SCNNG_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNNG_RAT
• UniProt AC: P37091
• Protein Name: Amiloride-sensitive sodium channel subunit gamma
• Gene Name: Scnn1g
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 650
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Apical membrane of epithelial cells.
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..
• Protein Sequence: MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCMNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNKENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHKAKDWWARRQTPPSTETPSSRQGQDNPALDTDDDLPTFTSAMRLPPAPGSTVPGTPPPRYNTLRLDRAFSSQLTDTQLTNEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MAPGEKIKAKIKK --CCCHHHHHHHHHH	56.26	-
8	Ubiquitination	MAPGEKIKAKIKKNL CCCHHHHHHHHHHCC	55.48	-
10	Ubiquitination	PGEKIKAKIKKNLPV CHHHHHHHHHHCCCC	50.48	-
12	Ubiquitination	EKIKAKIKKNLPVRG HHHHHHHHHCCCCCC	34.60	-
13	Ubiquitination	KIKAKIKKNLPVRGP HHHHHHHHCCCCCCC	68.16	9351815PubMed
26	Ubiquitination	GPQAPTIKDLMHWYC CCCCCCHHHHHHHHH	47.49	-
210	N-linked_Glycosylation	VGFQLCSNDTSDCAT EEEEEECCCCCCCHH	56.43	-
272	N-linked_Glycosylation	GMSCDARNFTLFHHP CCCCCCCCEEEEECC	35.66	-
498	N-linked_Glycosylation	QQINKKLNKTDLAKL HHHHHHCCHHHHHHH	54.80	-
599	Phosphorylation	QDNPALDTDDDLPTF CCCCCCCCCCCCCCC	42.02	18308722
623	Phosphorylation	PGSTVPGTPPPRYNT CCCCCCCCCCCCCCC	26.93	22108457

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
623	T	Phosphorylation	Kinase	MAPK1	P63086	GPS
623	T	Phosphorylation	Kinase	MAPK3	P21708	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNNG_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNNG_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TS101_RAT	Tsg101	physical	14556380
UBC9_HUMAN	UBE2I	physical	14556380
NEDD4_RAT	Nedd4	physical	8665844

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.