PSPC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSPC_HUMAN
• UniProt AC: P11686
• Protein Name: Pulmonary surfactant-associated protein C
• Gene Name: SFTPC
• Organism: Homo sapiens (Human).
• Sequence Length: 197
• Subcellular Localization: Secreted, extracellular space, surface film.
• Protein Description: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces..
• Protein Sequence: MDVGSKEVLMESPPDYSAAPRGRFGIPCCPVHLKRLLIVVVVVVLIVVVIVGALLMGLHMSQKHTEMVLEMSIGAPEAQQRLALSEHLVTTATFSIGSTGLVVYDYQQLLIAYKPAPGTCCYIMKIAPESIPSLEALNRKVHNFQMECSLQAKPAVPTSKLGQAEGRDAGSAPSGGDPAFLGMAVNTLCGEVPLYYI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MDVGSKEVLMESP --CCCCCCEECCCCC	46.01	-
16	Phosphorylation	LMESPPDYSAAPRGR CCCCCCCCCCCCCCC	13.14	22817900
28	S-palmitoylation	RGRFGIPCCPVHLKR CCCCCCCCCHHHHHH	3.75	11509324
29	S-palmitoylation	GRFGIPCCPVHLKRL CCCCCCCCHHHHHHH	3.11	11509324
187	Phosphorylation	FLGMAVNTLCGEVPL HHHHHHHHHCCCCCE	19.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSPC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSPC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSPC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNJB9_HUMAN	DNAJB9	physical	18400946
DJC10_HUMAN	DNAJC10	physical	18400946
GRP78_HUMAN	HSPA5	physical	18400946
PSPC_HUMAN	SFTPC	physical	25416956
SC61G_HUMAN	SEC61G	physical	25416956
SC22A_HUMAN	SEC22A	physical	25416956
TMM79_HUMAN	TMEM79	physical	25416956
SYNE4_HUMAN	SYNE4	physical	25416956
NPTXR_HUMAN	NPTXR	physical	28514442
CBX8_HUMAN	CBX8	physical	28514442
CBX6_HUMAN	CBX6	physical	28514442
SREC2_HUMAN	SCARF2	physical	28514442
PHC2_HUMAN	PHC2	physical	28514442
BMI1_HUMAN	BMI1	physical	28514442
SCRB1_HUMAN	SCARB1	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442
VPP2_HUMAN	ATP6V0A2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610913: Pulmonary surfactant metabolism dysfunction 2 (SMDP2)
• 267450: Respiratory distress syndrome in premature infants (RDS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Palmitoylation

"Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptidewith two palmitoylated cysteine residues, whereas SP-B lackscovalently linked fatty acyl groups.";
Curstedt T., Johansson J., Persson P., Eklund A., Robertson B.,Loewenadler B., Joernvall H.;
Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990).
Cited for: PALMITOYLATION AT CYS-28 AND CYS-29.
PubMed: 2326260

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-16, AND MASSSPECTROMETRY.
PubMed: 18083107