RGF1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGF1A_HUMAN
• UniProt AC: Q8N9B8
• Protein Name: Ras-GEF domain-containing family member 1A
• Gene Name: RASGEF1A
• Organism: Homo sapiens (Human).
• Sequence Length: 481
• Protein Description: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration..
• Protein Sequence: MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	YIFTFLLSSRVFMPP HEEHHHHHCCCCCCH	20.46	24719451
77	Phosphorylation	IFTFLLSSRVFMPPH EEHHHHHCCCCCCHH	32.22	24719451
112	Phosphorylation	PEKAKLKSFSAKIVQ CCHHHHHHHHHHHHH	34.56	30108239
114	Phosphorylation	KAKLKSFSAKIVQLL HHHHHHHHHHHHHHH	35.43	30108239
157	Phosphorylation	QCDEENGTVKKAIAQ HHHHCCCHHHHHHHH	40.51	23312004
333	Phosphorylation	ARLKKTWSKVKTAKF HHHHHHHHHHHHCCC	32.57	22617229
334	Acetylation	RLKKTWSKVKTAKFD HHHHHHHHHHHCCCC	39.03	19810219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGF1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGF1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGF1A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RGF1A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.