1433F_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433F_BOVIN
• UniProt AC: P68509
• Protein Name: 14-3-3 protein eta
• Gene Name: YWHAH
• Organism: Bos taurus (Bovine).
• Sequence Length: 246
• Subcellular Localization: Cytoplasm.
• Protein Description: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)..
• Protein Sequence: MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLALLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDREQLLQ ------CCHHHHHHH	42.56	-
25	Phosphorylation	ERYDDMASAMKAVTE HHHHHHHHHHHHHHH	23.43	-
59	Phosphorylation	VVGARRSSWRVISSI HHCCCCCCCHHHHHH	19.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1433F_BOVIN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1433F_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433F_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of 1433F_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.