SCNNB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNNB_HUMAN
• UniProt AC: P51168
• Protein Name: Amiloride-sensitive sodium channel subunit beta
• Gene Name: SCNN1B
• Organism: Homo sapiens (Human).
• Sequence Length: 640
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . Apical membrane of epithelial cells.
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..
• Protein Sequence: MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	KGLHRLQKGPGYTYK HHHHHHHCCCCCCCH	72.21	-
20	Phosphorylation	RLQKGPGYTYKELLV HHHCCCCCCCHHEEE	15.27	22210691
21	Phosphorylation	LQKGPGYTYKELLVW HHCCCCCCCHHEEEE	33.75	22210691
182	Ubiquitination	TSSSASEKICNAHGC CCCCHHHHHHHHHHC	50.49	-
260	N-linked_Glycosylation	AEPCNYRNFTSIFYP CCCCCCCCCCEEEEC	33.90	UniProtKB CARBOHYD
296	Ubiquitination	PGTEFGLKLILDIGQ CCCHHHCEEEEEECC	33.58	-
350	Ubiquitination	SIGVLVDKLQRMGEP CHHHHHHHHHHCCCC	38.75	-
413	Ubiquitination	YPLPRGEKYCNNRDF EECCCCCCCCCCCCC	58.91	-
488	Phosphorylation	QSTNITLSRKGIVKL CCCCEEEECCCEEEE	24.24	-
498	Phosphorylation	GIVKLNIYFQEFNYR CEEEEEEEEEECCCH	9.72	-
504	Phosphorylation	IYFQEFNYRTIEESA EEEEECCCHHHHHHH	17.91	-
561	Phosphorylation	KLVALAKSLRQRRAQ HHHHHHHHHHHHHHH	24.15	22496350
570	Phosphorylation	RQRRAQASYAGPPPT HHHHHHHHHCCCCCC	11.93	-
594	Phosphorylation	NFGFQPDTAPRSPNT HCCCCCCCCCCCCCC	45.29	-
615	Phosphorylation	QALPIPGTPPPNYDS HCCCCCCCCCCCCCC	27.54	24719451
633	Phosphorylation	QPLDVIESDSEGDAI CCCCEEECCCCCCCC	35.00	24719451
635	Phosphorylation	LDVIESDSEGDAI-- CCEEECCCCCCCC--	53.40	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:19953087
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:17502380

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNNB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNNB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_HUMAN	NEDD4	physical	10642508
NEDD4_HUMAN	NEDD4	physical	11244092
NED4L_HUMAN	NEDD4L	physical	11244092
HECW1_HUMAN	HECW1	physical	11244092
ITCH_HUMAN	ITCH	physical	11244092
WWP2_HUMAN	WWP2	physical	11244092
EPN1_HUMAN	EPN1	physical	16574660
SGK1_HUMAN	SGK1	physical	20237237
NEDD4_HUMAN	NEDD4	physical	20237237
NED4L_HUMAN	NEDD4L	physical	16416336
UBP2_HUMAN	USP2	physical	18701608
SCNNG_HUMAN	SCNN1G	physical	22526458
SCNNA_HUMAN	SCNN1A	physical	22526458
SERP1_HUMAN	SERP1	physical	22526458
NED4L_HUMAN	NEDD4L	physical	15814530
UBP8_HUMAN	USP8	physical	23297398
HGS_HUMAN	HGS	physical	20675381

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.