SRMS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRMS_HUMAN
• UniProt AC: Q9H3Y6
• Protein Name: Tyrosine-protein kinase Srms
• Gene Name: SRMS
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Cytoplasm . Localizes to punctate cytoplasmic structures.
• Protein Description: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. [PubMed: 23822091 Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues]
• Protein Sequence: MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	ALEEGGGYIFARRLS EEEECCCEEEEEECC	8.99	29496907
94	Phosphorylation	YIFARRLSGQPSAGL EEEEEECCCCCCCCE	33.30	23312004
98	Phosphorylation	RRLSGQPSAGLVPIT EECCCCCCCCEEECE	27.38	23312004
121	Phosphorylation	TLSDQPWYFSGVSRT CCCCCCCCCCCCCHH	8.44	29496907
149	Phosphorylation	GAFLIRPSESSLGGY CEEEECCCCCCCCCC	40.02	29496907
152	Phosphorylation	LIRPSESSLGGYSLS EECCCCCCCCCCEEE	27.29	29496907
156	Phosphorylation	SESSLGGYSLSVRAQ CCCCCCCCEEEEEEE	12.49	29496907
157	Phosphorylation	ESSLGGYSLSVRAQA CCCCCCCEEEEEEEE	19.90	29496907
159	Phosphorylation	SLGGYSLSVRAQAKV CCCCCEEEEEEEEEE	12.01	24719451
169	Phosphorylation	AQAKVCHYRVSMAAD EEEEECCEEEEECCC	13.95	29496907
178	Phosphorylation	VSMAADGSLYLQKGR EEECCCCCEEEECCC	17.87	29496907
180	Phosphorylation	MAADGSLYLQKGRLF ECCCCCEEEECCCCC	14.58	29496907
196	Phosphorylation	GLEELLTYYKANWKL CHHHHHHHHHHCCCC	11.70	29496907
197	Phosphorylation	LEELLTYYKANWKLI HHHHHHHHHHCCCCC	9.82	29496907
262	Phosphorylation	VAIKVIKSANMKLTD HHHHHHHHCCCCHHH	17.47	22210691
268	Phosphorylation	KSANMKLTDLAKEIQ HHCCCCHHHHHHHHH	24.37	22210691
276	Phosphorylation	DLAKEIQTLKGLRHE HHHHHHHHHHCCCCH	35.78	22210691
299	Phosphorylation	CSGGEPVYIVTELMR CCCCCEEEEEEHHHH	10.61	30140170
339	Phosphorylation	CQVAEGMSYLEEQRV HHHHHCCHHHHHHHH	37.11	29496907
376	Ubiquitination	FGLARLLKDDIYSPS HHHHHHHHCCCCCCC	58.93	27667366
380	Phosphorylation	RLLKDDIYSPSSSSK HHHHCCCCCCCCCCC	22.86	23822091
381	Phosphorylation	LLKDDIYSPSSSSKI HHHCCCCCCCCCCCC	20.74	29496907
384	Phosphorylation	DDIYSPSSSSKIPVK CCCCCCCCCCCCCCE	41.85	29496907
385	Phosphorylation	DIYSPSSSSKIPVKW CCCCCCCCCCCCCEE	39.73	29496907
386	Phosphorylation	IYSPSSSSKIPVKWT CCCCCCCCCCCCEEC	36.23	29496907
387	Ubiquitination	YSPSSSSKIPVKWTA CCCCCCCCCCCEECC	53.64	27667366
400	Phosphorylation	TAPEAANYRVFSQKS CCCCHHCEEEEECCC	11.92	29496907
404	Phosphorylation	AANYRVFSQKSDVWS HHCEEEEECCCCHHH	33.57	29496907
443	Phosphorylation	LQQIMRGYRLPRPAA HHHHHHCCCCCCCCC	9.90	29496907
456	Phosphorylation	AACPAEVYVLMLECW CCCCHHHEEEEHHHH	4.56	30140170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRMS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRMS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRMS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSPB1_HUMAN	HSPB1	physical	25852190

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.