MDR1_HUMAN - dbPTM
MDR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MDR1_HUMAN
UniProt AC P08183
Protein Name Multidrug resistance protein 1
Gene Name ABCB1
Organism Homo sapiens (Human).
Sequence Length 1280
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells..
Protein Sequence MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationFFKLNNKSEKDKKEK
CCCCCCCCHHHHCCC		52.5920068231
33PhosphorylationDKKEKKPTVSVFSMF
HHCCCCCCEEHHHHH		34.0018767875
35PhosphorylationKEKKPTVSVFSMFRY
CCCCCCEEHHHHHHC		21.6618767875
91N-linked_GlycosylationNLEDLMSNITNRSDI
CHHHHHHHCCCCHHC		31.01UniProtKB CARBOHYD
94N-linked_GlycosylationDLMSNITNRSDINDT
HHHHHCCCCHHCCCC		37.35UniProtKB CARBOHYD
99N-linked_GlycosylationITNRSDINDTGFFMN
CCCCHHCCCCCCCCC		45.87UniProtKB CARBOHYD
178UbiquitinationLNTRLTDDVSKINEG
HHHHCCCCHHHHHCC		41.16-
181UbiquitinationRLTDDVSKINEGIGD
HCCCCHHHHHCCCHH		49.77-
185UbiquitinationDVSKINEGIGDKIGM
CHHHHHCCCHHHHHH		25.37-
207UbiquitinationFFTGFIVGFTRGWKL
HHHHHHHCCCCCCCC		17.25-
215UbiquitinationFTRGWKLTLVILAIS
CCCCCCCHHHHHHHH		18.4321890473
242UbiquitinationILSSFTDKELLAYAK
HHHCCCCHHHHHHHH		47.40-
249UbiquitinationKELLAYAKAGAVAEE
HHHHHHHHHHHHHHH		34.38-
263PhosphorylationEVLAAIRTVIAFGGQ
HHHHHHHHHHHHCCC		15.3424732914
271UbiquitinationVIAFGGQKKELERYN
HHHHCCCHHHHHHHH		52.03-
279UbiquitinationKELERYNKNLEEAKR
HHHHHHHCCHHHHHH		54.7121890473
303UbiquitinationNISIGAAFLLIYASY
CCCHHHHHHHHHHHH		5.9021890473
308UbiquitinationAAFLLIYASYALAFW
HHHHHHHHHHHHHHH		6.78-
316UbiquitinationSYALAFWYGTTLVLS
HHHHHHHHCCEEEEE		9.72-
325UbiquitinationTTLVLSGEYSIGQVL
CEEEEECCCCHHHHH		32.50-
367UbiquitinationGAAYEIFKIIDNKPS
CHHHHHHHHHCCCCC		44.4021890473
372UbiquitinationIFKIIDNKPSIDSYS
HHHHHCCCCCHHHCC		36.07-
380UbiquitinationPSIDSYSKSGHKPDN
CCHHHCCCCCCCCCC		52.83-
384AcetylationSYSKSGHKPDNIKGN
HCCCCCCCCCCCCCC		58.5519817263
389UbiquitinationGHKPDNIKGNLEFRN
CCCCCCCCCCCEEEC		48.26-
405SumoylationHFSYPSRKEVKILKG
EECCCCHHHEEEEEC		71.80-
405SumoylationHFSYPSRKEVKILKG
EECCCCHHHEEEEEC		71.80-
408SumoylationYPSRKEVKILKGLNL
CCCHHHEEEEECCEE		43.33-
408SumoylationYPSRKEVKILKGLNL
CCCHHHEEEEECCEE		43.33-
411UbiquitinationRKEVKILKGLNLKVQ
HHHEEEEECCEEEEC		65.90-
419O-linked_GlycosylationGLNLKVQSGQTVALV
CCEEEECCCCEEEEE		35.5429351928
422PhosphorylationLKVQSGQTVALVGNS
EEECCCCEEEEECCC		15.98-
451UbiquitinationYDPTEGMVSVDGQDI
CCCCCCCEEECCCCC		8.0921890473
455UbiquitinationEGMVSVDGQDIRTIN
CCCEEECCCCCEEEE		25.5521890473
490PhosphorylationTIAENIRYGRENVTM
EHHHHHHHCCCCCCH		19.4125247763
496PhosphorylationRYGRENVTMDEIEKA
HHCCCCCCHHHHHHH		30.4129083192
