TMG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMG1_HUMAN
• UniProt AC: O14668
• Protein Name: Transmembrane gamma-carboxyglutamic acid protein 1
• Gene Name: PRRG1
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MGRVFLTGEKANSILKRYPRANGFFEEIRQGNIERECKEEFCTFEEAREAFENNEKTKEFWSTYTKAQQGESNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTEGHIPFPQHLNIITPPPPPDEVFDSSGLSPGFLGYVVGRSDSVSTRLSNCDPPPTYEEATGQVNLQRSETEPHLDPPPEYEDIVNSNSASAIPMVPVVTTIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	RVFLTGEKANSILKR CEEECCHHHHHHHHH	54.97	21890473
10	Ubiquitination	RVFLTGEKANSILKR CEEECCHHHHHHHHH	54.97	21890473
13	Phosphorylation	LTGEKANSILKRYPR ECCHHHHHHHHHCCC	33.87	24719451
18	Phosphorylation	ANSILKRYPRANGFF HHHHHHHCCCCCCHH	8.76	-
66	Ubiquitination	EFWSTYTKAQQGESN HHHHHHHHHHCCCCC	33.51	2189047
114	Phosphorylation	RNKTRRQTVTEGHIP CCCCCCCCCCCCCCC	27.81	20068231
116	Phosphorylation	KTRRQTVTEGHIPFP CCCCCCCCCCCCCCC	39.37	20068231
130	Phosphorylation	PQHLNIITPPPPPDE CCCCCCCCCCCCCCH	26.41	20068231
141	Phosphorylation	PPDEVFDSSGLSPGF CCCHHCCCCCCCCCH	18.16	20068231
142	Phosphorylation	PDEVFDSSGLSPGFL CCHHCCCCCCCCCHH	45.67	20068231
145	Phosphorylation	VFDSSGLSPGFLGYV HCCCCCCCCCHHHEE	26.88	20068231
151	Phosphorylation	LSPGFLGYVVGRSDS CCCCHHHEEECCCCC	8.29	20068231
156	Phosphorylation	LGYVVGRSDSVSTRL HHEEECCCCCHHHHH	28.45	26437602
158	Phosphorylation	YVVGRSDSVSTRLSN EEECCCCCHHHHHHC	21.15	21712546
160	Phosphorylation	VGRSDSVSTRLSNCD ECCCCCHHHHHHCCC	16.26	28787133
161	Phosphorylation	GRSDSVSTRLSNCDP CCCCCHHHHHHCCCC	33.21	24719451
164	Phosphorylation	DSVSTRLSNCDPPPT CCHHHHHHCCCCCCC	31.92	29507054
171	Phosphorylation	SNCDPPPTYEEATGQ HCCCCCCCHHHHCCC	49.71	25850435
172	Phosphorylation	NCDPPPTYEEATGQV CCCCCCCHHHHCCCE	19.97	25850435
184	Phosphorylation	GQVNLQRSETEPHLD CCEECCCCCCCCCCC	35.59	26356563
186	Phosphorylation	VNLQRSETEPHLDPP EECCCCCCCCCCCCC	56.94	26657352
196	Phosphorylation	HLDPPPEYEDIVNSN CCCCCCCHHHHCCCC	25.36	27642862
218	Ubiquitination	VPVVTTIK------- CCEEEECC-------	52.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMG1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMG1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.