ANRA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANRA2_HUMAN
• UniProt AC: Q9H9E1
• Protein Name: Ankyrin repeat family A protein 2
• Gene Name: ANKRA2
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein .
• Protein Description: May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. [PubMed: 25752541 May also regulate LRP2/megalin (By similarity]
• Protein Sequence: MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Phosphorylation	KAECNIHTSPSPGIQ EEECCCCCCCCCCCE	38.24	30266825
104	Phosphorylation	AECNIHTSPSPGIQV EECCCCCCCCCCCEE	14.82	30266825
106	Phosphorylation	CNIHTSPSPGIQVRH CCCCCCCCCCCEEEE	35.21	30266825
115	Phosphorylation	GIQVRHVYTPSTTKH CCEEEEEECCCCCCC	13.55	22210691
116	Phosphorylation	IQVRHVYTPSTTKHF CEEEEEECCCCCCCC	15.07	25159151
118	Phosphorylation	VRHVYTPSTTKHFSP EEEEECCCCCCCCCC	40.69	23312004
120	Phosphorylation	HVYTPSTTKHFSPIK EEECCCCCCCCCCCC	27.19	22210691
121	Ubiquitination	VYTPSTTKHFSPIKQ EECCCCCCCCCCCCC	42.62	-
124	Phosphorylation	PSTTKHFSPIKQSTT CCCCCCCCCCCCCCC	25.99	23401153
127	Ubiquitination	TKHFSPIKQSTTLTN CCCCCCCCCCCCCCC	41.39	-
142	Phosphorylation	KHRGNEVSTTPLLAN CCCCCCCCCHHHHCC	22.01	26074081
143	Phosphorylation	HRGNEVSTTPLLANS CCCCCCCCHHHHCCC	37.29	26074081
144	Phosphorylation	RGNEVSTTPLLANSL CCCCCCCHHHHCCCC	12.39	26074081
150	Phosphorylation	TTPLLANSLSVHQLA CHHHHCCCCCHHHHH	19.20	28122231
152	Phosphorylation	PLLANSLSVHQLAAQ HHHCCCCCHHHHHHH	19.85	28122231
280	Phosphorylation	DPTIETDSGYNSMDL CCCCCCCCCCCHHHH	51.07	46163713

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANRA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANRA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANRA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP2_HUMAN	LRP2	physical	11095640
HDAC4_HUMAN	HDAC4	physical	22649097
RFX5_HUMAN	RFX5	physical	22649097
LRP2_HUMAN	LRP2	physical	22649097
HDAC3_HUMAN	HDAC3	physical	22649097
HDAC5_HUMAN	HDAC5	physical	22649097
ABL1_HUMAN	ABL1	physical	22649097
TPOR_HUMAN	MPL	physical	22649097
PDE3B_HUMAN	PDE3B	physical	22649097
A4_HUMAN	APP	physical	21832049
CCDC8_HUMAN	CCDC8	physical	25752541
RFX7_HUMAN	RFX7	physical	25752541
HUWE1_HUMAN	HUWE1	physical	25752541
RFX5_HUMAN	RFX5	physical	25752541
ZN462_HUMAN	ZNF462	physical	25752541
CUL7_HUMAN	CUL7	physical	25752541
LMNB2_HUMAN	LMNB2	physical	25752541
TIF1B_HUMAN	TRIM28	physical	25752541
SOGA1_HUMAN	SOGA1	physical	25752541
CCAR2_HUMAN	CCAR2	physical	25752541
OBSL1_HUMAN	OBSL1	physical	25752541
LMNA_HUMAN	LMNA	physical	25752541
CDK4_HUMAN	CDK4	physical	25752541
RFXAP_HUMAN	RFXAP	physical	25752541
PRDX2_HUMAN	PRDX2	physical	25752541
HDAC5_HUMAN	HDAC5	physical	25752541
TF3C5_HUMAN	GTF3C5	physical	25752541
FA83B_HUMAN	FAM83B	physical	25752541
PHB2_HUMAN	PHB2	physical	25752541

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.