dbPTM

NPTXR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NPTXR_HUMAN
UniProt AC	O95502
Protein Name	Neuronal pentraxin receptor
Gene Name	NPTXR
Organism	Homo sapiens (Human).
Sequence Length	500
Subcellular Localization	Membrane Single-pass type II membrane protein .
Protein Description	May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses..
Protein Sequence	MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	ALPGGADNASVASGA CCCCCCCCCCHHCCC	33.31	UniProtKB CARBOHYD
81	O-linked_Glycosylation	LPGAPAASAHPLPPG CCCCCCCCCCCCCCC	29.26	OGP
97	Phosphorylation	LFSRFLCTPLAAACP CHHHCCCHHHHHHCC	24.39	-
105	Phosphorylation	PLAAACPSGAQQGDA HHHHHCCCCHHCCCC	46.79	-
128	Phosphorylation	EELLLLQSTAEQLRQ HHHHHHHHHHHHHHH	29.56	-
129	Phosphorylation	ELLLLQSTAEQLRQT HHHHHHHHHHHHHHH	22.66	-
216	N-linked_Glycosylation	QELPARVNLSAAPAP HHCCCCCCCCCCCCC	23.79	UniProtKB CARBOHYD
233	Phosphorylation	AVPTGLHSKMDQLEG CCCCCHHHHHHHHHH	34.42	-
251	Ubiquitination	AQVLALEKERVALSH HHHHHHHHHHHHHCC	52.23	-
259	Phosphorylation	ERVALSHSSRRQRQE HHHHHCCHHHHHHHH	23.36	27251275
260	Phosphorylation	RVALSHSSRRQRQEV HHHHCCHHHHHHHHH	26.51	27251275
297	Phosphorylation	PPDAFKISIPIRNNY CCCCEEEEEEECCCH	23.93	24719451
304	Phosphorylation	SIPIRNNYMYARVRK EEEECCCHHHHHHHH	8.61	-
306	Phosphorylation	PIRNNYMYARVRKAL EECCCHHHHHHHHHH	4.86	-
336	Phosphorylation	SSGTGQGTPFSYSVP CCCCCCCCCCEEECC	17.17	22210691
339	Phosphorylation	TGQGTPFSYSVPGQA CCCCCCCEEECCCCC	20.08	22210691
340	Phosphorylation	GQGTPFSYSVPGQAN CCCCCCEEECCCCCC	17.67	22210691
463	N-linked_Glycosylation	AQVLGIANCTAPLLG HHHHCCCCCCCCCCC	23.04	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL2	O95198	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NPTXR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NPTXR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NPTXR_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NPTXR_HUMAN

Related Literatures of Post-Translational Modification