ERMIN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERMIN_HUMAN
• UniProt AC: Q8TAM6
• Protein Name: Ermin
• Gene Name: ERMN
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)..
• Protein Sequence: MTDVPATFTQAECNGDKPPENGQQTITKISEELTDVDSPLPHYRVEPSLEGALTKGSQEERRKLQGNMLLNSSMEDKMLKENPEEKLFIVHKAITDLSLQETSADEMTFREGHQWEKIPLSGSNQEIRRQKERITEQPLKEEEDEDRKNKGHQAAEIEWLGFRKPSQADMLHSKHDEEQKVWDEEIDDDDDDNCNNDEDEVRVIEFKKKHEEVSQFKEEGDASEDSPLSSASSQAVTPDEQPTLGKKSDISRNAYSRYNTISYRKIRKGNTKQRIDEFESMMHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	43.00	26270265
5 (in isoform 2)	Phosphorylation	-	28.52	26270265
54	Phosphorylation	PSLEGALTKGSQEER CCHHCCCCCCCHHHH	32.59	25247763
72	Phosphorylation	QGNMLLNSSMEDKML HHHHHHCCHHHHHHH	30.91	29507054
73	Phosphorylation	GNMLLNSSMEDKMLK HHHHHCCHHHHHHHH	25.72	29507054
80	Acetylation	SMEDKMLKENPEEKL HHHHHHHHHCHHHCE	52.53	19810435
95	Phosphorylation	FIVHKAITDLSLQET EEEHHHHCCCCCCCC	35.43	29523821
98	Phosphorylation	HKAITDLSLQETSAD HHHHCCCCCCCCCCC	30.71	29523821
102	Phosphorylation	TDLSLQETSADEMTF CCCCCCCCCCCCCCC	19.09	29083192
103	Phosphorylation	DLSLQETSADEMTFR CCCCCCCCCCCCCCC	32.73	29083192
108	Phosphorylation	ETSADEMTFREGHQW CCCCCCCCCCCCCCC	19.93	29083192
123	Phosphorylation	EKIPLSGSNQEIRRQ EECCCCCCHHHHHHH	31.78	24076635
166	Phosphorylation	WLGFRKPSQADMLHS ECCCCCHHHHHHHCC	40.82	28555341
173	Phosphorylation	SQADMLHSKHDEEQK HHHHHHCCCCCHHHH	27.94	28555341
179	Phosphorylation	HSKHDEEQKVWDEEI CCCCCHHHHHHCCCC	43.48	27251275
214	Phosphorylation	KKKHEEVSQFKEEGD HHHHHHHHHHHHCCC	32.93	-
226	Phosphorylation	EGDASEDSPLSSASS CCCCCCCCCCCCCCC	24.56	-
230	Phosphorylation	SEDSPLSSASSQAVT CCCCCCCCCCCCCCC	39.59	-
233	Phosphorylation	SPLSSASSQAVTPDE CCCCCCCCCCCCCCC	23.13	-
237	Phosphorylation	SASSQAVTPDEQPTL CCCCCCCCCCCCCCC	28.21	-
255	Phosphorylation	SDISRNAYSRYNTIS CCCCCCHHHHCCCCC	9.38	21712546
256	Phosphorylation	DISRNAYSRYNTISY CCCCCHHHHCCCCCC	26.36	21712546
260	Phosphorylation	NAYSRYNTISYRKIR CHHHHCCCCCCEECC	11.45	20886841
262	Phosphorylation	YSRYNTISYRKIRKG HHHCCCCCCEECCCC	19.49	25332170
263	Phosphorylation	SRYNTISYRKIRKGN HHCCCCCCEECCCCC	16.45	21712546
271	Phosphorylation	RKIRKGNTKQRIDEF EECCCCCCCCCHHHH	36.90	26270265
280	Phosphorylation	QRIDEFESMMHL--- CCHHHHHHHHCC---	27.08	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERMIN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERMIN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERMIN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.