SCNNB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNNB_MOUSE
• UniProt AC: Q9WU38
• Protein Name: Amiloride-sensitive sodium channel subunit beta
• Gene Name: Scnn1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 638
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . Apical membrane of epithelial cells.
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..
• Protein Sequence: MPVKKYLLKCLHRLQKGPGYTYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLDELMEAVLEKILAPEASHSNTTRTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEETLPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYPLPEGEKYCNNRDFPDWAYCYLNLQMSVTQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRPHGEVYPDQQTLPIPGTPPPNYDSLRLQPLDTMESDSEVEAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	S-palmitoylation	HGPKRIICEGPKKKA CCCCEEEEECHHHHH	4.62	28154191
135	N-linked_Glycosylation	APEASHSNTTRTLNF CCCCCCCCCCEEEEE	39.79	-
141	N-linked_Glycosylation	SNTTRTLNFTIWNHT CCCCEEEEEEECCCC	31.25	-
205	N-linked_Glycosylation	GTVCTLRNFTSATQA CCEEEEECCCCHHHH	47.89	-
333	Phosphorylation	FIREEGIYAMAGTET HHCCCCEEEECCCCC	10.94	28059163
341	Phosphorylation	AMAGTETSIGVLVDK EECCCCCCHHHHHHH	15.88	28059163
557	S-palmitoylation	IIKLVASCKGLRRRR HHHHHHHCCCHHHHC	2.67	28154191
613	Phosphorylation	QTLPIPGTPPPNYDS CCCCCCCCCCCCCCC	27.54	22817900
628	Phosphorylation	LRLQPLDTMESDSEV CCCCCCCCCCCCCCC	30.44	21183079
631	Phosphorylation	QPLDTMESDSEVEAI CCCCCCCCCCCCCCC	35.30	22817900
633	Phosphorylation	LDTMESDSEVEAI-- CCCCCCCCCCCCC--	53.47	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCNNB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNNB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNNB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_MOUSE	Nedd4	physical	17544362
NEDD4_MOUSE	Nedd4	physical	15123669

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.