511UbiquitinationVKEANAYDFIMKLPH
HHHHCHHHHHHCCCH		24.96-
515UbiquitinationNAYDFIMKLPHKFDT
CHHHHHHCCCHHHHC		54.7921890473
519UbiquitinationFIMKLPHKFDTLVGE
HHHCCCHHHHCCCCC		42.8921890473
522PhosphorylationKLPHKFDTLVGERGA
CCCHHHHCCCCCCCC		26.86-
536UbiquitinationAQLSGGQKQRIAIAR
CCCCCCHHHHHHHHH		44.83-
545UbiquitinationRIAIARALVRNPKIL
HHHHHHHHHHCCEEE		2.87-
553UbiquitinationVRNPKILLLDEATSA
HHCCEEEEEECCCCC		6.88-
575UbiquitinationVVQVALDKARKGRTT
HHHHHHHHHHCCCEE		51.44-
581UbiquitinationDKARKGRTTIVIAHR
HHHHCCCEEEEEEEC		29.55-
590PhosphorylationIVIAHRLSTVRNADV
EEEEECCCCCCCCCE		25.4730108239
591PhosphorylationVIAHRLSTVRNADVI
EEEECCCCCCCCCEE		28.2430108239
609UbiquitinationDDGVIVEKGNHDELM
CCCEEEECCCHHHHH		54.86-
617UbiquitinationGNHDELMKEKGIYFK
CCHHHHHHHCCEEEE		69.74-
619UbiquitinationHDELMKEKGIYFKLV
HHHHHHHCCEEEEEE		45.12-
627PhosphorylationGIYFKLVTMQTAGNE
CEEEEEEEEECCCCE		17.6329759185
630PhosphorylationFKLVTMQTAGNEVEL
EEEEEEECCCCEEEE		26.2229759185
644PhosphorylationLENAADESKSEIDAL
ECCCCCCCHHHHCHH		41.8729116813
645UbiquitinationENAADESKSEIDALE
CCCCCCCHHHHCHHH		50.49-
646PhosphorylationNAADESKSEIDALEM
CCCCCCHHHHCHHHC		49.4129116813
654PhosphorylationEIDALEMSSNDSRSS
HHCHHHCCCCCCHHH		19.3330576142
655PhosphorylationIDALEMSSNDSRSSL
HCHHHCCCCCCHHHH		43.2620068231
658PhosphorylationLEMSSNDSRSSLIRK
HHCCCCCCHHHHHHH		38.0118669648
660PhosphorylationMSSNDSRSSLIRKRS
CCCCCCHHHHHHHHH		33.1922496350
661PhosphorylationSSNDSRSSLIRKRST
CCCCCHHHHHHHHHH		27.0622115753
667PhosphorylationSSLIRKRSTRRSVRG
HHHHHHHHHCHHHCC		29.3322817900
671PhosphorylationRKRSTRRSVRGSQAQ
HHHHHCHHHCCCHHH		16.938095261
675PhosphorylationTRRSVRGSQAQDRKL
HCHHHCCCHHHHCCC		16.2768999603
683PhosphorylationQAQDRKLSTKEALDE
HHHHCCCCHHHHHHC		40.2322817900
684PhosphorylationAQDRKLSTKEALDES
HHHCCCCHHHHHHCC		43.2546156625
696PhosphorylationDESIPPVSFWRIMKL
HCCCCCCCHHHHHCC		25.5146156601
733PhosphorylationPAFAIIFSKIIGVFT
HHHHHHHHHHHCHHH		16.7324719451
744UbiquitinationGVFTRIDDPETKRQN
CHHHCCCCHHHHHHH		40.33-
762UbiquitinationFSLLFLALGIISFIT
HHHHHHHHHHHHHHH		5.72-
808UbiquitinationVSWFDDPKNTTGALT
CCCCCCCCCCCCHHH		74.13-
8262-HydroxyisobutyrylationANDAAQVKGAIGSRL
HHHHHHHCCHHHHHH		30.46-
826UbiquitinationANDAAQVKGAIGSRL
HHHHHHHCCHHHHHH		30.46-
851UbiquitinationGTGIIISFIYGWQLT
CCCHHHHHHHHHHHH		3.3421890473
915UbiquitinationVSLTQEQKFEHMYAQ
HHCCHHHHHHHHHHH		52.5521890473
941PhosphorylationKAHIFGITFSFTQAM
CEEEEEEEEECHHHH		17.3825072903
943PhosphorylationHIFGITFSFTQAMMY
EEEEEEEECHHHHHH		20.8025072903
945PhosphorylationFGITFSFTQAMMYFS
EEEEEECHHHHHHHH		17.7725072903
950PhosphorylationSFTQAMMYFSYAGCF
