FBX15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX15_HUMAN
• UniProt AC: Q8NCQ5
• Protein Name: F-box only protein 15
• Gene Name: FBXO15
• Organism: Homo sapiens (Human).
• Sequence Length: 510
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MATGRGRILQQHWLGLQTLRGPSRGGGAARGRARAFGCRKGPGVKLSAGSAALRCHAGGGQHWESSFSCCSGFLDGMPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEKIAMSMSFLSVQDKEAGYWKKEYITKQIASVKAALADILKPVNPYTGLPVKTKEALRIFGLGWAIILKEKGGKEYIMEHVDLSINDTSVTVIWYGKKWPCLASLSTLDLCGMTPVFTDWYKTPTKHRLRWHSLIAKYNLSHLTISTMIGCDRLIRIFCLHPGLLVGVWKKEEELAFVMANLHFHHLVERSTLGSATIPYELPPHSPFLDDSPEYGLHGYQLHVDLHSGGVFYLCGTFRNLFTKRGNIENGHVKLIVIHLKNNREHLPLIGKVGLSWKTDIFDGCIKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVNLVLYLSIAKINHWFGTEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATGRGRILQ -----CCCCCCHHHH	26.55	27762562
18	Phosphorylation	QHWLGLQTLRGPSRG HHCCCCEECCCCCCC	24.38	27762562
140	Phosphorylation	SVEKIAMSMSFLSVQ CHHHHHHHHHHHCCC	11.40	23663014
142	Phosphorylation	EKIAMSMSFLSVQDK HHHHHHHHHHCCCCC	18.74	23663014
145	Phosphorylation	AMSMSFLSVQDKEAG HHHHHHHCCCCCCCC	18.74	23663014
153	Phosphorylation	VQDKEAGYWKKEYIT CCCCCCCCCCHHHHH	22.54	23663014
158	Phosphorylation	AGYWKKEYITKQIAS CCCCCHHHHHHHHHH	23.83	-
160	Phosphorylation	YWKKEYITKQIASVK CCCHHHHHHHHHHHH	18.92	-
210	Phosphorylation	KEKGGKEYIMEHVDL EECCCCEEEEEEEEE	14.73	25348772
218	Phosphorylation	IMEHVDLSINDTSVT EEEEEEEEECCCEEE	18.19	25348772
222	Phosphorylation	VDLSINDTSVTVIWY EEEEECCCEEEEEEC	22.17	24850871
223	Phosphorylation	DLSINDTSVTVIWYG EEEECCCEEEEEECC	20.75	24850871
225	Phosphorylation	SINDTSVTVIWYGKK EECCCEEEEEECCCC	13.17	24850871
229	Phosphorylation	TSVTVIWYGKKWPCL CEEEEEECCCCCCCE	14.14	24850871
488	Phosphorylation	WIRETEEYLIVNLVL EEECCCHHHHHHHHH	8.76	22817900
496	Phosphorylation	LIVNLVLYLSIAKIN HHHHHHHHHHHHHHH	7.30	22817900
510	Phosphorylation	NHWFGTEY------- HHHCCCCC-------	24.56	20736484

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDR1_HUMAN	ABCB1	physical	23465077
UBA7_HUMAN	UBA7	physical	23465077
CRLS1_HUMAN	CRLS1	physical	24703837
OS9_HUMAN	OS9	physical	26186194
HINT3_HUMAN	HINT3	physical	26186194
CBPA6_HUMAN	CPA6	physical	26186194
CBPA6_HUMAN	CPA6	physical	28514442
HINT3_HUMAN	HINT3	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.