SCNNA_HUMAN - dbPTM
SCNNA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCNNA_HUMAN
UniProt AC P37088
Protein Name Amiloride-sensitive sodium channel subunit alpha
Gene Name SCNN1A
Organism Homo sapiens (Human).
Sequence Length 669
Subcellular Localization Apical cell membrane
Multi-pass membrane protein . Cell projection, cilium . Cytoplasmic granule . Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Cell projection, cilium, flagellum . In the oviduct and bronchus, located on cilia in
Protein Description Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception..
Protein Sequence MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22 (in isoform 5)Ubiquitination-65.4621906983
22 (in isoform 3)Ubiquitination-65.4621906983
22 (in isoform 1)Ubiquitination-65.4621906983
22 (in isoform 4)Ubiquitination-65.4621906983
22UbiquitinationQSTPGLMKGNKREEQ
CCCCCCCCCCCCCCC		65.4621906983
54PhosphorylationALIEFHRSYRELFEF
HHHHHHHHHHHHHHH		21.7025954137
55PhosphorylationLIEFHRSYRELFEFF
HHHHHHHHHHHHHHH		14.2025954137
67PhosphorylationEFFCNNTTIHGAIRL
HHHHCCCCHHHHHHH		17.0725954137
81 (in isoform 2)Ubiquitination-26.3321906983
144UbiquitinationPYRYPEIKEELEELD
CCCCHHHHHHHHHHH		43.4023503661
154PhosphorylationLEELDRITEQTLFDL
HHHHHHHCHHHHHHH		23.96-
166PhosphorylationFDLYKYSSFTTLVAG
HHHHHHCCCCEEEEC		24.4224719451
167UbiquitinationDLYKYSSFTTLVAGS
HHHHHCCCCEEEECC		5.0723503661
174PhosphorylationFTTLVAGSRSRRDLR
CCEEEECCCCHHHCC		19.8324719451
203 (in isoform 2)Ubiquitination-11.53-
203UbiquitinationPPHGARRARSVASSL
CCCCHHHHHHHHHHH		11.5323503661
220 (in isoform 1)Ubiquitination-49.6121906983
220 (in isoform 4)Ubiquitination-49.6121906983
220 (in isoform 3)Ubiquitination-49.6121906983
220 (in isoform 5)Ubiquitination-49.6121906983
220UbiquitinationNNPQVDWKDWKIGFQ
CCCCCCHHHCHHHHH		49.6121906983
223UbiquitinationQVDWKDWKIGFQLCN
CCCHHHCHHHHHCCC		42.9823503661
225PhosphorylationDWKDWKIGFQLCNQN
CHHHCHHHHHCCCCC		10.6724719451
233UbiquitinationFQLCNQNKSDCFYQT
HHCCCCCCCCCEEEH		37.6021906983
233 (in isoform 1)Ubiquitination-37.6021906983
233 (in isoform 5)Ubiquitination-37.6021906983
233PhosphorylationFQLCNQNKSDCFYQT
HHCCCCCCCCCEEEH		37.6024719451
233 (in isoform 4)Ubiquitination-37.6021906983
243UbiquitinationCFYQTYSSGVDAVRE
CEEEHHHCCHHHHHH		32.2123503661
246UbiquitinationQTYSSGVDAVREWYR
EHHHCCHHHHHHHHH		42.7623503661
279 (in isoform 2)Ubiquitination-2.1921906983
279UbiquitinationEDTLGNFIFACRFNQ
CCCHHHEEEEEECCC		2.1923503661
282UbiquitinationLGNFIFACRFNQVSC
HHHEEEEEECCCCCC		3.3923503661
292 (in isoform 2)Ubiquitination-11.7021906983
314PhosphorylationTFNDKNNSNLWMSSM
EEECCCCCCCEECCC		42.5722210691
375PhosphorylationNLRPGVETSISMRKE
CCCCCCEEEHHHCHH		29.0224719451
376PhosphorylationLRPGVETSISMRKET
CCCCCEEEHHHCHHH		10.1224719451
378PhosphorylationPGVETSISMRKETLD
CCCEEEHHHCHHHHH		16.58-
383PhosphorylationSISMRKETLDRLGGD
EHHHCHHHHHHHCCC		36.67-
411PhosphorylationENLYPSKYTQQVCIH
HHCCCCCCHHHHHHH		17.7027732954
412PhosphorylationNLYPSKYTQQVCIHS