ECHHHHHHHHHCCHH		4.0125072903
952PhosphorylationTQAMMYFSYAGCFRF
HHHHHHHHHCCHHHH		9.1525072903
953PhosphorylationQAMMYFSYAGCFRFG
HHHHHHHHCCHHHHH		9.3425072903
1015PhosphorylationIIMIIEKTPLIDSYS
EEEEEECCCCCCCCC		15.5511662771
1023PhosphorylationPLIDSYSTEGLMPNT
CCCCCCCCCCCCCCC		26.3211662783
1029UbiquitinationSTEGLMPNTLEGNVT
CCCCCCCCCEECCEE		43.2421890473
1030PhosphorylationTEGLMPNTLEGNVTF
CCCCCCCCEECCEEE		21.9511662795
1062UbiquitinationGLSLEVKKGQTLALV
CCEEEEECCCEEEEE		62.52-
1072PhosphorylationTLALVGSSGCGKSTV
EEEEECCCCCCHHHH		31.9728857561
1087PhosphorylationVQLLERFYDPLAGKV
HHHHHHHCCCCCCCE		23.917330693
10932-HydroxyisobutyrylationFYDPLAGKVLLDGKE
HCCCCCCCEEECCHH		24.89-
1093UbiquitinationFYDPLAGKVLLDGKE
HCCCCCCCEEECCHH		24.8921890473
1099UbiquitinationGKVLLDGKEIKRLNV
CCEEECCHHHHHHCH		56.80-
1100UbiquitinationKVLLDGKEIKRLNVQ
CEEECCHHHHHHCHH		60.3121890473
1102MethylationLLDGKEIKRLNVQWL
EECCHHHHHHCHHHH		52.50-
1148UbiquitinationSQEEIVRAAKEANIH
CHHHHHHHHHHHCHH		16.40-
1156UbiquitinationAKEANIHAFIESLPN
HHHHCHHHHHHHCCC		11.87-
1160PhosphorylationNIHAFIESLPNKYST
CHHHHHHHCCCCCCC		44.2927067055
1164UbiquitinationFIESLPNKYSTKVGD
HHHHCCCCCCCCCCC		38.3421890473
1172UbiquitinationYSTKVGDKGTQLSGG
CCCCCCCCCCCCCCH		58.91-
1181UbiquitinationTQLSGGQKQRIAIAR
CCCCCHHHHHHHHHH		44.83-
1212UbiquitinationALDTESEKVVQEALD
CCCCCCHHHHHHHHH		57.92-
12202-HydroxyisobutyrylationVVQEALDKAREGRTC
HHHHHHHHHHCCCEE		50.63-
1220UbiquitinationVVQEALDKAREGRTC
HHHHHHHHHHCCCEE		50.63-
1267PhosphorylationLLAQKGIYFSMVSVQ
HHHHCCCCEEEEEEC		9.7768725333
1269PhosphorylationAQKGIYFSMVSVQAG
HHCCCCEEEEEECCC		10.9968725339
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
661SPhosphorylationKinasePRKCAP17252
GPS
661SPhosphorylationKinasePKC_GROUP-PhosphoELM
661SPhosphorylationKinasePKC-FAMILY-GPS
667SPhosphorylationKinasePRKACAP17612
GPS
667SPhosphorylationKinasePKC_GROUP-PhosphoELM
667SPhosphorylationKinasePRKCAP17252
GPS
667SPhosphorylationKinasePKA_GROUP-PhosphoELM
667SPhosphorylationKinasePKA-FAMILY-GPS
667SPhosphorylationKinasePKC-FAMILY-GPS
671SPhosphorylationKinasePKC_GROUP-PhosphoELM
671SPhosphorylationKinasePRKACAP17612
GPS
671SPhosphorylationKinasePKC-FAMILY-GPS
671SPhosphorylationKinasePRKCAP17252
GPS
683SPhosphorylationKinasePKA_GROUP-PhosphoELM
683SPhosphorylationKinasePKC-FAMILY-GPS
683SPhosphorylationKinasePKA-FAMILY-GPS
683SPhosphorylationKinasePRKACAP17612
GPS
-KUbiquitinationE3 ubiquitin ligaseFBXO15Q8NCQ5
PMID:24658274
-KUbiquitinationE3 ubiquitin ligaseFBXO21O94952
PMID:26299618
-KUbiquitinationE3 ubiquitin ligaseNEDD4P46934
PMID:26006083
