SC5A7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC5A7_HUMAN
• UniProt AC: Q9GZV3
• Protein Name: High affinity choline transporter 1
• Gene Name: SLC5A7
• Organism: Homo sapiens (Human).
• Sequence Length: 580
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell membrane . Cell junction, synapse . Localized at the neuromuscular junction.
• Protein Description: Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent..
• Protein Sequence: MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
301	N-linked_Glycosylation	IGASTDWNQTAYGLP HCCCCCCCCCCCCCC	31.94	UniProtKB CARBOHYD
384	Phosphorylation	IVWVMRITVFVFGAS EEEEEEEEEEHHCHH	9.49	20363803
399	Phosphorylation	ATAMALLTKTVYGLW HHHHHHHHHHHHHHH	26.06	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC5A7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC5A7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC5A7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAWR_HUMAN	PAWR	physical	15090548
NEDD4_HUMAN	NEDD4	physical	22361880

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 158580: Neuronopathy, distal hereditary motor, 7A (HMN7A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00122: Choline