SCNNG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNNG_MOUSE
• UniProt AC: Q9WU39
• Protein Name: Amiloride-sensitive sodium channel subunit gamma
• Gene Name: Scnn1g
• Organism: Mus musculus (Mouse).
• Sequence Length: 655
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Apical membrane of epithelial cells.
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..
• Protein Sequence: MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCLNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLVHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKDWWARRRTPPSTETPSSQQGQDNPALDTDDDLPTFTSAMRLPPAPEAPVPGTPPPRYNTLRLDSAFSSQLTDTQLTNEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	VRGPQAPTIKDLMHW CCCCCCCCHHHHCHH	43.61	25619855
33	S-palmitoylation	KDLMHWYCLNTNTHG HHHCHHHHCCCCCCC	1.67	24692558
41	S-palmitoylation	LNTNTHGCRRIVVSR CCCCCCCCEEEEEEH	1.73	24692558
47	Phosphorylation	GCRRIVVSRGRLRRL CCEEEEEEHHHHHHH	20.37	24719451
181	Phosphorylation	GKARDFFTGRKRKIS CCCCCCCCCCCEEEC	35.75	24719451
215	N-linked_Glycosylation	VGFQLCSNDTSDCAT EEEEEECCCCCCCHH	56.43	-
277	N-linked_Glycosylation	GMSCDARNFTLFHHP CCCCCCCCEEEEECC	35.66	-
503	N-linked_Glycosylation	QQINKKLNKTDLAKL HHHHHHCCHHHHHHH	54.80	-
505	Phosphorylation	INKKLNKTDLAKLLI HHHHCCHHHHHHHHH	34.86	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Nedd4l	Q8CFI0	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNNG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNNG_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_MOUSE	Nedd4	physical	15123669

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.