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MDR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MDR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DHX9_HUMANDHX9physical
14769796
PIM1_HUMANPIM1physical
20460432
PSB8_HUMANPSMB8physical
15488952
FBX15_HUMANFBXO15physical
23465077
UBA7_HUMANUBA7physical
23465077
SIN1_HUMANMAPKAP1physical
21988832
CD4_HUMANCD4physical
21988832
BCCIP_HUMANBCCIPphysical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612244Inflammatory bowel disease 13 (IBD13)
Kegg Drug
D00140 Erythromycin (JP16/USP/INN); EM; Akne-mycin (TN); Eryc (TN); Erygel (TN); Pce (TN); Staticin (TN); T
D00184 Ciclosporin (JP16); Cyclosporine (USP); Gengraf (TN); Neoral (TN); Restasis (TN); Sandimmune (TN)
D00251 Captopril (JP16/USP/INN); Apopril (TN); Capoten (TN)
D00252 Carbamazepine (JP16/USP/INN); Equetro (TN); Tegretol (TN)
D00255 Carvedilol (JAN/USAN/INN); Artist (TN); Coreg (TN)
D00276 Clarithromycin (JP16/USP/INN); CAM; Biaxin (TN)
D00297 Digitoxin (JP16/USP/INN); Crystodigin (TN)
D00298 Digoxin (JP16/USP); Lanoxicaps (TN); Lanoxin (TN)
D00319 Felodipine (JAN/USP/INN); Plendil (TN)
D00326 Fluoxetine (USAN/INN); Fluoxetine (TN)
D00336 Glibenclamide (JP16/INN); Glyburide (USP); Diabeta (TN); Glynase (TN); Micronase (TN)
D00350 Itraconazole (JP16/USAN); Itrizole (TN); Sporanox (TN)
D00351 Ketoconazole (JP16/USP); Nizoral (TN); Xolegel (TN)
D00427 Ritonavir (JAN/USAN/INN); Norvir (TN)
D00429 Saquinavir (JAN/USP/INN); Fortovase (TN)
D00491 Paclitaxel (JAN/USP/INN); Abraxane (TN); Taxol (TN)
D00506 Phenobarbital (JP16/USP/INN); Luminal (TN)
D00512 Phenytoin (JP16/USP/INN); Dilantin (TN)
D00565 Fenofibrate (JAN/INN); Antara (TN); Lipantil (TN); Lipofen (TN); Tricor (TN); Triglide (TN)
D00570 Colchicine (JP16/USP); Colchicine (TN)
D00616 Diltiazem hydrochloride (JP16/USP); Cardizem (TN); Cartia XT (TN); Dilacor XR (TN); Dilt-CD (TN)
D00619 Verapamil hydrochloride (JP16/USP); Calan (TN); Covera-hs (TN); Vasolan (TN); Verelan (TN)
D00629 Nitrendipine (JP16/USAN/INN); Baypress (TN)
D00636 Amiodarone hydrochloride (JP16/USAN); Ancaron (TN); Cordarone (TN)
D00640 Propafenone hydrochloride (JP16/USP); Rythmol (TN)
D00642 Quinidine gluconate (USP); Quinaglute (TN)
D00643 Quinidine polygalacturonate; Cardioquin (TN)
D00664 Cetirizine hydrochloride (JP16/USAN); Zyrtec (TN)
D00671 Fexofenadine hydrochloride (JP16/USAN); Allegra (TN)
D00701 Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN)
D00729 Loperamide hydrochloride (JAN/USP); Imodium (TN)
D00753 Sirolimus (USAN/INN); Rapamune (TN); Rapamycin (TN)
