TS101_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TS101_RAT
• UniProt AC: Q6IRE4
• Protein Name: Tumor susceptibility gene 101 protein
• Gene Name: Tsg101
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 391
• Subcellular Localization: Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Late endosome membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody, Midbody ring . Nucleus . Mainl
• Protein Description: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity)..
• Protein Sequence: MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTAAGPPNTSYLPSMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTAGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVSESQLK ------CCCCHHHHH	17.34	-
48	Phosphorylation	SYVFNDGSSRELVNL EEEECCCCCCEEEEE	29.14	27097102
49	Phosphorylation	YVFNDGSSRELVNLT EEECCCCCCEEEEEC	34.99	27097102
221	Phosphorylation	AGPSRDGTISEDTIR CCCCCCCCCCHHHHH	26.14	22108457
238	Acetylation	LISAVSDKLRWRMKE HHHHHHHHHHHHHHH	32.23	22902405
310	Phosphorylation	LEKMENQSENNDIDE HHHHHHCCCCCCCCC	54.60	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TS101_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TS101_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TS101_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AATF_HUMAN	AATF	physical	14761944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.