HCCCCCCHHHHHHHH		19.0927732954
419PhosphorylationTQQVCIHSCFQESMI
HHHHHHHHHHCHHHH		9.1927732954
434PhosphorylationKECGCAYIFYPRPQN
HHHCCEEEEECCCCC		1.1024719451
435PhosphorylationECGCAYIFYPRPQNV
HHCCEEEEECCCCCC		4.4724719451
451 (in isoform 5)Phosphorylation-30.7122210691
452 (in isoform 5)Phosphorylation-25.0022210691
458 (in isoform 5)Phosphorylation-11.1422210691
460 (in isoform 5)Phosphorylation-3.2922210691
510 (in isoform 4)Ubiquitination-42.2221906983
523UbiquitinationNKRNGVAKVNIFFKE
CCCCCEEEEEEEEEH		33.1523503661
529UbiquitinationAKVNIFFKELNYKTN
EEEEEEEEHHCCCCC		51.012190698
529 (in isoform 1)Ubiquitination-51.0121906983
534UbiquitinationFFKELNYKTNSESPS
EEEHHCCCCCCCCCC		39.9123503661
546UbiquitinationSPSVTMVTLLSNLGS
CCCEEHHHHHHHCCH		15.9123503661
551 (in isoform 5)Ubiquitination-6.6621906983
552UbiquitinationVTLLSNLGSQWSLWF
HHHHHHCCHHHHHHC		23.2623503661
557UbiquitinationNLGSQWSLWFGSSVL
HCCHHHHHHCCHHHH		3.9123503661
582UbiquitinationDLLVIMFLMLLRRFR
HHHHHHHHHHHHHHH		0.9923503661
588 (in isoform 2)Ubiquitination-7.2221906983
588UbiquitinationFLMLLRRFRSRYWSP
HHHHHHHHHHHHCCC		7.2223503661
593UbiquitinationRRFRSRYWSPGRGGR
HHHHHHHCCCCCCCC		9.2823503661
594PhosphorylationRFRSRYWSPGRGGRG
HHHHHHCCCCCCCCC		14.4520740360
663PhosphorylationSAGASSSTCPLGGP-
CCCCCCCCCCCCCC-		21.7917596527
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseNEDD4LQ96PU5
PMID:12522688
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCNNA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCNNA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NEDD4_HUMANNEDD4physical
10642508
NEDD4_HUMANNEDD4physical
11244092
NED4L_HUMANNEDD4Lphysical
11244092
HECW1_HUMANHECW1physical
11244092
ITCH_HUMANITCHphysical
11244092
NED4L_HUMANNEDD4Lphysical
14556380
TS101_HUMANTSG101physical
14556380
WWP1_HUMANWWP1physical
14556380
UBC9_HUMANUBE2Iphysical
14556380
NED4L_HUMANNEDD4Lphysical
17502380
EPN1_HUMANEPN1physical
16574660
HGS_HUMANHGSphysical
20675381
NED4L_HUMANNEDD4Lphysical
16416336
UBP2_HUMANUSP2physical
18701608
NED4L_HUMANNEDD4Lphysical
18701608
SERP1_HUMANSERP1physical
22526458
SCNNB_HUMANSCNN1Bphysical
22526458
UBP8_HUMANUSP8physical
23297398
LHS1_YEASTLHS1physical
23645669
HYOU1_HUMANHYOU1physical
23645669
NED4L_HUMANNEDD4Lphysical
26651153
DERL1_HUMANDERL1physical
28137758
SCNNB_HUMANSCNN1Bphysical
27903760
SCNNG_HUMANSCNN1Gphysical
27903760
Drug and Disease Associations
Kegg Disease
H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4), including: Pseudohypoaldosteronism type I
H00892 Bronchiectasis with or without elevated sweat chloride
OMIM Disease
264350Pseudohypoaldosteronism 1, autosomal recessive (PHA1B)
613021Bronchiectasis with or without elevated sweat chloride 2 (BESC2)
Kegg Drug
D00386 Triamterene (JP16/USP/INN); Dyrenium (TN)
D00649 Amiloride hydrochloride (USP); Midamor (TN)
D07447 Amiloride (INN); Amiclaran (TN)
DrugBank
DB00594Amiloride
DB00384Triamterene
Regulatory Network of SCNNA_HUMAN

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