D00822 Citalopram hydrobromide (USAN); Celexa (TN)
D00823 Fluoxetine hydrochloride (JAN/USP); Prozac (TN)
D00824 Fluvoxamine maleate (JP16/USAN); Luvox (TN)
D00825 Sertraline hydrochloride (JAN/USAN); Zoloft (TN)
D00851 Erythromycin estorate (JAN); Erythromycin estolate (USP); Ilosone (TN)
D00899 Nelfinavir mesilate (JAN); Nelfinavir mesylate (USAN/INN); Viracept (TN)
D01061 Irinotecan hydrochloride hydrate (JAN); Irinotecan hydrochloride (USAN); CPT 11; CPT-11; Campto (TN)
D01068 Vinblastine sulfate (JP16/USP); Exal (TN); Velban (TN)
D01145 Azelnidipine (JP16/INN); Calblock (TN)
D01160 Saquinavir mesilate (JAN); Saquinavir mesylate (USP); Invirase (TN)
D01213 Tolvaptan (JAN/USAN/INN); Samsca (TN)
D01236 Conivaptan hydrochloride (JAN/USAN); Vaprisol (TN)
D01250 Berberine chloride hydrate (JP16); Kyoberin (TN)
D01275 Doxorubicin hydrochloride (JP16/USP); Adriacin (TN); Adriamycin (TN); Doxil (TN); Rubex (TN)
D01358 Mianserin hydrochloride (JAN/USAN); Tetramide (TN)
D01361 Erythromycin ethylsuccinate (JP16/USP); E.E.S. (TN); Eryped (TN); Erythrocin W (TN)
D01441 Imatinib mesilate (JAN); Imatinib mesylate (USAN); Gleevec (TN); Glivec (TN)
D02009 Erythromycin lactobionate (JP16/USP); EML; Erythrocin (TN)
D02103 Phenytoin sodium for injection (JP16); Phenytoin sodium (USP); Aleviatin (TN); Dilantin (TN)
D02134 Azithromycin hydrate (JP16); Zithromac (TN); Zmax (TN)
D02168 Nogitecan hydrochloride (JAN); Topotecan hydrochloride (USAN); Hycamtin (TN)
D02184 Erythromycin stearate (JP16/USP); ES; Bristamycin (TN)
D02260 Paroxetine hydrochloride hydrate (JAN); Paxil (TN)
D02272 Quinidine sulfate hydrate (JP16); Quinidine sulfate (USP); Quinidex (TN)
D02356 Verapamil (USAN/INN)
D02360 Sertraline (INN)
D02362 Paroxetine (USP/INN); Paroxetine (TN)
D02498 Lopinavir mixture with ritonavir; Lopinavir - ritonavir mixt; Kaletra (TN)
D02523 Erythromycin acistrate (USAN); EA; Erasis (TN)
D02524 Erythromycin gluceptate (USP); Erythromycin glucoheptonate; Ilotycin gluceptate (TN)
D02525 Erythromycin propionate (USAN)
D02537 Dronedarone (INN)
D02555 Posaconazole (USAN/INN); Noxafil (TN)
D02714 Everolimus (JAN/USAN/INN); Afinitor (TN); Votubia (TN); Zortress (TN)
D02910 Amiodarone (USAN/INN)
D03012 Avasimibe (USAN/INN)
D03208 Aliskiren (USAN/INN); Rasilez (TN)
D03213 Apixaban (JAN/USAN/INN); Eliquis (TN)
D03258 Berberine tannate (JP16); Erben (TN)
D03293 Berberine sulfate hydrate (JAN); Erben (TN)
D03415 Carvedilol phosphate hydrate (JAN); Carvedilol phosphate (USAN); Coreg CR (TN)
D03830 Diltiazem malate (USAN); Tiamate (TN)
D03899 Doxorubicin (USAN/INN); ADR; Adriblastina (TN)
