dbPTM

ISL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ISL1_MOUSE
UniProt AC	P61372
Protein Name	Insulin gene enhancer protein ISL-1
Gene Name	Isl1
Organism	Mus musculus (Mouse).
Sequence Length	349
Subcellular Localization	Isoform 1: Nucleus . Isoform 2: Nucleus .
Protein Description	DNA-binding transcriptional activator. [PubMed: 14664703]
Protein Sequence	MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
148	Phosphorylation	LGAGDPLSPLHPARP CCCCCCCCCCCCCCC	30.70	28066266
218	Phosphorylation	KEQLVEMTGLSPRVI HHHHHHHHCCCHHHH	22.82	28066266
221	Phosphorylation	LVEMTGLSPRVIRVW HHHHHCCCHHHHHHH	16.41	28066266
240	Phosphorylation	RCKDKKRSIMMKQLQ CCCHHHHHHHHHHHH	24.58	18779572
269	Phosphorylation	GTPMVAASPERHDGG CCCEEECCCCCCCCC	19.98	28066266
326	Phosphorylation	PGSNSTGSEVASMSS CCCCCCHHHHHHHHH	29.05	-
330	Phosphorylation	STGSEVASMSSQLPD CCHHHHHHHHHCCCC	25.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ISL1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ISL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ISL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
LDB2_MOUSE	Ldb2	physical	20211142
SSBP2_MOUSE	Ssbp2	physical	20211142

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ISL1_MOUSE

Related Literatures of Post-Translational Modification