GLIS3_HUMAN - dbPTM
GLIS3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLIS3_HUMAN
UniProt AC Q8NEA6
Protein Name Zinc finger protein GLIS3
Gene Name GLIS3
Organism Homo sapiens (Human).
Sequence Length 775
Subcellular Localization Nucleus.
Protein Description Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity)..
Protein Sequence MMVQRLGLISPPASQVSTACNQISPSLQRAMNAANLNIPPSDTRSLISRESLASTTLSLTESQSASSMKQEWSQGYRALPSLSNHGSQNGLDLGDLLSLPPGTSMSSNSVSNSLPSYLFGTESSHSPYPSPRHSSTRSHSARSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGSRASPANLSPQPEVYGHFLGVRGSCIPQPRPVPGSQKGVLVAPGGLALPAYGEDGALEHERMQQLEHGGLQPGLVNHMVVQHGLPGPDSQSAGLFKTERLEEFPGSTVDLPPAPPLPPLPPPPGPPPPYHAHAHLHHPELGPHAQQLALPQATLDDDGEMDGIGGKHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPSFEDCLVPTSMGQASFDVFHRAFSTHSGITVYDLPSSSSSLFGESLRSGAEDATFLQISTVDRCPSQLSSVYTEG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationVQRLGLISPPASQVS
CEECCCCCCCHHHHH		29.8525159151
14PhosphorylationGLISPPASQVSTACN
CCCCCCHHHHHHHHH		36.5724043423
17PhosphorylationSPPASQVSTACNQIS
CCCHHHHHHHHHHHC		11.5824043423
18PhosphorylationPPASQVSTACNQISP
CCHHHHHHHHHHHCH		36.0524043423
24PhosphorylationSTACNQISPSLQRAM
HHHHHHHCHHHHHHH		9.9325159151
24 (in isoform 2)Phosphorylation-9.9328348404
26PhosphorylationACNQISPSLQRAMNA
HHHHHCHHHHHHHHH		30.2824043423
35 (in isoform 2)Phosphorylation-31.0728348404
37 (in isoform 2)Phosphorylation-44.5228348404
41 (in isoform 2)Phosphorylation-46.3828348404
41PhosphorylationANLNIPPSDTRSLIS
HHCCCCCHHHHHHHC		46.3824043423
43PhosphorylationLNIPPSDTRSLISRE
CCCCCHHHHHHHCHH		26.8824043423
45 (in isoform 2)Phosphorylation-31.9527251275
45PhosphorylationIPPSDTRSLISRESL
CCCHHHHHHHCHHHH		31.9524719451
46 (in isoform 2)Phosphorylation-3.5727251275
48PhosphorylationSDTRSLISRESLAST
HHHHHHHCHHHHHHH		34.9824719451
53 (in isoform 2)Phosphorylation-17.7027251275
85 (in isoform 2)Phosphorylation-33.6329083192
129 (in isoform 2)Acetylation-41.04-
134PhosphorylationPYPSPRHSSTRSHSA
CCCCCCCCCCCCCCH		34.38-
135PhosphorylationYPSPRHSSTRSHSAR
CCCCCCCCCCCCCHH		23.01-
136PhosphorylationPSPRHSSTRSHSARS
CCCCCCCCCCCCHHH		38.92-
140PhosphorylationHSSTRSHSARSKKRA
CCCCCCCCHHHHHCC		26.9926329039
145 (in isoform 2)Phosphorylation-44.12-
149PhosphorylationRSKKRALSLSPLSDG
HHHHCCCCCCCCCCC		26.3027251275
151PhosphorylationKKRALSLSPLSDGIG
HHCCCCCCCCCCCCC		22.0327251275
152 (in isoform 2)Phosphorylation-40.97-
167PhosphorylationDFNTIIRTSPTSLVA
CHHCEEECCCCCEEE		28.7524719451
168PhosphorylationFNTIIRTSPTSLVAY
HHCEEECCCCCEEEE		19.1424114839
170PhosphorylationTIIRTSPTSLVAYIN
CEEECCCCCEEEEEC		34.1628857561
171PhosphorylationIIRTSPTSLVAYING
EEECCCCCEEEEECC		25.0028857561
182PhosphorylationYINGSRASPANLSPQ
EECCCCCCCCCCCCC		24.3630108239