D03914 Dronedarone hydrochloride (USAN); Multaq (TN)
D04024 Lapatinib tosilate hydrate (JAN); Lapatinib ditosylate (USAN); Tykerb (TN)
D04054 Erythromycin salnacedin (USAN)
D05374 Paroxetine hydrochloride (USP); Paxil (TN)
D05375 Paroxetine mesylate (USAN); Brisdelle (TN); Pexeva (TN)
D05700 Ranolazine (USAN/INN); Ranexa (TN)
D05701 Ranolazine hydrochloride (USAN)
D06008 Tariquidar (USAN/INN)
D06387 Zosuquidar trihydrochloride (USAN)
D06390 Azithromycin (USP); AZM; Zmax (TN)
D06412 Aliskiren fumarate (JAN/USAN); Aliskiren hemifumarate; Tekturna (TN)
D06413 Nilotinib hydrochloride hydrate (JAN); Tasigna (TN)
D06645 Sitagliptin phosphate hydrate (JAN); Sitagliptin phosphate (USAN); Sitagliptin phosphate monohydrate
D06670 Maraviroc (JAN/INN); Selzentry (TN)
D07077 Ambrisentan (JAN/INN); Letairis (TN); Volibris (TN)
D07082 Dabigatran etexilate methanesulfonate (JAN); Dabigatran etexilate mesylate (USAN); Pradaxa (TN)
D07086 Rivaroxaban (JAN/USAN/INN); Xarelto (TN)
D07113 Loperamide oxide (INN)
D07144 Dabigatran etexilate (USAN/INN); Pradaxa (TN)
D07184 Talinolol (INN)
D07486 Azithromycin (INN); AZM; Azasite (TN); Azithromycin (TN)
D07704 Citalopram (USP/INN); Citadur (TN)
D07705 Citalopram hydrochloride; Seropram (TN)
D07748 Conivaptan (INN)
D07845 Diltiazem (INN); Surazem (TN)
D07909 Erythromycin thiocyanate; Erythrocin (TN)
D07910 Erythromycin stinoprate (INN); Erysec (TN)
D07958 Fexofenadine (INN); Telfast (TN)
D07984 Fluvoxamine (INN)
D08066 Imatinib (INN); Glamox (TN)
D08086 Irinotecan (INN); Biotecan (TN)
D08108 Lapatinib (INN)
D08144 Loperamide (INN); Diamide (TN)
D08259 Nelfinavir (INN); Viracept (TN)
D08356 Phenobarbital diethylamine; Gratusminal (TN)
D08435 Propafenone (INN); Propafenon hexal (TN)
D08458 Quinidine (BAN); Kinidin (TN)
D08459 Quinidine phenylethylbarbiturate; Quinidine 5-ethyl 5-phenyl barbiturate; Natisedine (TN)
D08516 Sitagliptin (Prop.INN)
D08618 Topotecan (BAN); Hycamtin (TN)
D08675 Vinblastine (INN); Vinblastina (TN)
D08890 Choline fenofibrate (USAN/INN)
D08953 Nilotinib (USAN/INN)
D08996 Saxagliptin (INN)
D09012 Telaprevir (JAN/USAN/INN); Incivek (TN); Incivo (TN)
D09017 Ticagrelor (USAN/INN); Brilinta (TN)
D09318 Indacaterol (USAN/INN)
D09319 Indacaterol maleate (JAN/USAN); Arcapta neohaler (TN)
D09546 Edoxaban tosilate hydrate (JAN); LIXIANA (TN)
D09710 Edoxaban (USAN/INN)
DrugBank
DB01193Acebutolol
DB00316Acetaminophen
DB00945Acetylsalicylic acid
DB00171Adenosine triphosphate
DB05773ado-trastuzumab emtansine
DB08916Afatinib
DB00518Albendazole
DB00802Alfentanil
