LDB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDB2_MOUSE
• UniProt AC: O55203
• Protein Name: LIM domain-binding protein 2
• Gene Name: Ldb2
• Organism: Mus musculus (Mouse).
• Sequence Length: 373
• Subcellular Localization: Nucleus . Colocalizes with SLK at leading edges (PubMed:19675209).
• Protein Description: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors..
• Protein Sequence: MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCAMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNTTNSAGSKKKTPAASLSLATQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENAPPQASQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSTPHDPF ------CCCCCCCCC	42.81	26643407
3	Phosphorylation	-----MSSTPHDPFY -----CCCCCCCCCC	44.66	26643407
4	Phosphorylation	----MSSTPHDPFYS ----CCCCCCCCCCC	19.82	26643407
37	Acetylation	YRIYEMNKRLQSRTE HHHHHHHHHHHHCCC	53.85	30986487
238	Acetylation	LKTCLFQKWQRMVAP HHHHHHHHHHHHCCC	37.65	23806337
238	Ubiquitination	LKTCLFQKWQRMVAP HHHHHHHHHHHHCCC	37.65	-
263	Phosphorylation	KRRKRKNSTSSTSNS CCCCCCCCCCCCCCC	32.47	23375375
264	Phosphorylation	RRKRKNSTSSTSNSS CCCCCCCCCCCCCCC	35.77	23375375
265	Phosphorylation	RKRKNSTSSTSNSSA CCCCCCCCCCCCCCC	31.29	29899451
266	Phosphorylation	KRKNSTSSTSNSSAG CCCCCCCCCCCCCCC	35.62	22345495
267	Phosphorylation	RKNSTSSTSNSSAGN CCCCCCCCCCCCCCC	31.52	22345495
270	Phosphorylation	STSSTSNSSAGNTTN CCCCCCCCCCCCCCC	22.72	29899451
271	Phosphorylation	TSSTSNSSAGNTTNS CCCCCCCCCCCCCCC	44.43	29899451
276	Phosphorylation	NSSAGNTTNSAGSKK CCCCCCCCCCCCCCC	31.04	22871156
278	Phosphorylation	SAGNTTNSAGSKKKT CCCCCCCCCCCCCCC	31.73	22345495
281	Phosphorylation	NTTNSAGSKKKTPAA CCCCCCCCCCCCCCH	40.81	22345495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Rlim	Q9WTV7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LHX1_MOUSE	Lhx1	physical	20211142
LHX2_MOUSE	Lhx2	physical	20211142
LHX4_MOUSE	Lhx4	physical	20211142
LHX5_MOUSE	Lhx5	physical	20211142
LHX9_MOUSE	Lhx9	physical	20211142
RBTN2_MOUSE	Lmo2	physical	20211142
LMO4_MOUSE	Lmo4	physical	20211142
LMX1B_MOUSE	Lmx1b	physical	20211142
SSBP2_MOUSE	Ssbp2	physical	20211142
PYGO1_MOUSE	Pygo1	physical	20211142
ISL2_MOUSE	Isl2	physical	20211142
LMO3_MOUSE	Lmo3	physical	20211142
RBTN1_MOUSE	Lmo1	physical	20211142
LMX1A_MOUSE	Lmx1a	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.