dbPTM

HSP83_ANOGA - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSP83_ANOGA
UniProt AC	Q7PT10
Protein Name	Heat shock protein 83
Gene Name	Hsp83 {ECO:0000250\|UniProtKB:P02828}
Organism	Anopheles gambiae (African malaria mosquito).
Sequence Length	720
Subcellular Localization	Cytoplasm .
Protein Description	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity)..
Protein Sequence	MPEPQEGETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLESGKELFIKIIPNKEAGTLTLIDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVVVTSKNNDDEQYVWESSAGGSFTVRPDSGEPLGRGTKIVLHIKEDQLEYLEESKIKQIVNKHSQFIGYPIKLLVEKEREKEVSDDEAEEEKKEEKEEKKDDEPKLEDAEDDEDKKDKKKKTVKVKYTEDEELNKTKPIWTRNADDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLDFRALLFVPRRMPFDLFENKKKKNNIKLYVRRVFIMDNCEELIPDYLNFIKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEELAEDKETYKKFYDQFSKNLKLGVHEDSQNRQKLADLLRFNTSASGDEYCSLNDYVGRMKENQTQIYFITGESIDQVKNSAFVERVKKRGFEVIYMTEPIDEYVIQQLKEYKGKQLVSVTKEGLELPEDEAEKKKREEDKAKFENLCKVMKSVLESKVEKVMVSNRLVDSPCCIVTSQYGWSANMERIMKAQALRDSSAMGYMAGKKHLEINPDHAIIETLRQRAEADKNDKAVKDLVILLFETALLSSGFSLDEPGTHASRIYRMIKLGLGIDEDEPMTTEESSSGAAAAAPASGDAPPLVDDSEDLSHMEEVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of HSP83_ANOGA !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSP83_ANOGA !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSP83_ANOGA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSP83_ANOGA !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HSP83_ANOGA !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSP83_ANOGA

Related Literatures of Post-Translational Modification