DB00523Alitretinoin
DB00915Amantadine
DB00345Aminohippurate
DB01118Amiodarone
DB00321Amitriptyline
DB00381Amlodipine
DB00701Amprenavir
DB00276Amsacrine
DB06605Apixaban
DB01169Arsenic trioxide
DB00637Astemizole
DB01072Atazanavir
DB00335Atenolol
DB01076Atorvastatin
DB06626Axitinib
DB00972Azelastine
DB00207Azithromycin
DB01086Benzocaine
DB01244Bepridil
DB00443Betamethasone
DB00810Biperiden
DB08873Boceprevir
DB06616Bosutinib
DB08870Brentuximab vedotin
DB01200Bromocriptine
DB00921Buprenorphine
DB00490Buspirone
DB06772Cabazitaxel
DB00201Caffeine
DB08907Canagliflozin
DB00796Candesartan
DB01197Captopril
DB00564Carbamazepine
DB08889Carfilzomib
DB01136Carvedilol
DB00520Caspofungin
DB00608Chloroquine
DB00477Chlorpromazine
DB00672Chlorpropamide
DB01239Chlorprothixene
DB02659Cholic Acid
DB01340Cilazapril
DB00501Cimetidine
DB00537Ciprofloxacin
DB00515Cisplatin
DB00215Citalopram
DB01211Clarithromycin
DB00349Clobazam
DB00845Clofazimine
DB00882Clomifene
DB01242Clomipramine
DB00575Clonidine
DB00758Clopidogrel
DB00257Clotrimazole
DB00363Clozapine
DB01394Colchicine
DB00286Conjugated Estrogens
DB08865Crizotinib
DB00531Cyclophosphamide
DB00091Cyclosporine
DB06695Dabigatran etexilate
DB08912Dabrafenib
DB00970Dactinomycin
DB06292Dapagliflozin
DB01254Dasatinib
DB00694Daunorubicin
DB04840Debrisoquin
DB01151Desipramine
DB00967Desloratadine
DB01234Dexamethasone
DB00514Dextromethorphan
DB00829Diazepam
DB00586Diclofenac
DB00255Diethylstilbestrol
DB01396Digitoxin
DB00390Digoxin
DB00320Dihydroergotamine
DB00343Diltiazem
DB00975Dipyridamole
DB01248Docetaxel
DB01184Domperidone
DB00590Doxazosin
DB01142Doxepin
DB00997Doxorubicin
DB00470Dronabinol
DB04855Dronedarone
DB00216Eletriptan
DB00584Enalapril
DB08899Enzalutamide
DB00751Epinastine
DB01253Ergonovine
DB00696Ergotamine
DB00530Erlotinib
DB00199Erythromycin
DB00783Estradiol
DB01196Estramustine
DB04573Estriol
DB00655Estrone
DB00977Ethinyl Estradiol
DB00773Etoposide
DB06414Etravirine
DB00973Ezetimibe
DB01023Felodipine
DB00813Fentanyl
DB06702Fesoterodine
DB00950Fexofenadine
DB08874Fidaxomicin
DB00196Fluconazole
DB00472Fluoxetine
DB00875Flupentixol
DB00623Fluphenazine
DB00690Flurazepam
DB08906Fluticasone furoate
DB00176Fluvoxamine
DB00317Gefitinib
DB00441Gemcitabine
DB01016Glyburide
DB00027Gramicidin D
DB00502Haloperidol
DB00741Hydrocortisone
DB01050Ibuprofen
DB00619Imatinib
DB00458Imipramine
DB05039Indacaterol
DB00224Indinavir
DB00328Indomethacin
DB00762Irinotecan
DB01167Itraconazole
DB08820Ivacaftor
DB00602Ivermectin
DB01221Ketamine
DB01587Ketazolam
DB01026Ketoconazole
DB00709Lamivudine
DB00555Lamotrigine