187PhosphorylationRASPANLSPQPEVYG
CCCCCCCCCCHHHCC		22.6930108239
193PhosphorylationLSPQPEVYGHFLGVR
CCCCHHHCCEEECCC		11.8321712546
200 (in isoform 2)Phosphorylation-29.5224719451
203 (in isoform 2)Phosphorylation-6.1524719451
306 (in isoform 2)Phosphorylation-39.0427251275
322 (in isoform 2)Phosphorylation-11.2724719451
342 (in isoform 2)Phosphorylation-44.6324719451
390PhosphorylationWAGCPRRYKPFNARY
ECCCCCCCCCCCCCE		25.05-
483PhosphorylationIPGCTKRYTDPSSLR
CCCCCCCCCCHHHHH		19.6329496907
484PhosphorylationPGCTKRYTDPSSLRK
CCCCCCCCCHHHHHH		45.53-
487PhosphorylationTKRYTDPSSLRKHVK
CCCCCCHHHHHHHHH		44.8322798277
488PhosphorylationKRYTDPSSLRKHVKA
CCCCCHHHHHHHHHH		37.2724719451
531PhosphorylationVQSLQPATSPRDAAA
ECCCCCCCCHHHHHH		46.0423663014
532PhosphorylationQSLQPATSPRDAAAE
CCCCCCCCHHHHHHC		21.7523663014
541PhosphorylationRDAAAEGTVGRSPGP
HHHHHCCCCCCCCCC		15.9928857561
545PhosphorylationAEGTVGRSPGPGPDL
HCCCCCCCCCCCCCC		28.4228387310
615PhosphorylationGAERFAPSAPSPHHI
CCCCCCCCCCCCCCC		49.7528842319
618PhosphorylationRFAPSAPSPHHISPR
CCCCCCCCCCCCCCC		36.2623403867
623PhosphorylationAPSPHHISPRRVPAP
CCCCCCCCCCCCCCC		14.1625159151
641PhosphorylationLQRTQPPYTQQPSGS
HHHCCCCCCCCCCCC		24.7024702127
642PhosphorylationQRTQPPYTQQPSGSH
HHCCCCCCCCCCCCC		26.8824702127
646PhosphorylationPPYTQQPSGSHLKSY
CCCCCCCCCCCCCCC		48.9024702127
648PhosphorylationYTQQPSGSHLKSYQP
CCCCCCCCCCCCCCC		29.9524702127
657PhosphorylationLKSYQPETNSSFQPN
CCCCCCCCCCCCCCC		47.27-
687 (in isoform 2)Phosphorylation-46.6427251275
700 (in isoform 2)Phosphorylation-31.0124719451
778 (in isoform 2)Phosphorylation-24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseITCHQ96J02
PMID:26147758
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLIS3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLIS3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ITCH_HUMANITCHphysical
26147758
ANM5_HUMANPRMT5physical
26147758
SUFU_HUMANSUFUphysical
26147758
DNJA1_HUMANDNAJA1physical
26147758
DNJA1_MOUSEDnaja1physical
26147758
HIPK3_MOUSEHipk3physical
26147758
ISL1_MOUSEIsl1physical
26147758
ITCH_MOUSEItchphysical
26147758
KDM4C_MOUSEKdm4cphysical
26147758
NEDD4_MOUSENedd4physical
26147758
SMUF1_MOUSESmurf1physical
26147758
SMUF2_MOUSESmurf2physical
26147758
SPOP_MOUSESpopphysical
26147758
WWP2_MOUSEWwp2physical
26147758
ZMYM2_MOUSEZmym2physical
26147758
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
610199Diabetes mellitus, neonatal, with congenital hypothyroidism (NDH)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLIS3_HUMAN

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Related Literatures of Post-Translational Modification

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