SCNNA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNNA_MOUSE
• UniProt AC: Q61180
• Protein Name: Amiloride-sensitive sodium channel subunit alpha
• Gene Name: Scnn1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 699
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Cell projection, cilium . Cytoplasmic granule . Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Cell projection, cilium, flagellum . In the oviduct and bronchus, located on cilia in
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception..
• Protein Sequence: MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEPSEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGTTPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Acetylation	SMKGNNFKEQDLCPP CCCCCCCCHHHCCCC	57.50	15620087
202	Methylation	RQAGGRRRSTRDLRG CCCCCCCCCHHHHCC	40.81	-
208	Methylation	RRSTRDLRGALPHPL CCCHHHHCCCCCCHH	32.40	-
236	Phosphorylation	SARSASSSVRDNNPQ CCHHHCHHCCCCCCC	20.76	22871156
261	Phosphorylation	QLCNQNKSDCFYQTY ECCCCCCCCCEEEHH	47.35	26239621
267	Phosphorylation	KSDCFYQTYSSGVDA CCCCEEEHHHCCHHH	17.62	26239621
270	Phosphorylation	CFYQTYSSGVDAVRE CEEEHHHCCHHHHHH	32.21	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Nedd4l	Q8CFI0	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNNA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNNA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_MOUSE	Nedd4	physical	15123669
DERL1_MOUSE	Derl1	physical	28137758

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.