UB2J2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2J2_HUMAN
• UniProt AC: Q8N2K1
• Protein Name: Ubiquitin-conjugating enzyme E2 J2
• Gene Name: UBE2J2
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type IV membrane protein .
• Protein Description: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD)..
• Protein Sequence: MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHHGLLGGALANLFVIVGFAAFAYTVKYVLRSIAQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSTSSKRA ------CCCCCCCCC	42.18	17929957
11	Phosphorylation	TSSKRAPTTATQRLK CCCCCCCCCHHHHHH	28.25	23090842
12	Phosphorylation	SSKRAPTTATQRLKQ CCCCCCCCHHHHHHH	27.01	23090842
14	Phosphorylation	KRAPTTATQRLKQDY CCCCCCHHHHHHHHH	16.48	23090842
18	Ubiquitination	TTATQRLKQDYLRIK CCHHHHHHHHHHHHC	43.22	-
25	Ubiquitination	KQDYLRIKKDPVPYI HHHHHHHCCCCCCEE	44.69	-
26	Ubiquitination	QDYLRIKKDPVPYIC HHHHHHCCCCCCEEE	65.96	-
29 (in isoform 2)	Ubiquitination	-	8.90	21890473
31	Phosphorylation	IKKDPVPYICAEPLP HCCCCCCEEECCCCC	14.63	-
46	Phosphorylation	SNILEWHYVVRGPEM CCCCEEEEEEECCCC	11.17	-
52 (in isoform 3)	Phosphorylation	-	59.52	-
55 (in isoform 3)	Phosphorylation	-	24.70	-
56 (in isoform 3)	Phosphorylation	-	20.31	-
59 (in isoform 3)	Phosphorylation	-	14.11	-
64 (in isoform 1)	Ubiquitination	-	25.71	21890473
64	Ubiquitination	EGGYYHGKLIFPREF CCCEECCEEECCCCC	25.71	21906983
80	Ubiquitination	FKPPSIYMITPNGRF CCCCEEEEECCCCCE	2.34	21890473
104 (in isoform 2)	Ubiquitination	-	31.43	21890473
117 (in isoform 2)	Ubiquitination	-	22.60	21890473
135	Phosphorylation	TLGSIETSDFTKRQL CCCCCCCCCHHHHHH	20.24	-
139	Ubiquitination	IETSDFTKRQLAVQS CCCCCHHHHHHHHHH	37.83	21906983
139 (in isoform 1)	Ubiquitination	-	37.83	21890473
152	Ubiquitination	QSLAFNLKDKVFCEL HHHHHHCCCHHHHHH	57.52	21906983
152 (in isoform 1)	Ubiquitination	-	57.52	21890473
154	Ubiquitination	LAFNLKDKVFCELFP HHHHCCCHHHHHHHH	35.31	-
168	Ubiquitination	PEVVEEIKQKQKAQD HHHHHHHHHHHHHHH	55.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UB2J2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2J2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2J2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XIAP_HUMAN	XIAP	physical	19549727
MGRN1_HUMAN	MGRN1	physical	19549727
RNF10_HUMAN	RNF10	physical	19549727
TRI25_HUMAN	TRIM25	physical	19549727
UBC_HUMAN	UBC	physical	22496338
UB2J2_HUMAN	UBE2J2	physical	20061386
EGFR_HUMAN	EGFR	physical	29069742

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.