DB00448Lansoprazole
DB01259Lapatinib
DB00480Lenalidomide
DB01202Levetiracetam
DB01137Levofloxacin
DB08918Levomilnacipran
DB00451Levothyroxine
DB00281Lidocaine
DB08882Linagliptin
DB00279Liothyronine
DB01583Liotrix
DB00722Lisinopril
DB08827Lomitapide
DB00836Loperamide
DB01601Lopinavir
DB00455Loratadine
DB00678Losartan
DB00227Lovastatin
DB00742Mannitol
DB00934Maprotiline
DB00643Mebendazole
DB00358Mefloquine
DB00351Megestrol acetate
DB00371Meprobamate
DB00333Methadone
DB00563Methotrexate
DB00959Methylprednisolone
DB00264Metoprolol
DB01110Miconazole
DB00683Midazolam
DB00834Mifepristone
DB08893Mirabegron
DB00305Mitomycin
DB01204Mitoxantrone
DB00295Morphine
DB00688Mycophenolate mofetil
DB01203Nadolol
DB01183Naloxone
DB00704Naltrexone
DB01149Nefazodone
DB00220Nelfinavir
DB01400Neostigmine
DB00622Nicardipine
DB01115Nifedipine
DB04868Nilotinib
DB00401Nisoldipine
DB01595Nitrazepam
DB01054Nitrendipine
DB00585Nizatidine
DB00717Norethindrone
DB00334Olanzapine
DB00338Omeprazole
DB01229Paclitaxel
DB00213Pantoprazole
DB00715Paroxetine
DB06589Pazopanib
DB00790Perindopril
DB01174Phenobarbital
DB00252Phenytoin
DB01100Pimozide
DB08860Pitavastatin
DB08910Pomalidomide
DB08901Ponatinib
DB01263Posaconazole
DB00175Pravastatin
DB00457Prazosin
DB00860Prednisolone
DB00635Prednisone
DB01032Probenecid
DB00396Progesterone
DB01069Promethazine
DB01182Propafenone
DB00571Propranolol
DB00344Protriptyline
DB01224Quetiapine
DB01103Quinacrine
DB00908Quinidine
DB00468Quinine
DB00863Ranitidine
DB00234Reboxetine
DB08896Regorafenib
DB00206Reserpine
DB01045Rifampicin
DB08864Rilpivirine
DB00734Risperidone
DB00503Ritonavir
DB06228Rivaroxaban
DB00778Roxithromycin
DB00936Salicylic acid
DB01232Saquinavir
DB00747Scopolamine
DB01037Selegiline
DB01104Sertraline
DB06207Silodosin
DB06290Simeprevir
DB00641Simvastatin
DB00877Sirolimus
DB01261Sitagliptin
DB08934Sofosbuvir
DB00398Sorafenib
DB01208Sparfloxacin
DB00421Spironolactone
DB00428Streptozocin
DB01138Sulfinpyrazone
DB00669Sumatriptan
DB01268Sunitinib
DB00864Tacrolimus
DB00675Tamoxifen
DB05521Telaprevir
DB00966Telmisartan
DB06287Temsirolimus
DB01162Terazosin
DB00624Testosterone
DB08816Ticagrelor
DB00373Timolol
DB06212Tolvaptan
DB01030Topotecan
DB00539Toremifene
DB00656Trazodone
DB00831Trifluoperazine
DB00508Triflupromazine
DB00440Trimethoprim
DB00726Trimipramine
DB01361Troleandomycin
DB01339Vecuronium
DB00285Venlafaxine
DB00661Verapamil
DB00570Vinblastine
DB00541Vincristine
DB00361Vinorelbine
DB08828Vismodegib
DB04877Voacamine
DB00495Zidovudine
Regulatory Network of MDR1_HUMAN

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