C2TA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2TA_HUMAN
• UniProt AC: P33076
• Protein Name: MHC class II transactivator
• Gene Name: CIITA
• Organism: Homo sapiens (Human).
• Sequence Length: 1130
• Subcellular Localization: Nucleus . Nucleus, PML body . Recruited to PML body by PML.
• Protein Description: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro)..
• Protein Sequence: MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFKHIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVRPVSDCSTLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	Phosphorylation	DEETREAYANIAELD CHHHHHHHHHHHHHH	8.74	22210691
104	Phosphorylation	NIAELDQYVFQDSQL HHHHHHHHHHCCHHH	11.69	22210691
109	Phosphorylation	DQYVFQDSQLEGLSK HHHHHCCHHHCCCCH	26.36	22210691
141	Acetylation	MPAEVGQKSQKRPFP CCHHHCCCCCCCCCC	49.26	11046145
144	Acetylation	EVGQKSQKRPFPEEL HHCCCCCCCCCCCCC	69.95	11514574
280	Phosphorylation	TVHGLPTSPDRPGST EEECCCCCCCCCCCC	23.90	20538595
286	Phosphorylation	TSPDRPGSTSPFAPS CCCCCCCCCCCCCCC	28.52	15210796
287	Phosphorylation	SPDRPGSTSPFAPSA CCCCCCCCCCCCCCC	46.46	29449344
288	Phosphorylation	PDRPGSTSPFAPSAT CCCCCCCCCCCCCCC	21.51	23663014
293	Phosphorylation	STSPFAPSATDLPSM CCCCCCCCCCCCCCC	40.13	15210796
315	Ubiquitination	RANMTEHKTSPTQCP CCCCCCCCCCCCCCC	44.45	20538595
330	Ubiquitination	AAGEVSNKLPKWPEP CCHHHCCCCCCCCCH	59.67	20538595
333	Ubiquitination	EVSNKLPKWPEPVEQ HHCCCCCCCCCHHHH	82.74	2053859
373	Phosphorylation	VQARLERSSSKSLER HHHHHHHCCCHHHHH	29.59	17991736
427	Phosphorylation	GKAGQGKSYWAGAVS ECCCCCHHHHHHHHH	32.50	-
428	Phosphorylation	KAGQGKSYWAGAVSR CCCCCHHHHHHHHHH	11.63	-
434	Phosphorylation	SYWAGAVSRAWACGR HHHHHHHHHHHHCCC	18.75	-
536	Ubiquitination	LAGLFQKKLLRGCTL HHHHHHHHHHCCCEE	41.81	-
546	Phosphorylation	RGCTLLLTARPRGRL CCCEEEEEECCCCHH	22.16	-
740	Phosphorylation	LPQYLALTPRKKRPY CCHHHHCCCCCCCCC	18.55	24719451
834	Phosphorylation	QELPGRLSFLGTRLT HHCCCCCEECCCCCC	19.64	21712546
838	Phosphorylation	GRLSFLGTRLTPPDA CCCEECCCCCCCCCH	25.34	21712546
916	O-linked_Glycosylation	QAAEEKFTIEPFKAK HHHHHCCCCCCCCCC	35.18	30379171
942	Phosphorylation	VQTQRTRSSSEDTAG HHHHHHCCCCCCCCC	37.29	25002506
943	Phosphorylation	QTQRTRSSSEDTAGE HHHHHCCCCCCCCCC	34.16	25002506
944	Phosphorylation	TQRTRSSSEDTAGEL HHHHCCCCCCCCCCC	40.51	26670566
947	Phosphorylation	TRSSSEDTAGELPAV HCCCCCCCCCCCCCH	32.29	25002506
959	Acetylation	PAVRDLKKLEFALGP CCHHHHHHCCHHCCC	61.62	156323
1016	Phosphorylation	ATFPQLKSLETLNLS CCCHHHCCCCCCCCC	39.78	29083192
1019	Phosphorylation	PQLKSLETLNLSQNN HHHCCCCCCCCCCCC	26.66	29083192
1023	Phosphorylation	SLETLNLSQNNITDL CCCCCCCCCCCCCHH	29.77	29116813
1028	Phosphorylation	NLSQNNITDLGAYKL CCCCCCCCHHHHHHH	27.56	29083192
1033	Phosphorylation	NITDLGAYKLAEALP CCCHHHHHHHHHHHH	12.53	29083192
1045	Phosphorylation	ALPSLAASLLRLSLY HHHHHHHHHHHHHHH	23.48	24719451
1050	Phosphorylation	AASLLRLSLYNNCIC HHHHHHHHHHCCCCC	23.52	11416140
1073	O-linked_Glycosylation	RVLPDMVSLRVMDVQ HHCCCCCEEEEEECC	12.10	30379171
1073	Phosphorylation	RVLPDMVSLRVMDVQ HHCCCCCEEEEEECC	12.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
280	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
280	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
288	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
288	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
373	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
834	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
834	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
834	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
1050	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1050	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1050	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
1128	S	Phosphorylation	Kinase	PRKACA	P17252	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF8	Q5T0T0	PMID:19566897
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF1	Q8TCQ1	PMID:19880452
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF5	Q9NX47	PMID:18389477

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2TA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2TA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA1_HUMAN	NCOA1	physical	12933903
RFX5_HUMAN	RFX5	physical	11003667
RFXK_HUMAN	RFXANK	physical	11003667
MK03_HUMAN	MAPK3	physical	18245089
MK01_HUMAN	MAPK1	physical	18245089
HDAC2_HUMAN	HDAC2	physical	19041327
SMCA4_HUMAN	SMARCA4	physical	12077331
HDAC4_HUMAN	HDAC4	physical	15964851
HDAC2_HUMAN	HDAC2	physical	17991736
SIN3B_HUMAN	SIN3B	physical	17991736
TF2B_HUMAN	GTF2B	physical	9177216
TAF9_HUMAN	TAF9	physical	9177216
PRS8_HUMAN	PSMC5	physical	18215421
PPARG_HUMAN	PPARG	physical	17611194
EP300_HUMAN	EP300	physical	26871568
EP400_HUMAN	EP400	physical	26871568
TBP_HUMAN	TBP	physical	26871568
RFX5_HUMAN	RFX5	physical	26871568
PRS8_HUMAN	PSMC5	physical	26871568
PML_HUMAN	PML	physical	28555140
CCNT1_HUMAN	CCNT1	physical	28555140

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 209920: Bare lymphocyte syndrome 2 (BLS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.