNDLRKESGWSGYPH HHHHHHHHCCCCCCC	48.90	22210691
631	Phosphorylation	LRKESGWSGYPHTQE HHHHHCCCCCCCCHH	31.79	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GIMA8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIMA8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIMA8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
OAS2_HUMAN	OAS2	physical	28514442
SRP68_HUMAN	SRP68	physical	28514442
SRP54_HUMAN	SRP54	physical	28514442
RPC5_HUMAN	POLR3E	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.