NMDE4_HUMAN - dbPTM
NMDE4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NMDE4_HUMAN
UniProt AC O15399
Protein Name Glutamate receptor ionotropic, NMDA 2D
Gene Name GRIN2D
Organism Homo sapiens (Human).
Sequence Length 1336
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein.
Protein Description Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). [PubMed: 9489750]
Protein Sequence MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationLLALACASPFPEEAP
HHHHHHCCCCCCCCC		27.2728258704
92N-linked_GlycosylationRPVALVLNGSDPRSL
CCEEEEECCCCHHHH		40.21UniProtKB CARBOHYD
108PhosphorylationLQLCDLLSGLRVHGV
HHHHHHHHCCCEEEE		42.9824719451
309PhosphorylationAGLFAVRSAGWRDDL
CCEEEHHCCCCHHHH		25.2422210691
352N-linked_GlycosylationGHDCRAQNRTHRGES
CCCCCCCCCCCCCCC		50.24UniProtKB CARBOHYD
366N-linked_GlycosylationSLHRYFMNITWDNRD
CHHHHEEECEECCCC		20.74UniProtKB CARBOHYD
384N-linked_GlycosylationNEDGFLVNPSLVVIS
CCCCCCCCCEEEEEE		23.69-
391PhosphorylationNPSLVVISLTRDRTW
CCEEEEEEEECCCCE		16.4524719451
393PhosphorylationSLVVISLTRDRTWEV
EEEEEEEECCCCEEE		24.5920068231
412UbiquitinationEQQTLRLKYPLWSRY
HHEEHHHCCCHHHHC		38.09-
467N-linked_GlycosylationVPCRSQLNRTHSPPP
CCCHHHCCCCCCCCC		38.89UniProtKB CARBOHYD
516UbiquitinationTNGKHGKKIDGVWNG
ECCCCCCEECCCEEC		51.0921906983
569N-linked_GlycosylationSVMVARSNGTVSPSA
EEEEEECCCCCCHHH		44.60UniProtKB CARBOHYD
581PhosphorylationPSAFLEPYSPAVWVM
HHHHCCCCCHHHHHH		20.22-
620UbiquitinationNRSLATGKRPGGSTF
CCCCCCCCCCCCCCE		51.5721890473
689PhosphorylationIQEEYVDTVSGLSDR
HCHHHHHHCCCCCCC		13.4122210691
691PhosphorylationEEYVDTVSGLSDRKF
HHHHHHCCCCCCCCC		35.7922210691
694PhosphorylationVDTVSGLSDRKFQRP
HHHCCCCCCCCCCCC		38.6022210691
697UbiquitinationVSGLSDRKFQRPQEQ
CCCCCCCCCCCCHHH		51.3321890473
715N-linked_GlycosylationLKFGTVPNGSTEKNI
CCCCCCCCCCCCCCH		53.35-
720UbiquitinationVPNGSTEKNIRSNYP
CCCCCCCCCHHHCCC		58.7321890473
732PhosphorylationNYPDMHSYMVRYNQP
CCCCHHHHHHHCCCH		5.73-
736PhosphorylationMHSYMVRYNQPRVEE
HHHHHHHCCCHHHHH		13.51-
749UbiquitinationEEALTQLKAGKLDAF
HHHHHHHHCCCCCEE		45.3221906983
758PhosphorylationGKLDAFIYDAAVLNY
CCCCEEEEHHHHHHH		7.9622817900
765PhosphorylationYDAAVLNYMARKDEG
EHHHHHHHHHHCCCC		6.49-
789PhosphorylationKVFATTGYGIALHKG
CEEEECCCCEEECCC		11.8520049867
795UbiquitinationGYGIALHKGSRWKRP
CCCEEECCCCCCCCC		60.4721890473
1054PhosphorylationRLAFEDESPPAPARW
EHHCCCCCCCCCCCC		48.8024076635
1157UbiquitinationGRYWSVDKLGGWRAG
CCCCEEEECCCCCCC		47.0421890473
1271PhosphorylationPPAPTSRSLEDLSSC
CCCCCCCCHHHHHCC		35.5627251275
1288PhosphorylationAAPARRLTGPSRHAR
CCCHHHCCCCCHHHH		45.2827273156
1316MethylationTASHRRHRGGDLGTR
CCCCCCCCCCCCCCC		49.32-
1326PhosphorylationDLGTRRGSAHFSSLE
CCCCCCCCCCHHHCC		19.43-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseNEDD4P46934
PMID:23639431
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NMDE4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NMDE4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DLGP2_RATDlgap2physical
7569905
NEDD4_HUMANNEDD4physical
23639431
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00711 Ketamine hydrochloride (JP16/USP); Ketalar (TN)
D00848 Dextromethorphan hydrobromide hydrate (JP16); Dextromethorphan hydrobromide (USP); Benylin DM (TN)
D01445 Ifenprodil tartrate (JP16); Cerocral (TN)
D02102 Methadone hydrochloride (JAN/USP); Dolophine hydrochloride (TN)
D02410 Selfotel (USAN/INN)
D02780 Acamprosate calcium (JAN/USAN); Campral (TN); Regtect (TN)
D02973 Aptiganel hydrochloride (USAN)
D03679 Delucemine hydrochloride (USAN)
D03742 Dextromethorphan (USP)
D03744 Dextromethorphan polistirex (USAN); Delsym (TN)
D03746 Dextrorphan hydrochloride (USAN)
D03878 Dizocilpine maleate (USAN)
D04226 Flupirtine maleate (USAN)
D04308 Gavestinel (USAN/INN)
D04728 Licostinel (USAN/INN)
D04905 Memantine hydrochloride (JAN/USAN); Namenda (TN); Memary (TN)
D05145 Neramexane mesylate (USAN)
D05447 Perzinfotel (USAN/INN)
D05453 Phencyclidine hydrochloride (USAN); PCP
D05714 Remacemide hydrochloride (USAN)
D06146 Tiletamine hydrochloride (USP)
D07058 Acamprosate (INN); Aotal (TN)
D07283 Esketamine (INN)
D07978 Flupirtine (INN)
D07979 Flupirtine D-gluconate; Katadolon (TN)
D08064 Ifenprodil (INN)
D08098 Ketamine (INN); Tekam (TN)
D08100 Ketobemidone (INN)
D08101 Ketobemidone hydrochloride; Ketogan (TN)
D08121 Levomethadone (INN)
D08122 Levomethadone hydrochloride; L-polamidon (TN)
D08174 Memantine (INN); Exiba (TN)
D08195 Methadone (BAN)
D08596 Tiletamine (INN)
D09917 Latrepirdine (USAN/INN)
D09918 Latrepirdine dihydrochloride (USAN); Dimebolin; Dimebon
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NMDE4_HUMAN

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Related Literatures of Post-Translational Modification

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