LAPM5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAPM5_HUMAN
• UniProt AC: Q13571
• Protein Name: Lysosomal-associated transmembrane protein 5
• Gene Name: LAPTM5
• Organism: Homo sapiens (Human).
• Sequence Length: 262
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein .
• Protein Description: May have a special functional role during embryogenesis and in adult hematopoietic cells..
• Protein Sequence: MDPRLSTVRQTCCCFNVRIATTALAIYHVIMSVLLFIEHSVEVAHGKASCKLSQMGYLRIADLISSFLLITMLFIISLSLLIGVVKNREKYLLPFLSLQIMDYLLCLLTLLGSYIELPAYLKLASRSRASSSKFPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEDMPHNQFIKMMIIFSIAFITVLIFKVYMFKCVWRCYRLIKCMNSVEEKRNSKMLQKVVLPSYEEALSLPSKTPEGGPAPPPYSEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	GKASCKLSQMGYLRI CCCCCHHHHCCHHHH	12.01	20049867
57	Phosphorylation	CKLSQMGYLRIADLI CHHHHCCHHHHHHHH	6.35	20049867
65	Phosphorylation	LRIADLISSFLLITM HHHHHHHHHHHHHHH	23.49	20049867
66	Phosphorylation	RIADLISSFLLITML HHHHHHHHHHHHHHH	16.96	20049867
71	Phosphorylation	ISSFLLITMLFIISL HHHHHHHHHHHHHHH	14.06	20049867
77	Phosphorylation	ITMLFIISLSLLIGV HHHHHHHHHHHHHHH	13.69	20049867
97	Phosphorylation	KYLLPFLSLQIMDYL HCHHHHHHHHHHHHH	20.71	18452278
114	Phosphorylation	LLTLLGSYIELPAYL HHHHHHHHCHHHHHH	9.16	18452278
197	Phosphorylation	IFSIAFITVLIFKVY HHHHHHHHHHHHHHH	11.65	-
204	Phosphorylation	TVLIFKVYMFKCVWR HHHHHHHHHHHHHHH	9.45	22817900
217	Ubiquitination	WRCYRLIKCMNSVEE HHHHHHHHHHHHHHH	31.83	-
225	Ubiquitination	CMNSVEEKRNSKMLQ HHHHHHHHHHHHHHH	43.29	21906983
229	Ubiquitination	VEEKRNSKMLQKVVL HHHHHHHHHHHHHHC	47.37	21890473
233	Ubiquitination	RNSKMLQKVVLPSYE HHHHHHHHHHCCCHH	30.28	21890473
238	Phosphorylation	LQKVVLPSYEEALSL HHHHHCCCHHHHHCC	40.80	28796482
239	Phosphorylation	QKVVLPSYEEALSLP HHHHCCCHHHHHCCC	18.82	28796482
244	Phosphorylation	PSYEEALSLPSKTPE CCHHHHHCCCCCCCC	45.33	21815630
247	Phosphorylation	EEALSLPSKTPEGGP HHHHCCCCCCCCCCC	55.22	20068231
248	Ubiquitination	EALSLPSKTPEGGPA HHHCCCCCCCCCCCC	67.18	2190698
259	Phosphorylation	GGPAPPPYSEV---- CCCCCCCCCCC----	24.20	28796482
260	Phosphorylation	GPAPPPYSEV----- CCCCCCCCCC-----	37.34	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:19953087
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:22009753

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAPM5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAPM5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GGA3_HUMAN	GGA3	physical	17116753
LAMP1_HUMAN	LAMP1	physical	22733818
TNAP3_HUMAN	TNFAIP3	physical	22733818
TNAP3_HUMAN	TNFAIP3	physical	15231748
EPS15_HUMAN	EPS15	physical	15231748
NEDD4_HUMAN	NEDD4	physical	15231748
RL40_HUMAN	UBA52	physical	15231748
RN168_HUMAN	RNF168	physical	15231748
AN13A_HUMAN	ANKRD13A	physical	15231748
TM1L2_HUMAN	TOM1L2	physical	15231748
UBP13_HUMAN	USP13	physical	15231748
DCNL1_HUMAN	DCUN1D1	physical	15231748
NED4L_HUMAN	NEDD4L	physical	15231748
WWP1_HUMAN	WWP1	physical	15231748
EPN3_HUMAN	EPN3	physical	15231748
SMUF2_HUMAN	SMURF2	physical	15231748
HEYL_HUMAN	HEYL	physical	15231748
HEY1_HUMAN	HEY1	physical	15231748
EPN1_HUMAN	EPN1	physical	15231748
DISP1_HUMAN	DISP1	physical	25416956
LRAD1_HUMAN	LDLRAD1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.